Effects of Bifidobacterial Supplementation to Pregnant Women and Infants in the Prevention of Allergy Development in Infants and on Fecal Microbiota

Enomoto, Tadao; Sowa, M; Nishimori, K.; Shimazu, Shinichiro; Yoshida, Akira; Yamada, Kazuko; Furukawa, Fukumi; Nakagawa, Takemasa; Yanagisawa, Naotake; Iwabuchi, Noriyuki; Odamaki, Toshitaka; Abe, Fumiaki; Nakayama, Jiro; Xiao, Jin

doi:10.2332/allergolint.13-oa-0683

Cited by 142 publications

(100 citation statements)

References 42 publications

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“…This bacterium produces high levels of SCFAs and promotes epithelial integrity (Fukuda et al, 2011). Bifidobacterium alleviates food allergy in mice (Kim et al, 2016) and its administration to pregnant women significantly reduced allergy in offspring, and this correlated with changes in gut microbiota composition (Enomoto et al, 2014), possibly through SCFA elevation. Oral immunotherapy with the probiotic Lactobacillus Rhamnosus, a high-SCFA producer, led to peanut unresponsiveness in 82% of allergic children (Tang et al, 2015).…”

Section: Discussionmentioning

confidence: 98%

Dietary Fiber and Bacterial SCFA Enhance Oral Tolerance and Protect against Food Allergy through Diverse Cellular Pathways

et al. 2016

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The incidence of food allergies in western countries has increased dramatically in recent decades. Tolerance to food antigens relies on mucosal CD103(+) dendritic cells (DCs), which promote differentiation of regulatory T (Treg) cells. We show that high-fiber feeding in mice improved oral tolerance and protected from food allergy. High-fiber feeding reshaped gut microbial ecology and increased the release of short-chain fatty acids (SCFAs), particularly acetate and butyrate. High-fiber feeding enhanced oral tolerance and protected against food allergy by enhancing retinal dehydrogenase activity in CD103(+) DC. This protection depended on vitamin A in the diet. This feeding regimen also boosted IgA production and enhanced T follicular helper and mucosal germinal center responses. Mice lacking GPR43 or GPR109A, receptors for SCFAs, showed exacerbated food allergy and fewer CD103(+) DCs. Dietary elements, including fiber and vitamin A, therefore regulate numerous protective pathways in the gastrointestinal tract, necessary for immune non-responsiveness to food antigens.

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Section: Discussionmentioning

confidence: 98%

Dietary Fiber and Bacterial SCFA Enhance Oral Tolerance and Protect against Food Allergy through Diverse Cellular Pathways

et al. 2016

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“…84–86 In an open trial of potential treatment for reduced gut bacterial diversity in AD, mothers were supplemented with Bifidobacterium starting at 1 month before delivery followed by Bifidobacterium supplementation to the infant until 6 months of age. 87 Compared to unsupplemented controls, the supplemented infants were found to have reduced risk of developing AD during the first 18 months of life, and pyrosequencing analyses showed differences in gut microbiota in those who developed AD. 87 …”

Section: Microbiomementioning

confidence: 94%

“…87 Compared to unsupplemented controls, the supplemented infants were found to have reduced risk of developing AD during the first 18 months of life, and pyrosequencing analyses showed differences in gut microbiota in those who developed AD. 87 …”

Section: Microbiomementioning

confidence: 94%

Systems biology of asthma and allergic diseases: A multiscale approach

Bunyavanich¹,

Schadt²

2015

Journal of Allergy and Clinical Immunology

132

128

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Systems biology is an approach to understanding living systems that focuses on modeling diverse types of high-dimensional interactions to develop a more comprehensive understanding of complex phenotypes manifested by the system. High throughput molecular, cellular, and physiologic profiling of populations is coupled with bioinformatic and computational techniques to identify new functional roles for genes, regulatory elements, and metabolites in the context of the molecular networks that define biological processes associated with system physiology. Given the complexity and heterogeneity of asthma and allergic diseases, a systems biology approach is attractive, as it has the potential to model the myriad connections and interdependencies between genetic predisposition, environmental perturbations, regulatory intermediaries, and molecular sequelae that ultimately lead to diverse disease phenotypes and treatment responses across individuals. The increasing availability of high-throughput technologies has enabled system-wide profiling of the genome, transcriptome, epigenome, microbiome, and metabolome, providing fodder for systems biology approaches to examine asthma and allergy at a more holistic level. In this article, we review the technologies and approaches for system-wide profiling as well as their more recent applications to asthma and allergy. We discuss approaches for integrating multiscale data through network analyses and provide perspective on how individually-captured health profiles will contribute to more accurate systems biology views of asthma and allergy.

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“…Это позволило увеличить кишечную популяцию бактероидов, лактоба-цилл, бифидобактерий и энтерококков, тогда как количество Clostridium coccoides уменьши-лось. Лечение также восстановило нормальное соотношение Th1/Th2 [7,98].…”

Section: изменения микробиоты при заболеваниях кожиunclassified

Микробиота Кожи И Возможности Ее Коррекции Пре- И Пробиотиками При Лечении Хронических Дерматозов

Litus¹,

Martyniuk²,

Bardova³

2017

Inter. jour. antoboit. and probiot.

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В последнее время достигнут прогресс в понимании значения микробиома для здоровья человека и его роли в развитии заболеваний. Изучение изменений микробиоты кожи при хронических дерматозах помогает понять этиологию и патогенез заболеваний, что важно для разработки стратегии лечения. Перспективным направлением является применение пре- и пробиотиков для модуляции кожной микробиоты с целью улучшения состояния кожи.

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Effects of Bifidobacterial Supplementation to Pregnant Women and Infants in the Prevention of Allergy Development in Infants and on Fecal Microbiota

Abstract: These data suggest that the prenatal and postnatal supplementation of bifidobacteria is effective in primary preventing allergic diseases. Some limited changes in the composition of fecal microbiota by the bifidobacterial supplementation were observed.

Cited by 142 publications

References 42 publications

Dietary Fiber and Bacterial SCFA Enhance Oral Tolerance and Protect against Food Allergy through Diverse Cellular Pathways

Dietary Fiber and Bacterial SCFA Enhance Oral Tolerance and Protect against Food Allergy through Diverse Cellular Pathways

Systems biology of asthma and allergic diseases: A multiscale approach

Микробиота Кожи И Возможности Ее Коррекции Пре- И Пробиотиками При Лечении Хронических Дерматозов

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