Effects of Boron in Wound Healing

Dousset, B.; Benderdour, Mohamed; Heß, K.; Mayap-Nzietchueng, Rosine; Belleville, F.; Duprez, A

doi:10.1007/0-306-47466-2_325

Cited by 9 publications

(10 citation statements)

References 11 publications

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“…In our study, we provided evidence suggesting the immune priming effect of borax, a salt of boric acid, H 3 BO 3 , in BALB/c mice. Boron, which has been implicated in infection and immunity [ 9 , 11 , 35 – 36 ], is reported in this study to induce lymphocyte proliferation and increase the release of inflammatory mediators (cytokines and NO) by the peritoneal macrophages stimulated with LPS.…”

Section: Discussionmentioning

confidence: 95%

Boron Induces Lymphocyte Proliferation and Modulates the Priming Effects of Lipopolysaccharide on Macrophages

Routray

Ali

2016

PLoS ONE

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Chemical mediators of inflammation (CMI) are important in host defense against infection. The reduced capacity of host to induce the secretion of these mediators following infection is one of the factors in host susceptibility to infection. Boron, which has been suggested for its role in infection, is reported in this study to increase lymphocyte proliferation and the secretion of CMI by the lipopolysaccharide (LPS)-stimulated peritoneal macrophages in BALB/c mice. Boron was administered to mice orally as borax at different doses for 10 consecutive days, followed by the stimulation of animals with ovalbumin and isolation of splenocytes for proliferation assay. The lymphocyte subsets were determined by flow cytometry in spleen cell suspension. The mediators of inflammation, TNF-α, IL-6, IL-1β and nitric oxide (NO), were measured in culture supernatant of LPS-primed macrophages isolated from borax treated mice. TNF and ILs were measured by ELISA. NO was determined by Griess test. The expression of inducible nitric oxide synthase (iNOS) in macrophages was studied by confocal microscopy. Results showed a significant increase in T and B cell populations, as indicated by an increase in CD4 and CD19, but not CD8, cells. Boron further stimulated the secretion of TNF-α, IL-6, IL-1β, NO and the expression of iNOS by the LPS-primed macrophages. The effect was dose dependent and most significant at a dose level of 4.6 mg/kg b. wt. Taken together, the study concludes that boron at physiological concentration induces lymphocyte proliferation and increases the synthesis and secretion of pro-inflammatory mediators by the LPS-primed macrophages, more specifically the M1 macrophages, possibly acting through Toll-like receptor. The study implicates boron as a regulator of the immune and inflammatory reactions and macrophage polarization, thus playing an important role in augmenting host defense against infection, with possible role in cancer and other diseases.

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Section: Discussionmentioning

confidence: 95%

Boron Induces Lymphocyte Proliferation and Modulates the Priming Effects of Lipopolysaccharide on Macrophages

Routray

Ali

2016

PLoS ONE

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“…18 It has been suggested that boron may enhance wound healing and modulate inflammatory response. 19,20 Studies are needed to determine whether boron supplementation would be beneficial for humans recovering from traumatic injury.…”

Section: Boronmentioning

confidence: 99%

Trace Element Loss in Urine and Effluent Following Traumatic Injury

Klein

Nielsen

Moser-Veillon

2008

J Parenter Enteral Nutr

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“…Since they are composed of boron and nitrogen, they can be excellent needed as boron and nitrogen source in biosystems. Recently, it was demonstrated that BNs can be used as a boron source to promote wound healing and treat prostate cancer, and their degree of crystallinity is an important factor due to its influence on biodegradation (Dousset et al, 2002 ; Li et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

One-Step Synthesis of Hexagonal Boron Nitrides, Their Crystallinity and Biodegradation

Şen

Emanet

Çulha

2018

Front. Bioeng. Biotechnol.

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Hexagonal boron nitrides (hBNs) have recently been investigated for several novel applications due to their unique properties such as biocompatibility, superhydrophobicity, electrical insulation, and thermal and chemical stability. In addition, their biodegradation products have recently reported to have therapeutic effect on certain cancer types. hBNs are easily synthesized from boron and nitrogen precursors at moderately low temperatures. However, crystallinity and yield vary depending on the type of precursor, reaction temperature, and duration. In this study, a simple one-step hBNs synthesis method is reported without a catalyst, which might be an undesired contaminant for biomedical applications. The influence of boron precursors (boric acid, colemanite, or boron trioxide) on hBNs crystallinity, stability, and biodegradation in suspensions containing oxidative and hydrolytic degradation agents is investigated with the aim of their possible application in biomedicine. We found that the choice of boron precursor is a critically important parameter controlling the hBNs crystallinity and dependently influencing the biodegradation rate.

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Effects of Boron in Wound Healing

Cited by 9 publications

References 11 publications

Boron Induces Lymphocyte Proliferation and Modulates the Priming Effects of Lipopolysaccharide on Macrophages

Boron Induces Lymphocyte Proliferation and Modulates the Priming Effects of Lipopolysaccharide on Macrophages

Trace Element Loss in Urine and Effluent Following Traumatic Injury

One-Step Synthesis of Hexagonal Boron Nitrides, Their Crystallinity and Biodegradation

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