Effects of berberine on diabetes induced by alloxan and a high-fat/high-cholesterol diet in rats

Tang, Ling‐Zhi; Wei, Wei; Chen, Liming; Liu, Sheng

doi:10.1016/j.jep.2006.04.019

Cited by 236 publications

(142 citation statements)

References 28 publications

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“…The pancreatic islets from both control groups displayed normal histological features: the islets are oval ( Figure 2A) and spread throughout the exocrine structures, the acinis. This finding is in agreement with the description of Tang et al (2006). The Gomori stain ( Figures 2B and 2C) demonstrates that β cells are found mainly in the central region of the islets, while some are in the peripheral region.…”

Section: Histopathological Resultssupporting

confidence: 92%

“…In the untreated diabetic rats (Figure 2D), the islets have shrunk: they have a reduced diameter and irregular shape, with a small number of cells and vacuolization of the cytoplasm. The same pattern was described by Tang et al (2006). The Gomori stain ( Figure 2E) did not display green stain, indicating the absence of insulin granules, in accordance with the description of Diani et al (2004).…”

Section: Histopathological Resultssupporting

confidence: 86%

“…DM2 is the most common form of the disease, accounting for 85 to 90% of all recorded cases (Tiwari, Rao, 2002). Besides hyperglycemia, hyperlipidemia is involved in the development of the micro and macro vascular complications of diabetes, which are the major causes of morbidity and death (Tang et al, 2006). Despite the great efforts made to better understand and manage this disease, serious problems such as retinopathy, nephropathy and lower extremity amputation continue to affect patients, while diabetes-related mortality is rising unabated (Tiwari, Rao, 2002).…”

Section: Introductionmentioning

confidence: 99%

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Anti-diabetic effects of Campomanesia xanthocarpa (Berg) leaf decoction

Vinagre

Rönnau

Pereira

et al. 2010

Braz. J. Pharm. Sci.

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The objective of this research was to identify the effects of 3-week treatment of normal and streptozotocininduced diabetic rats using a leaf decoction of Campomanesia xanthocarpa Berg. (20 g/L) on physiological, biochemical and histological parameters. Streptozotocin (STZ, 70 mg/kg in citrate buffer, pH 4.5) was administered IP to induce experimental diabetes one week prior to the treatment. STZ caused typical diabetic symptoms: polydypsia, polyuria, polyphagia, hyperglycemia, hypertriglyceridemia and histopathological modifications in the pancreas, liver and kidney. The treatment of diabetic rats using the decoction decreased blood glucose levels, inhibited hepatic glycogen loss, and prevented potential histopathological alterations in the pancreas and kidneys. No differences were found between the control rats treated with the decoction and the control rats maintained on water only. In conclusion, these results suggest that C. xanthocarpa leaf decoction (20g/L) might be useful for diabetes mellitus management, but further pharmacological and toxicological studies are needed. O objetivo deste trabalho foi identificar os efeitos do tratamento com o decocto das folhas de Campomanesia xanthocarpa Berg. (20 g/L), durante 3 semanas, sobre parâmetros fisiológicos, bioquímicos e histológicos de ratos normais e diabéticos induzidos por estreptozotocina. O diabete melito foi induzido uma semana antes de iniciar o tratamento experimental, pela administração IP de estreptozotocina (STZ, 70 mg/ kg em tampão citrato, pH 4.5). Os ratos tratados com STZ apresentaram sintomas típicos de diabete: polifagia, polidipsia, hiperglicemia, hipertrigliceridemia e alterações histopatológicas no pâncreas, fígado e rim. O tratamento dos ratos diabéticos com o decocto diminuiu os níveis de glicose sanguínea, inibiu a degradação do glicogênio hepático e preveniu possíveis alterações histopatológicas no pâncreas e no rim. Nos ratos controles tratados com o decocto não foram verificadas diferenças significativas em relação aos controles tratados com água. Em conclusão, os resultados sugerem que o tratamento com o decocto das folhas de C. xanthocarpa leaf decoction (20 g/L) possa ser útil para o manejo do diabete melito, porém estudos farmacológicos e toxicológicos ainda são necessários.Unitermos: Campomanesia xanthocarpa/farmacognosia. Diabete Melito/estudo experimental. Planta hipoglicemiante. Carboidratos/metabolismo. Lipídeos/metabolismo.

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Section: Histopathological Resultssupporting

confidence: 92%

Section: Histopathological Resultssupporting

confidence: 86%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Anti-diabetic effects of Campomanesia xanthocarpa (Berg) leaf decoction

Vinagre

Rönnau

Pereira

et al. 2010

Braz. J. Pharm. Sci.

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“…Reductions of plasma TAG by BBR were also observed in other studies in rats with diabetes and nephritis [42,43,47]. Results from several in vitro studies have demonstrated that BBR decreases TAG levels through regulating fatty acid metabolism toward the downregulation of adipogenesis [51][52][53].…”

Section: Discussionsupporting

confidence: 63%

“…It could also be due to the differences in cholesterol metabolism between humans and animal species [44][45][46]. In addition, it should be noted that the effect of BBR on blood cholesterol in rats was previously examined only in disease models such as diabetes or nephritis [42,43,47]. Response of plasma lipids to BBR treatment in these disease models may be different from that in healthy animal models.…”

Section: Discussionmentioning

confidence: 99%

Co-administration of berberine and plant stanols synergistically reduces plasma cholesterol in rats

Xiao-ming¹,

Chen

Zidichouski³

et al. 2008

Atherosclerosis

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The objective of the present study was to determine the beneficial effects and the safety of oral administration of the combination of berberine (BBR) and plant stanols (PS) on plasma lipid profiles in male Sprague-Dawley rats. Four groups of animals were fed a cornstarch-casein-sucrose-based high-cholesterol (2%, w:w) and high-fat (27.5%) diet. Three treatment groups were supplemented with either BBR (100 mg kg −1 body weight d −1 ), PS (1% in diet, w:w), or the combination of both (BBRPS). After 6 wk, animals were sacrificed and followed immediately with the collection of blood and organ samples. Lipid analysis revealed that PS lowered plasma total cholesterol (T-C) by 18% (p = 0.067) and non-HDL-cholesterol (non-HDL-C) by 29% (p = 0.013) as compared with the control, while BBR had no effect on both T-C and non-HDL-C. The combination treatment of BBRPS reduced plasma T-C by 41% (p = 0.0002) and non-HDL-C by 59% (p < 0.0001) compared to the control group. BBR reduced plasma TG levels by 31% at a marginal significance relative to the control (p = 0.054), whereas PS had no effect. BBRPS showed an additive effect of BBR and PS on plasma TAG. PS and BBRPS both decreased liver cholesterol (p = 0.0027 and 0.0002, respectively). BBR and PS, either alone or in combination, did not show any toxic effects as assessed by plasma concentration of hepatic biochemical parameters. These results demonstrate that BBR and PS, when combined, synergistically lower plasma cholesterol levels and significantly reduce liver cholesterol, without the observation of any toxic effects. Crown

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Oxidative stress and inflammation, two features associated with a high percentage body fat, and that may lead to diabetes mellitus and metabolic syndrome

et al. 2018

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Obesity is an important feature of the metabolic syndrome and is associated with an increased risk of type 2 diabetes mellitus, cardiovascular disease, and some cancers. The aim of this study was to determine the relationship between body fat percentage and an imbalance of the prooxidant/antioxidant balance (PAB), serum superoxide dismutase (SOD1) and inflammation (serum hs‐CRP) and increase risk of metabolic syndrome and diabetes mellitus. In this study, 9154 individuals were recruited as part of the Mashhad Stroke and Heart Association Disorder (MASHAD) study. Subjects were categorized into two groups according to body fat percentage as defined >25% in male and > 30% in female, according to gender. Biochemical factors, including serum PAB, SOD1, and hs‐CRP were measured in all subjects. SPSS version 18 was used for statistical analyses for all. GraphPad Prism 6 for figures was used. Of total number of subjects (9154), 6748 (73.7%) were found to have a high body fat (BF) percentage. Serum hs‐CRP and PAB were significantly higher in individuals with a high BF percentage (P < 0.05) but SOD1 was not significantly different between the two groups (P > 0.05). BF percentage, serum PAB and serum hs‐CRP were significantly higher in individuals with metabolic syndrome and diabetes versus those without metabolic syndrome and diabetes mellitus (P < 0.05), however serum SOD1 was significantly lower in individuals with metabolic syndrome (P < 0.005). Oxidative stress and inflammation are two factors that may link the presence of high BF percentage with the development of metabolic syndrome, diabetes, and cardiovascular disease. © 2018 BioFactors, 45(1):35–42, 2019

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Effects of berberine on diabetes induced by alloxan and a high-fat/high-cholesterol diet in rats

Cited by 236 publications

References 28 publications

Anti-diabetic effects of Campomanesia xanthocarpa (Berg) leaf decoction

Anti-diabetic effects of Campomanesia xanthocarpa (Berg) leaf decoction

Co-administration of berberine and plant stanols synergistically reduces plasma cholesterol in rats

Oxidative stress and inflammation, two features associated with a high percentage body fat, and that may lead to diabetes mellitus and metabolic syndrome

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