Effects of borneol on the pharmacokinetics of 9-nitrocamptothecin encapsulated in PLGA nanoparticles with different size via oral administration

Abstract

Context: Although nanocarriers provide promising potential for oral drug delivery, the delivery efficiency remains unsatisfactory and needs to be improved. Size is considered to be the most important characteristic of nanoparticles related to their oral absorption. Borneol has been proved to have the ability to enhance the penetration and transport of many drugs through various physical barriers. Objective: To investigate the effect of the particle size and coadministration of borneol on the pharmacokinetics and bioavailability of entrapped drug in different size poly(lactic-co-glycolic acid) (PLGA) nanoparticles. Materials and methods: 9-Nitrocamptothecin (9-NC)-loaded PLGA nanoparticles with three different range of size (50-100 nm, 100-200 nm, 200-300 nm) were prepared by emulsion solvent-evaporation method. The pharmacokinetic study in rats of these nanoparticles with borneol was carried out. Results:The experiments showed that the encapsulation drug in nanoparticles with size below 200 nm could improve the oral bioavailability of 9-NC. The small size nanoparticles (50-100 nm) had a better improvement efficacy. As for borneol, it played a significant promotion effect only on the small nanoparticles. Moreover, there was no significant influence on the nanoparticles with size more than 100 nm. Discussion and conclusion: The study indicated that both entrapping drug in nanoparticles with the size below 100 nm and coadministrating with borneol could enhance the gastrointestinal absorption of water insoluble drug. The combination of the two strategies provides a potential approach to improve the oral bioavailability of drug.

Polydopamine and peptide decorated doxorubicin-loaded mesoporous silica nanoparticles as a targeted drug delivery system for bladder cancer therapy

“…The particle size and size distribution of NPs were detected by dynamic light scattering (DLS) ( Table 1 ). The surface properties and particle sizes of NPs crucially participate in drug release, cellular uptake together with biodistribution and pharmacokinetics in vivo (Wang et al, 2013 ; Ru et al, 2016 ). The particle sizes of DOX-loaded MSNs@PDA and DOX-loaded MSNs@PDA-PEP were 168.3 ± 8.1 and 170.2 ± 7.5, respectively, which were larger than that of MSNs because of PDA coating.…”

Borneol influences the pharmacokinetics of florfenicol through regulation of cytochrome P450 1A2 (CYP1A2), CYP2C11, CYP3A1, and multidrug resistance 1 (MDR1) mRNA expression levels in rats

“…However, Zou et al [38] reported that the T max and C max of berberine were significantly reduced after co-administration of borneol in rats [38]. Ru et al [27] reported that borneol could only promote the gastrointestinal absorption of small nanoparticles and had no effect on the absorption of drugs with a particle size greater than 100 nm. Lei et al [12] suggested that the effects of borneol on CYP3A4 and P-gp are significantly different and may be related to the optical rotation of borneol, as well as the dose of borneol and time of its administration.…”

<p>Multiple cargo deliveries of growth factors and antimicrobial peptide using biodegradable nanopolymer as a potential wound healing system</p>

“…37 PLGA NP has been used successfully as a growth factor delivery system due to its biocompatibility and degradability. 38,39 In the present paper, a drug delivery system using PLGA NP for the codelivery of growth factors and the AMP was developed. Dual growth factor-encapsulated NPs were prepared by modified solvent diffusion technique using poloxamer F127 as a stabilizer, which gave rise to NPs with a size of 416 nm.…”