Effects of Beta-zone Peripapillary Atrophy and Focal Lamina Cribrosa Defects on Peripapillary Vessel Parameters in Young Myopic Eyes

Choe, Sooyeon; Kim, Young Kook; Lim, Hyung Bin; Park, Ki Ho; Jeoung, Jin Wook

doi:10.1097/ijg.0000000000001890

Cited by 4 publications

(3 citation statements)

References 37 publications

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“…The findings of the present study possibly explain the phenomenon of topographic distribution of localized LC defect and its association with glaucoma. Previous studies have shown that large LC pores and LC defects are located mostly on the temporal rather than the nasal side 27 , 28 . We can postulate that axial-elongation-associated stretching of the temporal LC generates tensile force that results in localized LC defect on the temporal side.…”

Section: Discussionmentioning

confidence: 98%

Nasal and temporal curvatures of lamina CRIBROSA in myopic eyes

Choe

Joo

Kim

et al. 2022

Sci Rep

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Little is known about the myopic characteristics of lamina cribrosa (LC) curvature. As such, we investigated nasal and temporal LC curvatures in myopia. In this retrospective, cross-sectional study, 144 myopic eyes (refraction < − 2D) and 88 non-myopic eyes (refraction > − 0.5D) underwent swept-source optical coherence tomography scanning of the LC. The anterior border of LC curvature was delineated with 17 points and interpolated with the “cardinal spline” curve-fitting method. The average curvature indices of the temporal and nasal sides were presented as the temporal and nasal curvatures. Myopic eyes had a mean refraction of − 6.7 ± 2.8D, while for non-myopic eyes, the value was 0.3 ± 1.0D. Nasal LC curvature was visible in 54 myopia (37.5%) and 42 non-myopia (47.7%) cases (P = 0.126), and temporal LC curvature was visible in 142 myopia (98.6%) and 68 non-myopia (77.3%) cases (P = 0.001). The nasal LC curvature was significantly larger in myopia than in non-myopia (P < 0.001). Contrastingly, the temporal LC curvature was significantly smaller in myopia than in non-myopia (P < 0.001). Axial length was associated with larger nasal LC curvature, smaller temporal LC curvature, and larger nasal–temporal LC curvature difference (all P’s < 0.05). In myopic relative to non-myopic eyes, LC curvature was decreased temporally and increased nasally.

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Section: Discussionmentioning

confidence: 98%

Nasal and temporal curvatures of lamina CRIBROSA in myopic eyes

Choe

Joo

Kim

et al. 2022

Sci Rep

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“…40,43 Also, a considerable number of myopic eyes (average AXL 25.0 mm) were included in this study, thus limiting the applicability of those 2 parameters. Given that both MvD and focal LC defects can be observed in eyes the myopia, 44,45 further studies on the development of vascular and structural changes of the deep ONH tissue in myopic glaucomatous eyes are warranted. Fourth, eyes with diabetes, hypertension, and various glaucoma medications were included in this study, and this may be the potentially confounding factor related to the vascular parameters.…”

Section: Discussionmentioning

confidence: 99%

Optic Disc Microvasculature Dropout in Preperimetric Glaucoma

Suh,

Weinreb,

Zangwill

2024

Journal of Glaucoma

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Purpose: To investigate factors associated with optic disc microvasculature dropout (MvD-D) in pre-perimetric primary open-angle glaucoma (PPG) patients. Methods: 139 eyes of PPG patients were categorized according to the presence of MvD-D with optical coherence tomography angiography (OCTA). Factors including visual field (VF) mean deviation (MD), retinal nerve fiber layer (RNFL) thickness, focal lamina cribrosa (LC) defect, optic disc hemorrhage (DH), and parapapillary deep-layer microvasculature dropout (MvD-P) were compared between eyes with and without MvD-D. Results: MvD-D was observed in 69 PPG eyes (49.6%). Compared with eyes without MvD-D, the ones with MvD-D had a significantly thinner RNFL in all areas except the nasal sector, worse VF MD, and a focal LC defect and MvD-P (P<0.05): male gender also was more highly prevalent. A considerable number of eyes with MvD-D lacked focal LC defect (62.3% (43/69)) or MvD-P (71.0% (49/69)), while a few eyes without MvD-D had focal LC defect (10.0% (7/70)) or MvD-P (2.9% (2/70)). In a multivariable logistic regression analysis, male gender (odds ratio [OR], 3.96; P<0.001), worse VF MD (OR, 1.44; P=0.019), thinner global RNFL (OR, 1.13; P<0.001), higher prevalence of focal LC defect (OR, 3.71; P=0.014) and MvD-P (OR, 7.85; P<0.001) were significantly associated with MvD-D. Conclusions: MvD-D was related to worse disease severity in PPG patients, and often was not accompanied by focal LC defect or MvD-P. This suggests that impaired optic disc circulation can be an early sign of glaucoma without noticeable changes in functional or structural features (i.e., VF, focal LC defect, MvD-P).

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“…However, this conclusion might not be applicable to highly myopic eyes, as researchers excluded eyes with myopic tilted disks and gamma zones. Choe et al initially demonstrated a significant reduction in PVD or perfusion density (PD) using OCTA with the development of focal LC defects in young myopic patients, suggesting an increasing risk of glaucoma in the future ( 43 ).…”

Section: Papillary/peripapillary Tissue Defectmentioning

confidence: 99%

Multimodal imaging of optic nerve head abnormalities in high myopia

Hu,

Wu,

et al. 2024

Front. Neurol.

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Highly myopic optic nerve head (ONH) abnormalities encompass a series of complications resulting from the stretching of papillary and peripapillary structures during significant axial elongation. The morphological changes in the ONH typically initiate with disk tilting or rotation, progressing to PHOMS and PPA. Tissue defects in each layer manifest as focal lamina cribrosa defects (FLDs), peripapillary intrachoroidal cavitations (PICCs), and acquired pits of the optic nerve (APON). Anterior vitreous/vascular traction and posterior scleral protrusion may lead to prelaminar schisis as well as paravascular cysts and holes, which can potentially develop into retinoschisis. Traditional color fundus photography (CFP) is often insufficient for visualizing most of these lesions, yet their description and quantification benefit significantly from the advancements in optical coherence tomography (OCT) and OCT angiography (OCTA), complemented by fundus autofluorescence (FAF), indocyanine green angiography (ICGA), and three-dimensional imaging. The effective diagnosis and classification of ONH abnormalities heavily rely on a comprehensive understanding of their multimodal imaging features, as outlined in this review. These findings provide valuable insights into optic neuropathy in high myopia, establishing a solid foundation for future endeavors in disease monitoring and treatment guidance.

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Effects of Beta-zone Peripapillary Atrophy and Focal Lamina Cribrosa Defects on Peripapillary Vessel Parameters in Young Myopic Eyes

Cited by 4 publications

References 37 publications

Nasal and temporal curvatures of lamina CRIBROSA in myopic eyes

Nasal and temporal curvatures of lamina CRIBROSA in myopic eyes

Optic Disc Microvasculature Dropout in Preperimetric Glaucoma

Multimodal imaging of optic nerve head abnormalities in high myopia

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