Effects of blood‐flow‐restricted resistance training on muscle function in a 74‐year‐old male with sporadic inclusion body myositis: a case report

Jørgensen, Anders Nørkær; Aagaard, Per; Nielsen, Jakob Lindberg; Diederichsen, Louise Pyndt

doi:10.1111/cpf.12259

Cited by 31 publications

(43 citation statements)

References 34 publications

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“…These data might partially explain the increase in muscle mass observed in the aforementioned case study [36]. Corroborating the previous findings, Jorgensen et al [38] examined a 74-year-old man with who participated in strength training combined with partial blood flow restriction over a 12week period. These authors observed substantial increases in mechanical muscle strength and gait speed, suggesting that this type of training reverses the losses in strength and functional capacity associated with these patients.…”

Section: Physical Exercise In Patients With Ibmmentioning

confidence: 59%

Physical exercise among patients with systemic autoimmune myopathies

et al. 2018

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Systemic autoimmune myopathies (SAMs) are a heterogeneous group of rare systemic autoimmune diseases that primarily affect skeletal muscles. Patients with SAMs show progressive skeletal muscle weakness and consequent functional disabilities, low health quality, and sedentary lifestyles. In this context, exercise training emerges as a non-pharmacological therapy to improve muscle strength and function as well as the clinical aspects of these diseases. Because many have feared that physical exercise exacerbates inflammation and consequently worsens the clinical manifestations of SAMs, it is necessary to evaluate the possible benefits and safety of exercise training among these patients. The present study systematically reviews the evidence associated with physical training among patients with SAMs.

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Section: Physical Exercise In Patients With Ibmmentioning

confidence: 59%

Physical exercise among patients with systemic autoimmune myopathies

et al. 2018

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“…Low-load resistance training combined with blood flow restriction (BFR) has challenged traditional beliefs that loads superior to 65% of one-repetition maximum (1-RM) are required to elicit significant increases in muscle size and strength (American College of Sports Medicine [ACSM], 2011). In fact, previous studies have demonstrated that BFR resistance exercise is capable of eliciting muscle hypertrophy gains and muscle function improvements across a variety of populations (Takarada et al, 2000b;Yasuda et al, 2014;Buford et al, 2015;Jørgensen et al, 2015;Tennent et al, 2017). The inclusion of training loads as low as 20-30% of 1-RM has made BFR resistance exercise alluring as a potential training alternative to conventional high-load resistance training, which may benefit those unable to lift heavy loads.…”

Section: Introductionmentioning

confidence: 99%

Acute Physiological Responses to Resistance Exercise With Continuous Versus Intermittent Blood Flow Restriction: A Randomized Controlled Trial

et al. 2020

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The primary goal of this investigation was to examine the physiological responses of blood flow restriction (BFR) resistance exercise (RE) performed with continuous or intermittent BFR and to compare these results to those from conventional high-and low-load RE without BFR. Fourteen men randomly completed the following experimental trials: (1) low-load RE with continuous BFR (cBFR), (2) low-load RE with intermittent BFR (iBFR), (3) low-load RE without BFR (LI), and (4) conventional high-load RE without BFR (HI). For the cBFR, iBFR, and LI exercise trials, participants performed four sets of 30-15-15-15 repetitions of the bilateral leg press (LP) and knee extension (KE) exercises, at an intensity of 20% of their one-repetition maximum (1-RM), at a 1.5s contraction speed, and with a 1-min rest period between sets. The only difference between the cBFR and iBFR protocols was that the pressure of the cuffs was released during the rest intervals between sets for the iBFR trial. For the HI trial, participants completed four sets of 10 repetitions of the same exercises, at 70% of 1-RM, with a 1-min rest period between sets, and at the same contraction speed. Muscle activity was assessed during each set using superficial electromyography, as well as changes in blood lactate concentration [La − ] from baseline at 5 min post exercise and in muscle swelling and plasma volume (% PV) at 5 and 15 min post exercise. There were no significant differences in muscle activity (p < 0.05) across the cBFR, iBFR, and LI protocols at any time point, whereas they were all significantly lower than HI. There were also no significant (p < 0.05) differences across the three low-load RE conditions for [La − ],% PV, or muscle swelling. HI elicited significantly (p < 0.05) greater responses than cBFR, iBFR, and LI for all the physiological markers measured. In conclusion, RE combined with cBFR or iBFR induce the same acute physiological responses. However, the largest physiological responses are observed with HI, probably because of the significantly greater exercise volumes. Therefore, releasing the pressure of the restrictive cuffs during the rest periods between sets will not hinder the acute physiological responses from BFR RE.

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“…In addition, weakness of the thigh's quadriceps muscles, increased serum CK level, the presence of RVs and atrophic myofibers in muscle biopsies could help to diagnose patients suffering from s-IBM [9,31]. There are some reports showing that physical effort may improve skeletal muscle strength and function, which would encourage its implementation immediately after s-IBM has been diagnosed [6,32]. Since s-IBM is an untreatable disease establishing the final diagnosis is critical for patients in order to avoid an ineffective immunosuppressive therapy with its many side effects [9,15], and to start physiotherapy [33].…”

Section: Discussionmentioning

confidence: 99%

Immunohistochemical and ultrastructural analysis of sporadic inclusion body myositis: a case series

et al. 2018

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Sporadic inclusion body myositis (s-IBM) is a progressive, skeletal muscle disease with poor prognosis. However, establishing the final diagnosis is difficult because of the lack of clear biomarkers in the blood serum and very slow development of clinical symptoms. Moreover, most other organs function normally without any disturbance. Here, in patients with this untreatable disease, we have underlined the importance of immunohistochemical and ultrastructural assessment of skeletal muscle in patients diagnosed with s-IBM. The goal of this study was to identify the distribution of specific antigens and to determine morphological features in order to localize pathological protein aggregates, rimmed vacuoles, and loss of myofibrils, which are key elements in the diagnosis of s-IBM. All studied patients were between 48 and 83 years of age and were hospitalized in the Department of Rheumatology and Internal Medicine between 2011 and 2016. Anamneses revealed an accelerated progression of muscle atrophy, weakness of limb muscles, and difficulties with climbing stairs. Based on histopathology and transmission electron microscopy examination, inflammatory infiltrations consisting of mononuclear cells, severe atrophy and focal necrosis of myofibers, splitting of myofilaments, myelinoid bodies and rimmed vacuoles were observed. Primary antibodies directed against CD3, CD8, CD68, cN1A, beta-amyloid, Tau protein and apolipoprotein B made it possible to identify types of cells within infiltrations as well as the protein deposits within myofibers. Using a combination of immunohistochemistry and electron microscopy methods, we were able to establish the correct final diagnosis and to implement a specific treatment to inhibit disease progression.

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Effects of blood‐flow‐restricted resistance training on muscle function in a 74‐year‐old male with sporadic inclusion body myositis: a case report

Cited by 31 publications

References 34 publications

Physical exercise among patients with systemic autoimmune myopathies

Physical exercise among patients with systemic autoimmune myopathies

Acute Physiological Responses to Resistance Exercise With Continuous Versus Intermittent Blood Flow Restriction: A Randomized Controlled Trial

Immunohistochemical and ultrastructural analysis of sporadic inclusion body myositis: a case series

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