Effects of Body Weight Reduction on Serum Irisin and Metabolic Parameters in Obese Subjects

Fukushima, Yaeko; Kurose, Satoshi; Shinno, Hiromi; Thu, Ha Cao Thi; Takao, Nana; Tsutsumi, Hiromi; Hasegawa, Takaaki; Nakajima, Toshiaki; Kimura, Yutaka

doi:10.4093/dmj.2016.40.5.386

Cited by 39 publications

(28 citation statements)

References 46 publications

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“…Skeletal muscle is considered an endocrine organ, and secretes various myokines such as irisin and IL‐6 . Irisin, induced by exercise, involves peroxisome proliferator‐activated receptor α signaling and plays a crucial role in fatty acid beta‐oxidation in the liver, which leads to improvement of hepatic steatosis and insulin sensitivity with upregulation of fibroblast growth factor 21 . Therefore, skeletal muscle may play a causative role in developing or improving NAFLD by secreting favorable myokines.…”

Section: Discussionmentioning

confidence: 99%

“…(41)(42)(43) Irisin, induced by exercise, involves peroxisome proliferator-activated receptor α signaling and plays a crucial role in fatty acid beta-oxidation in the liver, which leads to improvement of hepatic steatosis and insulin sensitivity with upregulation of fibroblast growth factor 21. (44)(45)(46) Therefore, skeletal muscle may play a causative role in developing or improving NAFLD by secreting favorable myokines. Furthermore, physical activity provides a link between relative skeletal muscle and NAFLD, as low muscle mass leads to physical disability, which reduces energy expenditures, increases obesity, and leads to hepatic steatosis.…”

Section: Discussionmentioning

confidence: 99%

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Relationship Between Relative Skeletal Muscle Mass and Nonalcoholic Fatty Liver Disease: A 7‐Year Longitudinal Study

et al. 2018

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Nonalcoholic fatty liver disease (NAFLD) has been associated with relative skeletal muscle mass in several cross-sectional studies. We explored the effects of relative skeletal muscle mass and changes in relative muscle mass over time on the development of incident NAFLD or the resolution of baseline NAFLD in a large, longitudinal, population-based 7-year cohort study. We included 12,624 subjects without baseline NAFLD and 2943 subjects with baseline NAFLD who underwent health check-up examinations. A total of 10,534 subjects without baseline NAFLD and 2631 subjects with baseline NAFLD were included in analysis of changes in relative skeletal muscle mass over a year. Subjects were defined as having NAFLD by the hepatic steatosis index, a previously validated NAFLD prediction model. Relative skeletal muscle mass was presented using the skeletal muscle mass index (SMI), a measure of body weight-adjusted appendicular skeletal muscle mass, which was estimated by bioelectrical impedance analysis. Of the 12,624 subjects without baseline NAFLD, 1864 (14.8%) developed NAFLD during the 7-year follow-up period. Using Cox proportional hazard analysis, compared with the lowest sex-specific SMI tertile at baseline, the highest tertile was inversely associated with incident NAFLD (adjusted hazard ratio [AHR] = 0.44, 95% confidence interval [CI] = 0.38-0.51) and positively associated with the resolution of baseline NAFLD (AHR = 2.09, 95% CI = 1.02-4.28). Furthermore, compared with the lowest tertile of change in SMI over a year, the highest tertile exhibited a significant beneficial association with incident NAFLD (AHR = 0.69, 95% CI = 0.59-0.82) and resolution of baseline NAFLD (AHR = 4.17, 95% CI = 1.90-6.17) even after adjustment for baseline SMI. Conclusion: Increases in relative skeletal muscle mass over time may lead to benefits either in the development of NAFLD or the resolution of existing NAFLD.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Relationship Between Relative Skeletal Muscle Mass and Nonalcoholic Fatty Liver Disease: A 7‐Year Longitudinal Study

et al. 2018

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“…Circulating myonectin linking skeletal muscle to lipid metabolism in the liver and adipose tissue provides insights into tissue cross-talk that underlies the integrated control of whole-body metabolism [28]. Hepatoprotective IL-6 [29] and irisin [30] are further reported to improve hepatic steatosis [31].…”

Section: Discussionmentioning

confidence: 99%

Companion-Intensive Multi-aspect Weight Management in Chinese Adults with Obesity: A Six-Month Multicenter Randomized Clinical Trial

Jiang

Huang

et al. 2020

Preprint

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Background Obesity is a globally increasing health epidemic requiring early lifestyle intervention. Our main objective was to examine the effectiveness of companion-intensive multi-aspect weight management (CIMWM) for Chinese adults with obesity. Methods In this 6-month, prospective, open-label, multicenter, randomized controlled clinical trial, we included 272 obese adults aged 18–50 years with a body mass index (BMI) ≥ 28.0 kg/m2 and capable of using smartphones. CIMWM (n = 136) offered both daily online instructions and monthly face-to-face guidance by physicians, dietitians, and health managers along with the provision of meal replacements in the first 3 months. Traditional multi-aspect weight management (TMWM, n = 136) provided monthly face-to-face guidance by the above-mentioned professionals and required daily self-monitoring. Measurements of body composition and metabolic parameters were assessed face-to-face at baseline, 1, 2, 3, and 6 months by physicians. Primary outcomes were the changes in BMI and body composition. Results All participants showed significantly reduced BMI, body fat mass (BFM), visceral fat area (VFA), and HOMA-IR (P < 0.05). CIMWM was shown to be superior to TMWM in the improvement of BMI, alanine aminotransferase (ALT), and the body composition parameters BFM and VFA (P < 0.05). The relationship of baseline non-alcoholic fatty liver disease score (NFS) was positively related to the skeletal muscle mass-to-visceral fat area ratio (S/V). Additionally, the weight management program was beneficial in lowering the NFS among subjects with levels in the highest tertile (P < 0.05). Metabolic memory in terms of the continuous reduction of BMI, VFA, and ALT was retained up to 6 months in spite of participants transferring to self-monitored assessment in the final 3 months. Conclusions The CIMWM strategy in obese Chinese adults proved to be more effective than TMWM, and motivates greater adherence to intervention and lifestyle reprogramming. Trial registration: ChiCTR1800017463, Registered 31 July 2018, retrospectively registry. http://www.chictr.org.cn/showproj.aspx?proj=29649

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“…Irizine, according to the authors, could be a therapeutic agent for the treatment of metabolic disorders and other diseases that can be controlled with exercise [161]. This discovery caused a stormy but very contradictory reaction in the scientific and medical community: from total enthusiasm in connection with the emergence of another "panacea" for the treatment of obesity to declaring all the beneficial effects of irisin described above as a myth [162][163][164][165].…”

Section: Can Brown Fat Defeat White In the Fight Against Obesity?mentioning

confidence: 99%

Nonspecific Energy Expenditure of the Body and Body Mass Regulation

Zagoskin

2019

JNB

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The principal possibility of nonspecific energy expenditure at all stages of the transformation of nutrients in the body is demonstrated. These stages include the processing of food in the mouth, digestion, absorption, interaction with the intestinal micro biome, and interstitial metabolic processes. Particular attention is paid to the role of nonspecific energy expenditure of the body in the regulation of body mass. The data on the pivotal role of reducing nonspecific energy expenditure in the development of obesity and associated pathological conditions are presented. The prospects for using uncouples of oxidative phosphorylation, fatty acids, carnitine, bile acids, sarcolipin and a number of other substances as regulators of the nonspecific energy expenditure and potential means of preventing and treating obesity are analyzed.

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Effects of Body Weight Reduction on Serum Irisin and Metabolic Parameters in Obese Subjects

Cited by 39 publications

References 46 publications

Relationship Between Relative Skeletal Muscle Mass and Nonalcoholic Fatty Liver Disease: A 7‐Year Longitudinal Study

Relationship Between Relative Skeletal Muscle Mass and Nonalcoholic Fatty Liver Disease: A 7‐Year Longitudinal Study

Companion-Intensive Multi-aspect Weight Management in Chinese Adults with Obesity: A Six-Month Multicenter Randomized Clinical Trial

Nonspecific Energy Expenditure of the Body and Body Mass Regulation

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