Effects of Bisaramil on Coronary-Occlusion-Reperfusion Injury and Free-Radical-Induced Reactions

Paróczai, M; Röth, Elizabeth; Matos, Gabor; Temes, G; Lantos, János; Kárpáti, E

doi:10.1006/phrs.1996.0045

Cited by 12 publications

(4 citation statements)

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“…Erythrocytes were washed with isotonic solution of sodium chloride and centrifuged at 3000 r/min for 10 min where erythrocyte pellets were separated and resuspended in cold distilled water to obtain the erythrocyte lysate. 50,51 The resulting erythrocyte lysate was used for measurement of SOD and determination of GSH-Px. 52 The GSH-Px activity was given as IU/mL and SOD activity as U/mL.…”

Section: Methodsmentioning

confidence: 99%

Antioxidant effect of garlic (Allium sativum) and black seeds (Nigella sativa) in healthy postmenopausal women

et al. 2013

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Objectives:The objective of this study is to investigate the antioxidant effects of garlic extract and crude black seeds’ consumption on blood oxidant/antioxidant levels in healthy postmenopausal women.Methods:In total, 30 healthy postmenopausal women (mean age = 50.31 ± 4.23 years) participated. They ingested two garlic soft gels per day (each is equivalent to 1000 mg of fresh garlic bulb) and crude black seed grounded to powder in a dose of 3 g/day for 8 weeks. Oxidant (malondialdehyde) activity in plasma and antioxidants superoxide dismutase and glutathione peroxidase activities in erythrocytes were studied.Results:Significant low levels of plasma malondialdehyde with increased erythrocyte glutathione peroxidase and superoxide dismutase activities.Discussion:Menopause is associated with an increase in oxidative stress and a decrease in some antioxidant parameters. Consumption of garlic extracts and crude black seeds may have a beneficial effect on improved balance between blood oxidants and antioxidants in healthy postmenopausal women.

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Section: Methodsmentioning

confidence: 99%

Antioxidant effect of garlic (Allium sativum) and black seeds (Nigella sativa) in healthy postmenopausal women

et al. 2013

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“…Although restoration of blood flow is the only way to save the myocardium from necrosis, reperfusion-induced injury is at the background of a high mortality rate [1]. Extensive studies showed that myocardial ischemia-reperfusion (I/R) injury is associated with increased generation of reactive oxygen species (ROS).…”

Section: Introductionmentioning

confidence: 99%

Natural Antioxidant-Isoliquiritigenin Ameliorates Contractile Dysfunction of Hypoxic Cardiomyocytes via AMPK Signaling Pathway

Zhang

Zhu

Zhang

et al. 2013

Mediators of Inflammation

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Isoliquiritigenin (ISL), a simple chalcone-type flavonoid, is derived from licorice compounds and is mainly present in foods, beverages, and tobacco. Reactive oxygen species (ROS) is a critical factor involved in modulating cardiac stress response signaling during ischemia and reperfusion. We hypothesize that ISL as a natural antioxidant may protect heart against ischemic injury via modulating cellular redox status and regulating cardioprotective signaling pathways. The fluorescent probe H2DCFDA was used to measure the level of intracellular ROS. The glucose uptake was determined by 2-deoxy-D-glucose-3H accumulation. The IonOptix System measured the contractile function of isolated cardiomyocytes. The results demonstrated that ISL treatment markedly ameliorated cardiomyocytes contractile dysfunction caused by hypoxia. ISL significantly stimulated cardioprotective signaling, AMP-activated protein kinase (AMPK), and extracellular signal-regulated kinase (ERK) signaling pathways. The ROS fluorescent probe H2DCFDA determination indicated that ISL significantly reduced cardiac ROS level during hypoxia/reoxygenation. Moreover, ISL reduced the mitochondrial potential (Δψ) of isolated mouse cardiomyocytes. Taken together, ISL as a natural antioxidant demonstrated the cardioprotection against ischemic injury that may attribute to the activation of AMPK and ERK signaling pathways and balance of cellular redox status.

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“…Each of these clinically relevant phenomena has been associated with release of reactive oxygen species from recruited polymorphonuclear neutrophils (PMN). [1][2][3] PMN adhesion may occur rapidly after onset of ischemia. Accordingly, early bolus application of adhesion antagonists, eg CD18 antibodies or selectin antagonists, reduces myocardial detriment after 3-6 h of reperfusion.…”

Section: Introductionmentioning

confidence: 99%

Retroinfusion of NFκB decoy oligonucleotide extends cardioprotection achieved by CD18 inhibition in a preclinical study of myocardial ischemia and retroinfusion in pigs

Kupatt¹,

Wichels²,

Deiss³

et al. 2002

Gene Ther

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Effects of Bisaramil on Coronary-Occlusion-Reperfusion Injury and Free-Radical-Induced Reactions

Cited by 12 publications

References 0 publications

Antioxidant effect of garlic (Allium sativum) and black seeds (Nigella sativa) in healthy postmenopausal women

Antioxidant effect of garlic (Allium sativum) and black seeds (Nigella sativa) in healthy postmenopausal women

Natural Antioxidant-Isoliquiritigenin Ameliorates Contractile Dysfunction of Hypoxic Cardiomyocytes via AMPK Signaling Pathway

Retroinfusion of NFκB decoy oligonucleotide extends cardioprotection achieved by CD18 inhibition in a preclinical study of myocardial ischemia and retroinfusion in pigs

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