Effects of betaine supplementation on cardiovascular markers: A systematic review and Meta-analysis

Ashtary‐Larky, Damoon; Bagheri, Reza; Ghanavati, Matin; Asbaghi, Omid; Tinsley, Grant M.; Mombaini, Delsa; Kooti, Wesam; Kashkooli, Sara; Wong, Alexei

doi:10.1080/10408398.2021.1902938

Cited by 29 publications

(23 citation statements)

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“…In our study, we considered trials that met the following criteria: (1) placebo-controlled RCTs, (2) studies that were performed on adults (≥18 years), (3) used a nano-curcumin supplementation/consumption intervention, (4) RCTs with an intervention length of at least two weeks, (5) studies that assessed risk factors for CVD (lipid profile, glycemic control factors, inflammatory mediators, obesity measures, blood pressure (BP)) as an outcome, (6) If >1 article was published from a single dataset, the more thorough article was incorporated. RTCs containing > 1 intervention group were deemed independent datasets.…”

Section: Inclusion Criteriamentioning

confidence: 99%

“…Cardiovascular disease (CVD) is the leading cause of death worldwide, placing heavy economic and health burdens on society [1]. Risk factors for CVD such as obesity, hypertension, diabetes, metabolic syndrome, nonalcoholic fatty liver disease, and dyslipidemia lead to increased atherosclerosis [2,3], considered by many to be the most important component in CVD pathologies. Consequently, improving the risk factors for CVD disease is essential to lessen the morbidity and mortality of this condition.…”

Section: Introductionmentioning

confidence: 99%

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The Effects of Nano-Curcumin Supplementation on Risk Factors for Cardiovascular Disease: A GRADE-Assessed Systematic Review and Meta-Analysis of Clinical Trials

et al. 2021

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Background: Previous studies have indicated that curcumin supplementation may be beneficial for cardiometabolic health; however, current evidence regarding the effects of its nanorange formulations, popularly known as “nano-curcumin”, remains unclear. This systematic review and meta-analysis aimed to determine the impact of nano-curcumin supplementation on risk factors for cardiovascular disease. Methods: PubMed, Scopus, Embase, and ISI web of science were systematically searched up to May 2021 using relevant keywords. All randomized controlled trials (RCTs) investigating the effects of nano-curcumin supplementation on cardiovascular disease risk factors were included. Meta-analysis was performed using random-effects models, and subgroup analysis was performed to explore variations by dose and baseline risk profiles. Results: According to the results of this study, nano-curcumin supplementation was associated with improvements in the glycemic profile by decreasing fasting blood glucose (FBG) (WMD: −18.14 mg/dL; 95% CI: −29.31 to −6.97; p = 0.001), insulin (WMD: −1.21 mg/dL; 95% CI: −1.43 to −1.00; p < 0.001), and HOMA-IR (WMD: −0.28 mg/dL; 95% CI: −0.33 to −0.23; p < 0.001). Interestingly, nano-curcumin supplementation resulted in increases in high-density lipoprotein (HDL) (WMD: 5.77 mg/dL; 95% CI: 2.90 to 8.64; p < 0.001). In terms of other lipid profile markers (triglyceride (TG), total cholesterol (TC), and low-density lipoprotein (LDL)), subgroup analyses showed that nano-curcumin supplementation had more favorable effects on lipid profiles in individuals with dyslipidemia at baseline. Nano-curcumin supplementation also showed favorable anti-inflammatory effects by decreasing C-reactive protein (CRP) (WMD: −1.29 mg/L; 95% CI: −2.15 to −0.44; p = 0.003) and interleukin-6 (IL-6) (WMD: −2.78 mg/dL; 95% CI: −3.76 to −1.79; p< 0.001). Moreover, our results showed the hypotensive effect of nano-curcumin, evidenced by a decrease in systolic blood pressure (SBP). Conclusions: In conclusion, our meta-analysis suggests that nano-curcumin supplementation may decline cardiovascular disease risk by improving glycemic and lipid profiles, inflammation, and SBP. Future large-scale investigations with longer durations are needed to expand on our findings.

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Section: Inclusion Criteriamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Effects of Nano-Curcumin Supplementation on Risk Factors for Cardiovascular Disease: A GRADE-Assessed Systematic Review and Meta-Analysis of Clinical Trials

et al. 2021

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“…Nutritional and physical activity strategies have gained substantial interest in the prevention and treatment of non‐communicable chronic diseases 20–24 . For instance, saffron ( Crocus sativus L .)…”

Section: Introductionmentioning

confidence: 99%

“…4,7 Nutritional and physical activity strategies have gained substantial interest in the prevention and treatment of non-communicable chronic diseases. [20][21][22][23][24] For instance, saffron (Crocus sativus L.) is a plant from the Iridaceae family and a carotenoid-rich spice. The chief bioactive components of saffron are crocin, crocetin, picrocrocin, and safranal, which could contribute to its wide range of biological properties.…”

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confidence: 99%

The effects of saffron (Crocus sativus L.) in conjunction with concurrent training on body composition, glycaemic status, and inflammatory markers in obese men with type 2 diabetes mellitus: A randomized double‐blind clinical trial

Moghadam

Rashidlamir

Hosseini

et al. 2022

Brit J Clinical Pharma

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Aims Chronic inflammation is one of the major challenges in the management of obesity and type 2 diabetes mellitus (T2DM). Our primary aim was to assess the anti‐inflammatory effects of Saffron (Crocus sativus L.) supplementation and concurrent training in obese men with T2DM. Methods Sixty obese men with T2DM (age = 39 ± 5 years; body mass = 93.9 ± 6 kg) were randomly assigned to four groups; concurrent training + placebo (CT; n = 15), saffron supplementation (S; n = 15), concurrent training + saffron supplementation (CTS; n = 15), or control (CON; n = 15). The participants in the CT group performed concurrent training (resistance + aerobic) three times per week for 12 weeks and received daily one pill of placebo (maltodextrin); the participants in the S group supplemented with one pill of 100 mg of saffron daily, and the participants in the CTS group participated in both saffron and training intervention while CON group continued regular lifestyle (no training and no supplementation). Inflammatory markers, body composition (evaluated by a multi‐frequency bioelectrical impedance device; Jawon X‐Contact 356), and metabolic profile were evaluated before and after interventions. Results All three interventions significantly (P < .05) decreased TNF‐α (CT = −4.22, S = −1.91, CTS = −9.69 pg/mL), hs‐CRP (CT = −0.13, S = −0.1, CTS = −0.32 ng/mL), IL‐6 (CT = −6.84, S = −6.36, CTS = −13.55 pg/mL), IL‐1β (CT = −8.85, S = −6.46, CTS = −19.8 pg/mL), FBG (CT = −6.97, S = −2.45, CTS = −13.86 mg/dL), insulin (CT = −0.13, S = −0.03, CTS = −0.21 mU/L), HOMA‐IR (CT = −0.12, S = −0.04, CTS = −0.21), HbA1c (CT = −0.17, S = −0.11, CTS = −0.26%), and increased IL‐10 (CT = 1.09, S = 0.53, CTS = 2.27 pg/mL) concentrations. There was a positive correlation between changes in BFP with hs‐CRP, IL‐6, IL‐1β and TNF‐α, and IL‐10 concentrations across the intervention groups. Additionally, significant differences were observed between the changes for all variables in the CTS group compared to CT, S and CON groups (P < .05). Conclusion It seems that an interaction of saffron supplementation and concurrent training has more efficient effects on anti‐inflammatory status compared to saffron supplementation or concurrent training alone.

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“…Intakes of 9-15 g of betaine appear to be safe in humans (4) . Besides dietary intake, betaine can be made from choline in the human body (5) . Previous studies indicate that betaine supplementation may improve cardiovascular risk and inflammatory status (5,6) .…”

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Betaine supplementation fails to improve body composition: a systematic review and meta-analysis

et al. 2021

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Previous studies evaluating the effects of betaine supplementation on body composition offer contradictory findings. This systematic review and meta-analysis assessed the effects of betaine supplementation on body composition indices (body mass [BM], body mass index [BMI], body fat percentage [BFP], fat mass [FM], fat-free mass [FFM]), and dietary intakes. Studies examining the effects of betaine supplementation on body composition and dietary intakes published up to August 2021 were identified through PubMed, the Cochrane Library, Web of Science, Embase, SCOPUS, and Ovid databases. Betaine supplementation failed to significantly affect BM [(WMD: −0.40 kg, 95% CI: −1.46 to 0.64), p=0.447], BMI [(WMD: −0.05 kg/m2, 95% CI: −0.36 to 0.25), p=0.719], BFP [(WMD: 0.26%, 95% CI: −0.82 to 1.36), p=0.663], FM [(WMD: −0.57 kg, 95% CI: −2.14 to 0.99), p=0.473], and FFM [(WMD: 0.61 kg, 95% CI: −1.27 to 2.49), p=0.527]. Subgroup analyses based on participant’s age (<40 and >40 years), sex, BMI, trial duration (<8 and ≥8 weeks), betaine supplementation dosage (<4 and ≥4 g), and health status (healthy or unhealthy) demonstrated similar results. Other than a potential negligible increase in protein intake (WMD: 3.56 g, 95% CI: 0.24 to 6.88, p=0.035), no changes in dietary intakes were observed following betaine supplementation compared to control. The present systematic review and meta-analysis does not show any beneficial effects of betaine supplementation on body composition indices (BM, BMI, FM, and FFM).

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Effects of betaine supplementation on cardiovascular markers: A systematic review and Meta-analysis

Cited by 29 publications

References 72 publications

The Effects of Nano-Curcumin Supplementation on Risk Factors for Cardiovascular Disease: A GRADE-Assessed Systematic Review and Meta-Analysis of Clinical Trials

The Effects of Nano-Curcumin Supplementation on Risk Factors for Cardiovascular Disease: A GRADE-Assessed Systematic Review and Meta-Analysis of Clinical Trials

The effects of saffron (Crocus sativus L.) in conjunction with concurrent training on body composition, glycaemic status, and inflammatory markers in obese men with type 2 diabetes mellitus: A randomized double‐blind clinical trial

Betaine supplementation fails to improve body composition: a systematic review and meta-analysis

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