1993
DOI: 10.1007/bf00877715
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Effects of beta-blockers and Ca2+ -antagonists on the response of the isolated working rat heart to adrenergic stimulants after cardioplegic arrest

Abstract: During coronary artery bypass graft (CABG) surgery, patients pretreated with the combination of beta-blocking drugs and Ca2+ antagonists for control of myocardial ischemia often respond inadequately to adrenergic stimulants administered after cardioplegic arrest. In this study, the effects of the combination of a beta-blocker (propranolol) and a Ca2+ antagonist (nifedipine) on the spontaneous recovery, as well as the adrenergic response of the isolated, perfused, working rat heart after a period of cardioplegi… Show more

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