Effects of biomimetic micropattern on titanium deposited with PDA/Cu and nitric oxide release on behaviors of ECs

Ma, Wenyong; Liu, Luying; Luo, Xiao; Han, Congzhen; Yang, Ping; Zhao, Yuancong; Huang, Nan

doi:10.1557/jmr.2019.166

Cited by 9 publications

(4 citation statements)

References 43 publications

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“…Furthermore, HR tests revealed that LDH/PDA/Hep coating had a low HR (0.65%) in vitro, implying that heparinization was a promising strategy to enhance the hemocompatibility of samples. Li et al [ 242 ] conjugated the Hep molecule, the Arg–Glu–Asp–Val peptide (REDV, which is a tetrapeptide derived from fibronectin that can be specifically recognized by α 4 β 1 integrin on the surface of ECs [ 243 ]), and an anti-CD 34 antibody (CD 34 is a highly glycosylated type I transmembrane glycoprotein that interacts with anti-CD 34 antibodies and is an important way to promote EPC-targeted adhesion/capture [ 244 , 245 ]) on a silane-treated ZE21B alloy, for improving surface endothelialization. A blood compatibility test suggested that multi-functional coating effectively restrained platelet adhesion/activation and reduced the HR (<5%).…”

Section: Surface Modification Of Mg Alloy Stentsmentioning

confidence: 99%

Advances in coatings on magnesium alloys for cardiovascular stents – A review

Zhang

Yang

et al. 2021

Bioactive Materials

109

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Magnesium (Mg) and its alloys, as potential biodegradable materials, have drawn wide attention in the cardiovascular stent field because of their appropriate mechanical properties and biocompatibility. Nevertheless, the occurrence of thrombosis, inflammation, and restenosis of implanted Mg alloy stents caused by their poor corrosion resistance and insufficient endothelialization restrains their anticipated clinical applications. Numerous surface treatment tactics have mainly striven to modify the Mg alloy for inhibiting its degradation rate and enduing it with biological functionality. This review focuses on highlighting and summarizing the latest research progress in functionalized coatings on Mg alloys for cardiovascular stents over the last decade, regarding preparation strategies for metal oxide, metal hydroxide, inorganic nonmetallic, polymer, and their composite coatings; and the performance of these strategies in regulating degradation behavior and biofunction. Potential research direction is also concisely discussed to help guide biological functionalized strategies and inspire further innovations. It is hoped that this review can give assistance to the surface modification of cardiovascular Mg-based stents and promote future advancements in this emerging research field.

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Section: Surface Modification Of Mg Alloy Stentsmentioning

confidence: 99%

Advances in coatings on magnesium alloys for cardiovascular stents – A review

Zhang

Yang

et al. 2021

Bioactive Materials

109

View full text Add to dashboard Cite

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“…Fibronectin coating can enhance migration of some cell types but not of some other types . Heparin, which is used to develop heparinized surfaces, can promote migration of endothelial cells (ECs) but inhibit that of smooth muscle cells (SMCs). , Some peptides like REDV (Arg–Glu–Asp–Val) have been reported to selectively promote endothelial cell layer formation on stent surfaces rather than other cell types. , Nitric oxide (NO) donors, which can be immobilized on micropatterned surfaces to provide biological signal molecules, can inhibit migration of SMCs but enhance migration of ECs . Nevertheless, available tools to adjust cell migration are still very limited.…”

Section: Introductionmentioning

confidence: 99%

“…11,12 Nitric oxide (NO) donors, which can be immobilized on micropatterned surfaces to provide biological signal molecules, can inhibit migration of SMCs but enhance migration of ECs. 13 Nevertheless, available tools to adjust cell migration are still very limited. What's more, the reported ways can only regulate the relative migration speed in a unidirectional manner, namely, either enlarged or reduced via one tool.…”

Section: Introductionmentioning

confidence: 99%

Enlargement, Reduction, and Even Reversal of Relative Migration Speeds of Endothelial and Smooth Muscle Cells on Biomaterials Simply by Adjusting RGD Nanospacing

Liu

Zheng

et al. 2021

ACS Appl. Mater. Interfaces

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Although many tissue regeneration processes after biomaterial implantation are related to migrations of multiple cell types on material surfaces, available tools to adjust relative migration speeds are very limited. Herein, we put forward a nanomaterial strategy to employ surface modification with arginine–glycine–aspartate (RGD) nanoarrays to tune in vitro cell migration using endothelial cells (ECs) and smooth muscle cells (SMCs) as demonstrated cell types. We found that migrations of both cell types exhibited a nonmonotonic trend with the increase of RGD nanospacing, yet with different peaks74 nm for SMCs but 95 nm for ECs. The varied sensitivities afford a facile way to regulate the relative migration speeds. Although ECs migrated at a speed similar to SMCs on a non-nano surface, the migration of ECs could be controlled to be significantly faster or slower than SMCs simply by adjusting the RGD nanospacing. This study suggests a potential application of surface modification of biomaterials on a nanoscale level.

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“…Likewise, TNT‐P12Cu3 showed negligible changes compared with TNT‐P12 from FTIR spectrum in Figure 2b, revealing PDA films successfully deposited on TNT surfaces. The absorption peak of 1680 cm −1 is attributed to the stretching vibrational peak of C=O in the amide bond, while the multiple consecutive absorption peaks in the 1640 cm −1 ‐1540 cm −1 range belong to the benzene ring skeleton vibrational peaks [32].…”

Section: Resultsmentioning

confidence: 99%

Tunable catalytic release of nitric oxide via copper‐loaded coatings on titanium nanotubes for regulating biological performance

Li,

Zhang,

Zhou

et al. 2023

Biosurface and Biotribology

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Severe lesions in vessels need to be treated with implantable interventional devices such as vascular stents, which should be anti‐coagulantion, anti‐proliferation and promoting endothelialisation. Nitric oxide (NO), as a physiological gas signalling molecule, play an important role in revascularisation. Catalysing the release of NO from endogenous donors has already been widely favoured to treatment strategy for lesioned vessels. In this work, a series of copper‐loaded coatings (titanium nanotube (TNT)/PDA‐Cu) was fabricated by TNTs combined with polydopamine and ions, which achieve controlled in situ catalytic release of NO. This strategy could effectively immobilised copper ions on TNTs, and promoted the proliferation of endothelial cells and inhibited growth of smooth muscle cells (SMCs) via the performance of NO, as well as restrain the platelet adhesion. With the multiple function, TNT/PDA‐Cu provides a promise approach for promoting endothelialisation, anti‐coagulation and inhibition of SMC proliferation via copper‐loaded coatings on TNTs.

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Effects of biomimetic micropattern on titanium deposited with PDA/Cu and nitric oxide release on behaviors of ECs

Abstract: Abstract

Cited by 9 publications

References 43 publications

Advances in coatings on magnesium alloys for cardiovascular stents – A review

Advances in coatings on magnesium alloys for cardiovascular stents – A review

Enlargement, Reduction, and Even Reversal of Relative Migration Speeds of Endothelial and Smooth Muscle Cells on Biomaterials Simply by Adjusting RGD Nanospacing

Tunable catalytic release of nitric oxide via copper‐loaded coatings on titanium nanotubes for regulating biological performance

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