Effects of Benzalkonium Chloride on the Blood–Aqueous and Blood–Retinal Barriers of Pseudophakic Eyes

Abstract

Our results suggest that a short-term exposure to BAK can cause disruption of the BAB, without altering the BRB in pseudophakic eyes.

Cystoid macular edema related to cataract surgery and topical prostaglandin analogs: Mechanism, diagnosis, and management

“…Similarly, a prospective, randomized, investigatormasked study (N ¼ 44) showed that artificial tears containing BAK increased aqueous humor flare compared with preservative-free artificial tears. 1 Although there were no cases of CME in this small study, it was concluded that BAK may cause blood-aqueous barrier disruption but does not lead to blood-retinal barrier disruption. Sufficiently powered randomized investigations are necessary to clarify if BAKpreserved formulations of topical PGA and PGA-timolol fixed-dose combinations increase the risk of CME development compared with the corresponding preservative-free formulations in pseudophakic eyes.…”

Effects of preservatives used in ocular medications on the eye: a comparative review

“…However, the authors did not note any significant increase in macular thickness in either group. The authors concluded that short-term BAK exposure causes disruption of blood-aqueous barriers but not blood-retinal barriers in pseudophakic eyes [41].…”

IOP-lowering therapy and ocular surface in glaucoma. Part 2. The effect of preservatives on ocular surface

“…барьера у артифакичных паци-ентов, обусловленного, по мнению авторов, присутствием консерванта в водянистой влаге. Вызванное тем самым субклиническое воспаление [35] якобы повышает риск развития кистозного макулярного отека.…”