Effects of Bovine Growth Hormone, Human Placental Lactogen and Ovine Prolactin on Intestinal Fluid and Ion Transport in the Rat

Mainoya, J. R.

doi:10.1210/endo-96-5-1165

Cited by 90 publications

(27 citation statements)

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“…The first observation confirms and extends the previously reported proabsorptive effect of animal GH (8,19) to recombinant DNA-derived human GH. Furthermore, this work first shows that the effect on intestinal transport has a rapid onset, being observed within minutes from a single i.v.…”

Section: """"------------------------- --------supporting

confidence: 87%

“…The in vitro effect was longer than that seen in vivo, which can be explained by the intervention of homeostatic mechanisms to balance an excessive fluid retention in the in vivo rat. The dose response represents the first evidence of such a feature of the effect of GH on fluid retention , because a clear dose response was not obtained in previous work describing the influence of animal GH on intestinal transport (19).…”

mentioning

confidence: 86%

“…Half-maximal effect was achieved with 10-6 M (n = 5 for each data point). 4x1O-6 6x10 -6 8x10-6 r-hGH con centration (M) 5x1O-7 10 -7 It has been previously reported that hypophysectomy causes a decrease in water and electrolyte absorption in the rat jejunum and this can be prevented by pretreatment with bovine GH (19) . An intestinal proabsorptive effect has been previously reported in normal rats, receiving ovine GH by s.c. route (8) .…”

Section: Lack Ofreversibility Ofr-hgh Effectmentioning

confidence: 99%

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In Vivo and In Vitro Effects of Human Growth Hormone on Rat Intestinal Ion Transport

et al. 1995

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It has been reported that: I ) ovine growth hormone stimulates intestinal water, sodium, and chloride absorption and 2) specific growth hormone receptors are present in the rat intestine. Aims of this work were to investigate the effects of acute administration of hGH on water and ion transport in the rat ileum in vivo and in vitro. In vivo, the absorption rates of water, sodium, chloride, and potassium were determined in the rat perfused ileum, during a basal period and after i.v. administration of 6 Mg/kg recombinant DNA-derived hGH. In vitro , electrical parameters were measured before and after the hormone addition to the mucosal or the serosal side of rat ileal mucosa mounted in Ussing chambers. In vivo, growth hormone induced a rapid increase in the absorption rates of water, sodium, chloride, and potassium. In vitro, the serosal, but not the mucosal, addition of growth hormone induced a rapid decrease of transepithelial potential difference and of short-circuit current. The effect was time-and dose-dependent, saturable, but not reversible in the short time. The electrical'effect was abolished in the absence of The ability of GH to induce fluid retenti on is well established , but the mechanisms of this effect are not well und erstood (1). Most studies have focused on the interr elationships between various hormones taking part to the complex network that regulates Na + balance and on the renal effects of GH (1).It is now known that the intestine plays an important role in the regulation of body fluid home ostasis (2). GH has several effects at the intestinal level. In fact, it stimulates intestinal growth and differentiation (3, 4), vitamin D-dep endent Ca 2 + binding protein synthesis (5), and Ca 2 + absorption (6). Furthermore, GH increases the gastrin and somatostatin contents of rat stom ach ,(7). Finally, it has been previousl y shown that high doses of ovine GH, given to rats for 2 d in vivo, incre ased the absorption rates of H 2 0 and electrolytes as measured by intestinal everted sacs (8). chloride, indicating that it was related, at least in part, to inhibition of basal active chloride secretion. Growth hormone also reduced the short-circuit current increase induced by the secretagogues Escher ichia coli heat-stable enterotoxin, theophylline, and calcium ionophore A23187. These results indicate that hGH has a rapid absorptive effect that is related, at least in part, to a direct intestinal antisecretory mechanism. It also reduces active intestinal secretion induced by various secretagogues. (Pediatr Res 37: 576-580, 1995) Abbreviations GH , growth hormone r·hGH, recombinant DNA-derived hGH Isc, short-circuit current PD, transepithelial potential difference G, tissue conductance ST, Escherichia coli heat-stable enterotoxin tionally believed to be mediat ed by GH-dep endent production of mediators such as IGF-I (9, 10). Howe ver, it has been report ed that IGF-I does not cause fluid retention (11). Recently GH has been shown to inhibit the production of the atrial natriuretic peptid e (12) . I...

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confidence: 87%

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confidence: 86%

Section: Lack Ofreversibility Ofr-hgh Effectmentioning

confidence: 99%

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In Vivo and In Vitro Effects of Human Growth Hormone on Rat Intestinal Ion Transport

et al. 1995

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“…Prolactin's effect to increase intestinal calcium absorption was confirmed in pregnant, severely vitamin D-deficient rats (690). An effect of prolactin and placental lactogen was also observed in everted gut sacs of nonpregnant, hypophysectomized rats, which thereby removed the confounding effects of prolactin release from the pituitary (586,894). Estradiol also has effects independent of calcitriol to stimulate intestinal calcium absorption and expression of TRPV6 and TRPV5 (192,949).…”

Section: Animal Datamentioning

confidence: 88%

“…Vdr null mice show downregulation of intestinal TRPV6 when nonpregnant but a marked upregulation during pregnancy while on a calcium-enriched "rescue diet" (296,949), whereas upregulation in calbindin-D9k was found during pregnancy on a normal-calcium diet (786). Prolactin, placental lactogen, and growth hormone have been shown to stimulate intestinal calcium absorption independently of calcitriol, possibly through actions to increase expression of TRPV6, TRPV5, calbindin-D9k, and PMCA1 (12,171,586,690,894,901). As noted above, growth hormone is normally suppressed during pregnancy, but placental growth hormone is increased and may stimulate intestinal calcium absorption.…”

Section: Animal Datamentioning

confidence: 99%

Maternal Mineral and Bone Metabolism During Pregnancy, Lactation, and Post-Weaning Recovery

Kovacs

2016

Physiological Reviews

384

524

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During pregnancy and lactation, female physiology adapts to meet the added nutritional demands of fetuses and neonates. An average full-term fetus contains ϳ30 g calcium, 20 g phosphorus, and 0.8 g magnesium. About 80% of mineral is accreted during the third trimester; calcium transfers at 300-350 mg/day during the final 6 wk. The neonate requires 200 mg calcium daily from milk during the first 6 mo, and 120 mg calcium from milk during the second 6 mo (additional calcium comes from solid foods). Calcium transfers can be more than double and triple these values, respectively, in women who nurse twins and triplets. About 25% of dietary calcium is normally absorbed in healthy adults. Average maternal calcium intakes in American and Canadian women are insufficient to meet the fetal and neonatal calcium requirements if normal efficiency of intestinal calcium absorption is relied upon. However, several adaptations are invoked to meet the fetal and neonatal demands for mineral without requiring increased intakes by the mother. During pregnancy the efficiency of intestinal calcium absorption doubles, whereas during lactation the maternal skeleton is resorbed to provide calcium for milk. This review addresses our current knowledge regarding maternal adaptations in mineral and skeletal homeostasis that occur during pregnancy, lactation, and post-weaning recovery. Also considered are the impacts that these adaptations have on biochemical and hormonal parameters of mineral homeostasis, the consequences for long-term skeletal health, and the presentation and management of disorders of mineral and bone metabolism.

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Pregnancy and Lactation

Kovacs¹,

Kronenberg²

2013

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism

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Effects of Bovine Growth Hormone, Human Placental Lactogen and Ovine Prolactin on Intestinal Fluid and Ion Transport in the Rat

Cited by 90 publications

References 0 publications

In Vivo and In Vitro Effects of Human Growth Hormone on Rat Intestinal Ion Transport

In Vivo and In Vitro Effects of Human Growth Hormone on Rat Intestinal Ion Transport

Maternal Mineral and Bone Metabolism During Pregnancy, Lactation, and Post-Weaning Recovery

Pregnancy and Lactation

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