Effects of berbamine on cardiac functions in Isolated working guinea pig hearts

Berbamine Protects the Heart From Ischemia/Reperfusion Injury by Maintaining Cytosolic Ca²⁺ Homeostasis and Preventing Calpain Activation

“…Moreover, the concentrations for berbamine-afforded cardioprotection are much lower than those causing a negative inotropic effect in the isolated hearts, as demonstrated recently. 9, 29 Further, the present data show that the improvement of post-ischemic myocardial performance by berbamine is related to its direct action on the cardiomyocytes. These data suggest a potential therapeutic role of berbamine in cardioprotection within an optimal concentration range.…”