Effects of Biocompatible versus Standard Fluid on Peritoneal Dialysis Outcomes

Higher Dialysate Matrix Metalloproteinase-2 Levels are Associated with Peritoneal Membrane Dysfunction

“…The baseline characteristics of this subgroup were comparable to those of the original balANZ trial cohort (15). The median number of samples analyzed for patients during the study period was 4 (interquartile range: 2 -5).…”

“…Data were obtained from the participants of the balANZ trial (ACTRN12606000044527) (15). Detailed description of the study design and methodology has been previously published (16), as have the results of the main primary and secondary analyses (15,17,18).…”

Difficult peritonitis cases in children undergoing chronic peritoneal dialysis: relapsing, repeat, recurrent and zoonotic episodes

“…However, available data are controversial. In the BALANZ trial, a multicenter, open-labeled, randomized clinical trial of PD patients in Australia and New Zealand, the use of biocompatible compared with conventional PD solutions was associated with a reduction of the overall peritonitis rate (0.30 vs. 0.49 episodes per patient-year) [6]. In contrast, a prospective longitudinal follow-up of almost 4,000 PD patients found no difference in peritonitis rate between newer, biocompatible PD solutions and conventional solutions [7].…”

Is the Effect of Low-Gdp Solutions on Residual Renal Function Mediated by Fluid State? An Enigmatic Question which Still Needs to be Solved

“…In the largest randomized controlled study on this subject, after an increase in the D/P creatinine ratio in the short term, low-GDP solutions were associated with a stabilization of peritoneal membrane function as compared to standard solutions (17,18). Importantly, peritoneal ultrafiltration volume is generally found to be higher with conventional as compared to low-GDP solutions of the same glucose concentrations (17,19). Although the underlying mechanisms have not been fully elucidated, more pronounced vasodilation and peritoneal capillary recruitment with conventional solutions may be implicated (20).…”

“…Where there is ample evidence for a beneficial effect of low-GDP fluids on cell viability, as well as on peritoneal membrane structure and function from experimental trials, long-term data in humans are more scarce (15,16). In the largest randomized controlled study on this subject, after an increase in the D/P creatinine ratio in the short term, low-GDP solutions were associated with a stabilization of peritoneal membrane function as compared to standard solutions (17,18). Importantly, peritoneal ultrafiltration volume is generally found to be higher with conventional as compared to low-GDP solutions of the same glucose concentrations (17,19).…”