Effects of bovine colostrum supplementation on upper respiratory illness in active males

Jones, Arwel W.; Cameron, Simon; Thatcher, Rhys; Beecroft, Marikka S.; Mur, Luis A. J.; Davison, Glen

doi:10.1016/j.bbi.2013.10.032

Cited by 40 publications

(110 citation statements)

References 53 publications

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“…Although there was no effect on the summed response, there were clear differences at the lowest dose and increased sensitivity in the COL group. Taken together this supports previous evidence from our laboratory where COL has been shown to act as a nutritional countermeasure to the decreased immunity (and increased susceptibility to illness) following prolonged exercise( 1,2) .…”

Section: Resultssupporting

confidence: 79%

Bovine colostrum supplementation enhances sensitivity of the in vivo immune response to a novel antigen following prolonged exercise

Davison¹,

al²

2018

Arspa

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A navegação consulta e descarregamento dos títulos inseridos nas Bibliotecas Digitais UC Digitalis, UC Pombalina e UC Impactum, pressupõem a aceitação plena e sem reservas dos Termos e Condições de Uso destas Bibliotecas Digitais, disponíveis em https://digitalis.uc.pt/pt-pt/termos.Conforme exposto nos referidos Termos e Condições de Uso, o descarregamento de títulos de acesso restrito requer uma licença válida de autorização devendo o utilizador aceder ao(s) documento(s) a partir de um endereço de IP da instituição detentora da supramencionada licença.Ao utilizador é apenas permitido o descarregamento para uso pessoal, pelo que o emprego do(s) título(s) descarregado(s) para outro fim, designadamente comercial, carece de autorização do respetivo autor ou editor da obra. Na medida em que todas as obras da UC Digitalis se encontram protegidas pelo Código do Direito de Autor e Direitos Conexos e demais legislação aplicável, toda a cópia, parcial ou total, deste documento, nos casos em que é legalmente admitida, deverá conter ou fazer-se acompanhar por este aviso.Bovine colostrum supplementation enhances sensitivity of the in vivo immune response to a novel antigen following prolonged exercise Autor(es):

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Section: Resultssupporting

confidence: 79%

Bovine colostrum supplementation enhances sensitivity of the in vivo immune response to a novel antigen following prolonged exercise

Davison¹,

al²

2018

Arspa

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“…However, we have undertaken a number of studies on various immune markers and, on average, have observed a large effect (Cohen's d = 1.25) with the dosage of bovine colostrum used in the present study (e.g., [18,19,26]). To detect such a magnitude of effect in this study, a sample size of n = 15 per group (n = 30 in total) is required to provide > 90% power.…”

Section: Discussionmentioning

confidence: 99%

“…The previous findings of no inhibitory effect of prolonged exercise on skinfold responses to the irritant, croton oil, provide evidence that in the context of DPCP, responses are dependent on cell-mediated events rather than local inflammatory processes [15]. Given that a recent meta-analysis [16] of five randomised controlled trials (including one from our laboratory) of COL supplementation showed a reduction in the incidence of URS during exercise training [26,[32][33][34], it is likely that an increase in recall sensitivity provides a mechanistic explanation for reduced URS. It will be useful, however, for future studies to monitor URS in the period following DPCP sensitisation.…”

Section: Discussionmentioning

confidence: 99%

“…Although investigations on whole blood maintains the proximity of leukocytes and the extracellular milieu of leukocytes compared to other in vitro measures of immune function, the use of in vivo measures is considered more clinically relevant [7,11,22]. We previously demonstrated that COL limits the increased salivary bacterial load in physically active males during the winter months [26], and proposed this to be a relevant marker of in vivo (innate) immunity that needed further testing in an exercise immunology context. Here, we have used a controllable, reproducible, and valid marker of exercise-induced immunity in vivo.…”

Section: Discussionmentioning

confidence: 99%

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The effects of bovine colostrum supplementation on in vivo immunity following prolonged exercise: a randomised controlled trial

et al. 2017

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Background Bovine colostrum (COL) has been advocated as a nutritional countermeasure to exercise-induced immune dysfunction, but there is a lack of research with clinically relevant in vivo measures. Aim To investigate the effects of COL supplementation on in vivo immunity following prolonged exercise using experimental contact hypersensitivity (CHS) with the novel antigen diphenylcyclopropenone (DPCP). Methods In a double-blind design, 31 men were randomly assigned to COL (20 g/day) or placebo (PLA) for 58 days. Participants ran for 2 h at 60% maximal aerobic capacity on day 28 and received a primary DPCP exposure (sensitisation) 20 min after. On day 56, participants received a low-dose-series DPCP challenge to elicit recall of in vivo immune-specific memory (quantified by skinfold thickness 24 and 48 h later). Analysis of the dose-response curves allowed determination of the minimum dose required to elicit a positive response (i.e., sensitivity). Results There was no difference in summed skinfold thickness responses between COL and PLA at 24 h (p = 0.124) and 48 h (p = 0.405). However, sensitivity of in vivo immune responsiveness was greater with COL at 24 h (p < 0.001) and 48 h (p = 0.023) with doses ~ twofold greater required to elicit a positive response in PLA. Conclusions COL blunts the prolonged exercise-induced decrease in clinically relevant in vivo immune responsiveness to a novel antigen, which may be a mechanism for reduced illness reports observed in the previous studies. These findings also suggest that CHS sensitivity is highly relevant to host defence.

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“…Regular ingestion of bovine colostrum may also limit the increase in gut permeability caused by prolonged strenuous exercise and reduce the risk of developing heat stroke 50 . Several studies have also reported that daily oral bovine colostrum supplementation reduces the total number of days with self-reported URS 48,[51][52][53] , the incidence of URS episodes 48,[51][52][53][54] and duration of self-reported URS episodes 51,53 in adults involved in exercise training.…”

Section: Colostrummentioning

confidence: 99%

Immunological aspects of sport nutrition

Gleeson

2015

Immunol Cell Biol

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Prolonged bouts of exercise and heavy training regimens are associated with depression of immune system functions which can increase the risk of picking up opportunistic infections such as the common cold and influenza. Some common sport nutrition practices including high carbohydrate diets and carbohydrate ingestion during exercise, training with low glycogen stores, intentional dieting for weight loss, ingestion of high dose antioxidant supplements and protein ingestion post-exercise may influence immune system status in athletes. In order to maintain robust immunity, athletes need to consume a well-balanced diet that is sufficient to meet their requirements for energy, carbohydrate, protein, and micronutrients. Dietary deficiencies of protein and specific micronutrients are well known to be potential causes of immune dysfunction and an adequate intake of some essential minerals including iron and zinc and the vitamins A, D, E, B6 and B12 are important to maintain a healthy immune function. Vitamin D may be a particular concern as recent studies have emphasised its importance in limiting infection episode incidence and duration in both the general population and in athletes and many individuals exhibit inadequate vitamin D status during the winter months. There is only limited evidence that individual amino acids, -glucans, herbal extracts and zinc are capable of boosting immunity or reducing infection risk in athletes. The ingestion of carbohydrate during exercise and daily consumption of probiotics, vitamin D3, bovine colostrum, and plant polyphenol containing supplements or foodstuffs currently offer the best chance of success, particularly for those individuals who are prone to illness.

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Effects of bovine colostrum supplementation on upper respiratory illness in active males

Cited by 40 publications

References 53 publications

Bovine colostrum supplementation enhances sensitivity of the in vivo immune response to a novel antigen following prolonged exercise

Bovine colostrum supplementation enhances sensitivity of the in vivo immune response to a novel antigen following prolonged exercise

The effects of bovine colostrum supplementation on in vivo immunity following prolonged exercise: a randomised controlled trial

Immunological aspects of sport nutrition

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