Effects of biotin and nicotinamide supplementation on glucose and lipid metabolism and milk production of transition dairy cows

Wei, Xiao Shi; Cai, Chuanjiang; He, Jia Jun; Yu, Chao; Liu, Bao Long; Yao, Jun; Cao, Yangchun

doi:10.1016/j.anifeedsci.2018.01.012

Cited by 19 publications

(33 citation statements)

References 59 publications

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“…The production of ATP would be depressed when the expression of complex I, , and decreased [20]. The NAM supplementation caused an elevation in both mitochondrial respiration and ATP production, also supporting the results of improved NEB by NAM in our previous report [5].…”

Section: Discussionsupporting

confidence: 88%

“…During perinatal period, about 70% glucose was provided from hepatic gluconeogenesis [12]. Our previous studies have shown that NAM supplementation would relieve NEB [5] through improving glucose circulation [4]. The propionic acid is the main source of liver gluconeogenic substrate, and the ruminal propionic acid ratio was increased with NAM supplementation, suggesting the improved gluconeogenesis might be due to increased gluconeogenic substrate.…”

Section: Discussionmentioning

confidence: 99%

“…Nicotinamide (NAM) is the amide form of vitamin B3 and required for the synthesis of NAD and NADP, participating in many redox reactions. Our previous studies have shown that supplementing both NAM and biotin to transition dairy cows improved the energy balance, mainly through regulating glucose and lipid metabolism thus increasing the ATP production [4,5]. Mitchell et al [6] has proven that NAM could improve glucose metabolism by increasing glycogen deposition and ux through the pentose phosphate and glycolytic pathways.…”

Section: Introductionmentioning

confidence: 99%

“…Mitchell et al [6] has proven that NAM could improve glucose metabolism by increasing glycogen deposition and ux through the pentose phosphate and glycolytic pathways. Moreover, the NAM was also proven to alleviate oxidative stress through decreasing NEFA, and β-hydroxybutyric acid, ROS, and improving glutathione metabolism in transition dairy cows [4,5]. The improved energy balance and health status then bene tted the offspring kids on small intestine morphology and function, and the hepatic glucose and lipid metabolism [7,8].…”

Section: Introductionmentioning

confidence: 99%

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Regulation of Nutritional Metabolism in Different Perinatal Period of Does: Energy Metabolism Efficiency, Lipid Metabolism, Oxidative Stress and Liver Metabolomics Profile in Response to Nicotinamide Supplementation

Wei

Yin

Zhao

et al. 2020

Preprint

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Background: Improving energy efficiency is urgent during perinatal period because dairy ruminant is often in negative energy balance, resulting many metabolic disorders thus economic losses. It has been previously highlighted that nicotinamide (NAM) supplementation during perinatal period could benefit the energy balance, while the underlying metabolic alterations and the differences in NAM supplemented during different perinatal period have been poorly studied. This study aimed to elucidate the effects of NAM on energy efficiency, lipid metabolism, oxidative status, and liver metabolites profile of perinatal does during different perinatal period. Results: Fifteen multiparous does with similar parity, weight, and previous milk yield were paired and allocated to 3 groups (n = 5): control (C), postpartum supplementation (P, NAM supplemented after kidding), and entire-perinatal supplementation (EP, NAM supplemented from -21 to 28 d around kidding). Does were drenched with 5 g/d of NAM and slaughtered on d 28. The ruminal acetic acid tended to decrease, and the propionic acid and valeric acid were increased in P and EP. The does in P and EP had a decreased acetic acid to propionic acid ratio. Does in EP had higher liver mitochondrial respiratory chain complexes. The Complex Ⅱ was elevated in both P and EP and NAM supplementation tended to increase ATP production. Liver metabolomics analysis and tissues biochemical analysis revealed that lipid was decomposed in abdominal adipose, and in liver, the decomposition of lipid was more than the synthesis, and the amino acid metabolism were enriched by NAM. Moreover, the oxidative status of blood and liver were improved by NAM supplementation, and supplementation of NAM during postpartum only does not appear enough to cope with the metabolites of oxidative phosphorylation. Conclusions: Overall, these data suggested that NAM supplementation during perinatal period favored the rumen fermentation pattern to propionic acid-type, and improved liver energy efficiency with benefited lipid metabolism. The NAM supplemented from prepartum is needed for better oxidative status and energy metabolism of perinatal does.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Regulation of Nutritional Metabolism in Different Perinatal Period of Does: Energy Metabolism Efficiency, Lipid Metabolism, Oxidative Stress and Liver Metabolomics Profile in Response to Nicotinamide Supplementation

Wei

Yin

Zhao

et al. 2020

Preprint

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“…Circulating NEFA is an important indicator of adipose mobilisation and metabolic health in dairy cows (43) . In some studies (44)(45)(46) , supplementation of nicotinic acid, RPN or nicotinamide during transition periods was reported to decrease the plasma NEFA concentration, but in some other studies (17,47,48) supplementation had no influence (Table 4). Additionally, Morey et al (16) reported that 12 g/d RPN supplementation in early lactation decreased peak plasma NEFA concentration but did not affect the average plasma NEFA concentration.…”

Section: Metabolic Statusmentioning

confidence: 99%

Niacin nutrition and rumen-protected niacin supplementation in dairy cows: an updated review

2019

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As the precursor to NAD+ and NADP+, niacin is important for catabolic and anabolic redox reactions. In addition, niacin is known for its anti-lipolytic action via a hydroxycarboxylic acid-2-receptor-dependent mechanism. The anti-lipolytic effects of traditional free niacin supplementation during transition periods had been studied extensively, but the reported effects are ambiguous. In the past decade, a series of studies were conducted to evaluate the effects of rumen-protected niacin (RPN) on production performance and metabolic status in early lactation and on heat stress in dairy cows. Feeding RPN seems more effective than free niacin regarding increasing circulating niacin concentration. The rebound of plasma NEFA was found after termination of niacin abomasal infusion. Feeding RPN or infusion of niacin via the abomasum could suppress lipolysis and reduce insulin resistance in early lactation. Additionally, RPN supplementation could possibly relieve heat stress through vasodilation during moderate to severe heat stress condition. However, these beneficial effects of niacin supplementation have not always been observed. The inconsistent results across studies may be related to dosages of niacin supplementation, rebound of plasma NEFA concentration, stage of lactation or severity of heat stress. Overall, the current review is to present updated information on niacin nutrition in dairy cows and the recommendations are given for future research.

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Additives and Nutritional Supplements for Transition Cows

Kour,

Sharma,

Sharma

et al. 2024

Feed Additives and Supplements for Ruminants

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Effects of biotin and nicotinamide supplementation on glucose and lipid metabolism and milk production of transition dairy cows

Cited by 19 publications

References 59 publications

Regulation of Nutritional Metabolism in Different Perinatal Period of Does: Energy Metabolism Efficiency, Lipid Metabolism, Oxidative Stress and Liver Metabolomics Profile in Response to Nicotinamide Supplementation

Regulation of Nutritional Metabolism in Different Perinatal Period of Does: Energy Metabolism Efficiency, Lipid Metabolism, Oxidative Stress and Liver Metabolomics Profile in Response to Nicotinamide Supplementation

Niacin nutrition and rumen-protected niacin supplementation in dairy cows: an updated review

Additives and Nutritional Supplements for Transition Cows

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