Effects of biotin on pyruvate carboxylase, acetyl-CoA carboxylase, propionyl-CoA carboxylase, and markers for glucose and lipid homeostasis in type 2 diabetic patients and nondiabetic subjects

Abstract

The activity of carboxylases does not differ significantly between type 2 diabetic and nondiabetic subjects. Pharmacologic doses of biotin increase lymphocyte PCC, PC, and ACC activities.

Optimization of Medium Components for β-glucosidase Production in Schizophyllum commune KUC9397 and Enzymatic Hydrolysis of Lignocellulosic Biomass

“…Many researchers have reported that the presence of vitamins influences the rate of biosynthesis of many metabolites and increases enzyme activities (Báez-Saldaña et al 2004;Chen et al 2004;Deswal et al 2011;Lee et al 2001). Additionally, vitamins are easy to deliver during liquid fermentation (Joo et al 2009).…”

Literature search and review related to specific preparatory work in the establishment of Dietary Reference Values for Niacin, Biotin and Vitamin B6

“…Two papers investigated the biotin intake and status relationship (Mock et al 2002, Baez-Saldana et al 2004. Biotin administration increased lymphocyte PCC, PC and ACC activity in both diabetics and non-diabetics (Baez-Saldana et al 2004).…”

“…No information on reproducibility of test measurements, small study population (Baez-Saldana et al 2004).…”

“…In a randomized double-blind placebo-controlled trial of Báez-Saldana et al, two small studies were conducted (Baez-Saldana et al 2004). The aim of the first study was to compare the propionyl CoA carboxylase (PCC), acetyl-CoA carboxylase (ACC) and pyruvate carboxylase (PC) activity in lymphocytes and other plasma metabolites between 30 non-diabetic and 24 type 2-diabetic patients (Baez-Saldana et al 2004).…”

“…The aim of the first study was to compare the propionyl CoA carboxylase (PCC), acetyl-CoA carboxylase (ACC) and pyruvate carboxylase (PC) activity in lymphocytes and other plasma metabolites between 30 non-diabetic and 24 type 2-diabetic patients (Baez-Saldana et al 2004). No significant correlation was observed between fasting glucose concentrations and PCC activity in either of the groups (overall r=0.182) and no significant correlation between fasting glucose concentrations and the activities of these 2 carboxylases was found in either of the groups (fasting glucose and ACC: overall r= -0.0128; fasting glucose and PC: overall r= -0.0644).…”