Effects of botulinum toxin type A on the superior cervical ganglia in rabbits

Kim, Hyun Jeong; Seo, Kyle K.; Yum, Kwang Won; Oh, Yongseok; Yoon, Tae‐Jong; Yoon, Suk Min

doi:10.1016/s1566-0702(02)00093-0

Cited by 27 publications

(20 citation statements)

References 12 publications

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“…A reversible, transient analgesic effect is considered one of the advantages in the current case, and. in agreement with an experimental animal reports by Kim et al [18] in which BoNT-A caused no marked histopathologic changes as compared with cases in which blockage was done using alcohol or phenol, and the effects were persistently present for > 1 month.…”

Section: Discussionsupporting

confidence: 92%

Ganglion Impar Block With Botulinum Toxin Type A for Chronic Perineal Pain -A Case Report-

et al. 2010

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Chronic perineal pain is an often encountered problem, which produces a great degree of functional impairment and frustration to the patient and a challenge to the treating physician. The reason for this problem is that the region contains diverse anatomic structures with mixed somatic, visceral and autonomic innervations affecting bladder and bowel control and sexual function. A blockade of nociceptive and sympathetic supply to the perineal region, supplied through the ganglion impar has been shown to benefit patients with chronic perineal pain. Several options to this block have been described that chemical neurolysis, radiofrequency ablation etc. Although the analgesic effect of Botulinum toxin type A (BoNT-A) has long been considered secondary to its action for muscle relaxation, BoNT-A also affects the release of the neurotransmitters that are involved in pain perception. We describe a patient who was successfully given ganglion impar block with BoNT-A.

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Section: Discussionsupporting

confidence: 92%

Ganglion Impar Block With Botulinum Toxin Type A for Chronic Perineal Pain -A Case Report-

et al. 2010

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“…The effects of BTA lasted several months to a year [5,6]. BTA prevents the release of acetylcholine from cholinergic nerve terminals; preganglionic sympathetic nerves are cholinergic, and Kim and colleagues [7] reported that BTA can induce prolonged sympathetic blockade of the superior cervical ganglia in rabbits.…”

Section: Introductionmentioning

confidence: 99%

Prediction of compensatory hyperhidrosis with botulinum toxin A and local anesthetic

et al. 2015

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“…Der Einsatz des Subtyps BTX-B ist möglicher-weise gerade besonders sinnvoll, da die Substanz zusätzlich bevorzugt an autonomen Nerven wirkt und autonome Effekte ausgeprägter sind als bei Behandlung mit BTX-A [29,30]. In Tierversuchen wirkte BTX am Ganglion cervicale superius und wurde als mögliche Behandlungsoption bei sympathisch unterhaltenen Schmerzen diskutiert [58]. Auch die Tatsache, dass präganglionär-sympathische Neurone cholinerg sind, führte zur Spekulation, dass eine anhaltende, sympathische Denervation durch BTX möglich sei [1].…”

Section: Wirkungen Am Sympathischen Nervensystemunclassified