Effects of bone mineral density of the lumbar spine and prevalent vertebral fractures on the risk of immobility

Shiraki, Masataka; Kuroda, Tatsuhiko; Shiraki, Y.; Aoki, Choju; Sasaki, Kouichi; Tanaka, Shinya

doi:10.1007/s00198-009-1121-9

Cited by 28 publications

(17 citation statements)

References 27 publications

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“…Osteolytic bone diseases such as osteoporosis, rheumatoid arthritis, and periodontitis are becoming more and more serious medical problems as the populations in industrialized countries rapidly age [Cochran, ; Shiraki et al, ; Schett and Gravallese, ]. These disorders markedly reduce quality of life (QOL) and ability of daily living (ADL) of the patients, while significantly increasing medical and caring expenses.…”

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confidence: 99%

Generation of Directly Converted Human Osteoblasts That Are Free of Exogenous Gene and Xenogenic Protein

Yamamoto

Satô

Honjo

et al. 2016

J of Cellular Biochemistry

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Generation of osteoblasts from human somatic cells may be applicable in an effective transplantation therapy against bone diseases. Recently we established a procedure to directly convert human fibroblasts into osteoblasts by transducing some transcription factor genes via retroviral vectors. However, retroviral vector-mediated transduction may potentially cause tumor formation from the infected cells, thus a non-viral gene transfection method may be more preferable for preparation of osteoblasts to be used for transplantation therapy. Here, we constructed a plasmid vector encoding Oct4, Osterix, and L-Myc that were an appropriate combination of transcription factors for this purpose. Osteoblast-like phenotypes including high alkaline phosphatase (ALP) activity, bone matrix production and osteoblast-specific gene expression were induced in normal human fibroblasts that were transfected with the plasmid followed by culturing in osteogenic medium. The plasmid-driven directly converted osteoblasts (p-dOBs) were obtained even in the absence of a xenogenic protein. The plasmid vector sequence had fallen out of the p-dOBs. The cells formed deposition of calcified bodies in situ after transplantation into mice. These results strongly suggest that p-dOBs can be put into practical use for a novel cell-based therapy against bone diseases. J. Cell. Biochem. 117: 2538-2545, 2016. © 2016 Wiley Periodicals, Inc.

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mentioning

confidence: 99%

Generation of Directly Converted Human Osteoblasts That Are Free of Exogenous Gene and Xenogenic Protein

Yamamoto

Satô

Honjo

et al. 2016

J of Cellular Biochemistry

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“…Together with our recent report that showed that osteoporosis is a significant independent risk factor for immobility in Japanese women (31), osteoporosis should be recognized as a harmful disease which may affect the patient's prognosis.…”

Section: Discussionmentioning

confidence: 68%

Established Osteoporosis Associated with High Mortality after Adjustment for Age and Co-Mobidities in Postmenopausal Japanese Women

Shiraki¹,

Kuroda²,

Tanaka

2011

Intern. Med.

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Objective Osteoporosis has been reported to increase the risk of mortality. However, these reports did not evaluate the effects of co-mobidities and the severity of osteoporosis on mortality. The aim of our study was to determine whether or not major osteoporotic fractures contribute to the increased mortality risk in Japanese women. Method We conducted a prospective observational study. Risk factors contributing to mortality were assessed by Cox's proportional hazard model. Subjects A total of 1,429 ambulatory postmenopausal female volunteers aged over 50 years old were enrolled in the study. Information was obtained from the subjects on baseline biochemical indices, bone mineral density (BMD), prevalent fractures, and co-morbidities. Mortality was assessed and confirmed by the certificates or hospital records. The subjects were classified into three categories in accordance with or without osteoporosis. The osteoporotic group was further categorized by the basis of the presence or absence of major osteoporotic fractures. Results Mean age and SD of the participants were 66.5±9.3 (50-90) years old. The participants were followed for a total of 4.5±3.5 years (mean ± SD) and a total of 141 participants (9.9%) died during the observation. In addition to the traditional risks for mortality, such as age (Hazard ratio, 2.817, 95% CI, 2.237-3.560, p<0.0001), BMI (HR 0.504, 0.304-0.824, p=0.0061), prevalent malignancies (HR 2.885, 1.929-4.214, p<0.0001), dementia (HR 1.602, 1.027-2.450, p=0.038) and cardio-vascular disease (HR 1.878, 1.228-2.787, p=0.0043), the serum level of creatinine (HR 2.451, 1.107-5.284, p=0.027) and severity of osteoporosis (HR 1.390, 1.129-1.719, P=0.0018) were found to be significant independent risk factors for all-cause mortality. Conclusion These results emphasize the importance of osteoporotic fracture in terms of survival.

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“…However, serum markers for bone remodeling are usually decreased in patients with GH deficiency [15] whereas our patient showed increased turnover of bone metabolism. Otherwise, immobility can also negatively affect a patient's BMD [16]. It is also possible that TSH deficiency as well as hypothyroidism might affect the reduced BMD in our patient.…”

Section: Discussionmentioning

confidence: 87%

A case of myxedema coma caused by isolated thyrotropin stimulating hormone deficiency and Hashimoto's thyroiditis

et al. 2011

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Effects of bone mineral density of the lumbar spine and prevalent vertebral fractures on the risk of immobility

Abstract: These results indicate that low BMD and prevalent vertebral fracture pose an independent risk for future immobilization in postmenopausal Japanese women.

Cited by 28 publications

References 27 publications

Generation of Directly Converted Human Osteoblasts That Are Free of Exogenous Gene and Xenogenic Protein

Generation of Directly Converted Human Osteoblasts That Are Free of Exogenous Gene and Xenogenic Protein

Established Osteoporosis Associated with High Mortality after Adjustment for Age and Co-Mobidities in Postmenopausal Japanese Women

A case of myxedema coma caused by isolated thyrotropin stimulating hormone deficiency and Hashimoto's thyroiditis

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