2002
DOI: 10.1152/japplphysiol.00055.2002
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Effects of body position on intracranial and cerebral perfusion pressures in isoflurane-anesthetized horses

Abstract: Inhalant anesthetics may interfere with normal cerebrovascular autoregulation. It was, therefore, hypothesized that intracranial pressure (ICP) and cerebral perfusion pressure (CPP) in isoflurane-anesthetized horses would be especially sensitive to body and head position because of the potential for large hydrostatic gradients between the brain and heart in this species. Anesthesia was induced and maintained in six clinically healthy, unmedicated geldings with 1.57% isoflurane in O(2); mechanical ventilation w… Show more

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Cited by 47 publications
(48 citation statements)
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References 19 publications
(18 reference statements)
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“…24 Body position shows only an influence on global ICP levels. 25 ICP changes may be related to changes in abdominal pressure or organ displacement producing possible cranial displacement of the diaphragm, increased thoracic pressure, and external compression of the vena cava. 24 But neither head nor body position have any influence on focal ICP levels or intracranial ICP gradients.…”
Section: Experimental Conditionmentioning
confidence: 99%
“…24 Body position shows only an influence on global ICP levels. 25 ICP changes may be related to changes in abdominal pressure or organ displacement producing possible cranial displacement of the diaphragm, increased thoracic pressure, and external compression of the vena cava. 24 But neither head nor body position have any influence on focal ICP levels or intracranial ICP gradients.…”
Section: Experimental Conditionmentioning
confidence: 99%
“…Intracranial pressure in horses is clearly sensitive to changes in body and head position because of the potential for large hydrostatic gradients between the brain and heart in this species. 53 When horses ingesting fumonisin lower their heads to eat, we think they are more prone to developing cerebral edema from hydrostatically driven increased blood flow because of fumonisin blockade of normal vascular regulatory mechanisms.…”
Section: Discussionmentioning
confidence: 99%
“…55 More invasive diagnostic and monitoring modalities are available (Table 24.3). Methods to measure and monitor intracranial and cerebral perfusion pressures have been described for use in foals 56 and adult horses [57][58][59][60][61] ; however, these techniques have thus far not been scientifically evaluated in clinical cases. In human medicine, development of advanced bedside neuromonitoring devices has been an important focus in neurocritical care.…”
Section: Traumatic Brain Injurymentioning
confidence: 99%