Effects of bosentan on neointimal response following coronary angioplasty

Sanmartı́n, Marcelo; Fernández‐Ortíz, Antonio; Fantidis, Panayotis; Aragoncillo, Paloma; Fernández‐Durango, Raquel; Rollín, R.; Alfonso, Fernándo; Hernández, Rosana; Escaned, Javier; Macaya, Carlos

doi:10.1046/j.1365-2362.2003.01217.x

Cited by 7 publications

(4 citation statements)

References 23 publications

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“…These studies indicate that activation of the ET-1/ET receptor system is involved in the development of vascular remodeling after vascular injury. Actually, a selective ET A receptor and ET A /ET B dual receptor antagonist show vasoprotective effects via inhibition of neointimal formation after balloon injury [9, 13–15]. In a clinical study, it was reported that ET-1 levels in the coronary circulation were increased after percutaneous transluminal coronary angioplasty (PTCA) [16].…”

Section: Vascular Et-1/et Receptor System In a Pathological Statementioning

confidence: 99%

“…In other words, antagonism of the ET A receptor is essential for the inhibition of neointimal formation after balloon injury, irrespective of the presence of ET B receptor-mediated actions. This hypothesis could explain why both selective ET A receptor and nonselective ET A /ET B dual receptor antagonists are equally effective in suppressing neointimal formation [9, 13–15]. …”

Section: Pathophysiological Roles Of the Etb Receptor In Vascular mentioning

confidence: 99%

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Pathological Importance of the Endothelin-1/ET_BReceptor System on Vascular Diseases

Kitada

Ohkita

Matsumura

2012

Cardiology Research and Practice

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Activation of the endothelin (ET)-1/ET receptor system is involved in the development of vascular diseases such as atherosclerosis, vascular hypertrophy, and restenosis. Some issues still remain unresolved including whether ET receptor antagonists are expected to become the new therapeutic tools for the treatment of vascular diseases. One of the unresolved critical points is the functional role of ET receptor subtypes on each vascular disease, in particular the pathophysiological roles of the ETB receptor. We recently demonstrated that selective inhibition of the ETB receptor system showed harmful effects in the development of neointimal formation after vascular injury. However, there was no apparent difference in the therapeutic effects between a nonselective ETA/ETB receptor antagonist and selective ETA receptor antagonist. These findings indicate that antagonism of the ETA receptor system is essential for suppressing vascular remodeling, irrespective of the presence of ETB-receptor-mediated actions, although the selective ETB receptor antagonist worsens vascular remodeling. In addition, we found that ET receptor systems contribute to sex differences in the severity of vascular disease, thereby suggesting that the efficacy of ET receptor antagonists for vascular diseases may differ between sexes. In this paper, we outline the roles of the ET-1/ETB receptor system on vascular diseases and its sex differences.

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Section: Vascular Et-1/et Receptor System In a Pathological Statementioning

confidence: 99%

Section: Pathophysiological Roles Of the Etb Receptor In Vascular mentioning

confidence: 99%

Pathological Importance of the Endothelin-1/ET_BReceptor System on Vascular Diseases

Kitada

Ohkita

Matsumura

2012

Cardiology Research and Practice

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“…ET B upregulation in SMC, mediating vasoconstriction and proliferation in cardiovascular disease,18,19 might explain studies reporting similar benefit from mixed ET A/B and selective ET A antagonism in reducing lesion formation23,39,40 (despite the protective roles of ET B in several tissues; e.g. EC, kidney).…”

Section: Discussionmentioning

confidence: 99%

Smooth Muscle Endothelin B Receptors Regulate Blood Pressure but Not Vascular Function or Neointimal Remodeling

et al. 2017

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“…An endothelin A/B receptor antagonist contributed to reduction of intimal hyperplasia in an organ culture of human saphenous veins and prevented neointimal development of coronary angioplasty in pigs, which is in accordance with our experiment. 23 , 24 αSMA is the specific protein of vascular smooth muscle cells and the expression of αSMA can reflect the hyperplasia of vascular smooth muscle cells. In our experiment, we examined the values of αSMA in grafted veins with RT-PCR and found that the values in the α-CA, RPM, and α-CA-RPM groups was lower than in the control group.…”

Section: Discussionmentioning

confidence: 99%

Rapamicina em Combinação com a-Cianoacrilato Contribui à Inibição de Hiperplasia Intimal em Modelos em Ratos

Tianshu-Chu¹,

Congrong-Gao²,

Zhiwei-zhao³

et al. 2018

Arquivos Brasileiros De Cardiologia

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BackgroundVein graft restenosis has an adverse impact on bridge vessel circulation and patient prognosis after coronary artery bypass grafting.ObjectivesWe used the extravascular supporter α-cyanoacrylate (α-CA), the local application rapamycin/sirolimus (RPM), and a combination of the two (α-CA-RPM) in rat models of autogenous vein graft to stimulate vein graft change. The aim of our study was to observe the effect of α-CA, RPM, and α-CA-RPM on vein hyperplasia.MethodsFifty healthy Sprague Dawley (SD) rats were randomized into the following 5 groups: sham, control, α-CA, RPM, and α-CA-RPM. Operating procedure as subsequently described was used to build models of grafted rat jugular vein on carotid artery on one side. The level of endothelin-1 (ET-1) was determined by enzyme-linked immunosorbent assay (ELISA). Grafted veins were observed via naked eye 4 weeks later; fresh veins were observed via microscope and image-processing software in hematoxylin-eosin (HE) staining and immunohistochemistry after having been fixed and stored” (i.e. First they were fixed and stored, and second they were observed); α-Smooth Muscle Actin (αSMA) and von Willebrand factor (vWF) were measured with reverse transcription-polymerase chain reaction (RT-PCR). Comparisons were made with single-factor analysis of variance and Fisher’s least significant difference test, with p < 0.05 considered significant.ResultsWe found that intimal thickness of the α-CA, RPM, and α-CA-RPM groups was lower than that of the control group (p < 0.01), and the thickness of the α-CA-RPM group was notably lower than that of the α-CA and RPM groups (p < 0.05).ConclusionRPM combined with α-CA contributes to inhibiting intimal hyperplasia in rat models and is more effective for vascular patency than individual use of either α-CA or RPM.

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Effects of bosentan on neointimal response following coronary angioplasty

Abstract: Oral treatment with bosentan reduces neointimal development following coronary angioplasty in this experimental model.

Cited by 7 publications

References 23 publications

Pathological Importance of the Endothelin-1/ET_BReceptor System on Vascular Diseases

Pathological Importance of the Endothelin-1/ET_BReceptor System on Vascular Diseases

Smooth Muscle Endothelin B Receptors Regulate Blood Pressure but Not Vascular Function or Neointimal Remodeling

Rapamicina em Combinação com a-Cianoacrilato Contribui à Inibição de Hiperplasia Intimal em Modelos em Ratos

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Effects of bosentan on neointimal response following coronary angioplasty

Abstract: Oral treatment with bosentan reduces neointimal development following coronary angioplasty in this experimental model.

Cited by 7 publications

References 23 publications

Pathological Importance of the Endothelin-1/ETBReceptor System on Vascular Diseases

Pathological Importance of the Endothelin-1/ETBReceptor System on Vascular Diseases

Smooth Muscle Endothelin B Receptors Regulate Blood Pressure but Not Vascular Function or Neointimal Remodeling

Rapamicina em Combinação com a-Cianoacrilato Contribui à Inibição de Hiperplasia Intimal em Modelos em Ratos

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Pathological Importance of the Endothelin-1/ET_BReceptor System on Vascular Diseases

Pathological Importance of the Endothelin-1/ET_BReceptor System on Vascular Diseases