Effects of bioflavonoid ternatin on liver regeneration and oxidative stress in rats

Melo, José Ulisses de Souza; Melo, Radamés Bezerra; Santos, Jefferson Menezes Viana; Júnior, Manoel Messias Campos; Guimarães, Sérgio Botelho; Vasconcelos, Paulo Roberto Leitão de

doi:10.1590/s0102-86502013000600006

Cited by 8 publications

(5 citation statements)

References 27 publications

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“…Similar findings were verified with the use of other plant extracts as Hyptis pectinata 7 , Sida cordifolia 24 , Hyptis fruticos 11 and Peumus boldus 25 . This positive effect on proliferation of hepatocytes may be related with the antioxidant property of flavonoids, since they regulate the activities of antioxidant enzymes, modulate nuclear receptors and act on gene expression 26 .…”

Section: ■ Discussionmentioning

confidence: 99%

Effect of aqueous extract of the leaves of Baccharis trimera on the proliferation of hepatocytes after partial hepatectomy in rats

Lima

Figueiredo²,

Santana³

et al. 2017

Acta Cir. Bras.

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Section: ■ Discussionmentioning

confidence: 99%

Effect of aqueous extract of the leaves of Baccharis trimera on the proliferation of hepatocytes after partial hepatectomy in rats

Lima

Figueiredo²,

Santana³

et al. 2017

Acta Cir. Bras.

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“…However, GSH was increased during the later phase after PH, which may stimulate hepatocytes to shift from G0 to G1 phase of the cell cycle [22]. The lipid peroxidation inhibitory effects of several flavonoids such as luteolin, apigenin, galangin, gardenin D, (+)catechin, QE, rutin (quercetin-3-rhamnosyl glucoside) and biflavonoid ternatin have been previously reported [34]. Our results further showed a remarkable protective effect of QE, as indicated by restoring SOD activity, inhibiting GSH depletion, and alleviation of lipid peroxidation.…”

Section: A B Cmentioning

confidence: 94%

The effects of quercetin on liver regeneration after liver resection in rats

Kanter

Tuncer²,

Erboğa³

et al. 2016

Folia Morphol

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“…For the estimation of oxidative stress in the liver, snap-frozen tissue was used. Lipid peroxidation as malondialdehyde (MDA) was measured in liver homogenates using the thiobarbituric acid reactive substances (TBARS) method (Melo et al, 2013). Superoxide dismutase (SOD) activity was assessed by McCord and Fridovich method in the liver homogenates (Wheeler et al, 1990).…”

Section: Methodsmentioning

confidence: 99%

Anti-obesity Effects of Triphala at Biochemical and Molecular Level in High-Fat Diet-induced Obese Rats

Bhalerao,

Joshi,

Khadke

et al. 2023

Pharmacognosy Magazine

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Background The prevalence of obesity is rising worldwide. Due to the side effects associated with modern drugs, there is a need for an alternative treatment for obesity management. Triphala (TP), a polyherbal formulation from Ayurveda, is used by Ayurvedic physicians for weight loss. Purpose This study was designed to evaluate the effects of TP on obesity at the biochemical, histological, and molecular levels. Materials and Methods Male Wistar rats (125–150 g, 6–7 weeks old) were fed with a high-fat diet (HFD) for total of 48 days. From day 24 to day 48, along with HFD, rats were given an aqueous extract of TP (50, 100, and 200 mg/kg/day) or atorvastatin (1.2 mg/kg/day). Biochemical parameters were estimated in serum. Histopathology was done for the liver and adipose tissue. Levels of the genes involved in lipid metabolism were determined by quantitative real-time polymerase chain reaction (qRT-PCR). Monoamine levels were estimated from the brain tissue. Results At the end of the study (day 48), compared to only HFD receiving group (DC), all TP-treated groups showed a significant decrease in body weight, serum glucose, total cholesterol, triglycerides, leptin, interleukin-6, C-reactive protein, malondialdehyde, and noradrenaline levels. High-density lipoprotein, adiponectin, superoxide dismutase, serotonin, and dopamine levels were found to be increased compared to DC rats. Expression of various genes involved in lipid metabolism was found to be down regulated only in TP 100 group compared with DC. Additionally, all TP groups showed a reduction in adipocyte size and restored monoamine levels. Conclusion The aqueous extract of TP had shown an anti-obesity effect as demonstrated by lowering inflammation and oxidative stress, adipocyte size, and modulation of expression of genes involved in lipid metabolism.

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Effects of bioflavonoid ternatin on liver regeneration and oxidative stress in rats

Abstract: Intraperitoneal bioflavonoid ternatin injection in partially hepatectomized rats induces a decrease in oxidative stress and a significant hypoglycemic state, but does not promote any change in the evolution of liver regeneration.

Cited by 8 publications

References 27 publications

Effect of aqueous extract of the leaves of Baccharis trimera on the proliferation of hepatocytes after partial hepatectomy in rats

Effect of aqueous extract of the leaves of Baccharis trimera on the proliferation of hepatocytes after partial hepatectomy in rats

The effects of quercetin on liver regeneration after liver resection in rats

Anti-obesity Effects of Triphala at Biochemical and Molecular Level in High-Fat Diet-induced Obese Rats

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