Effects of BPF on steroid hormone homeostasis and gene expression in the hypothalamic–pituitary–gonadal axis of zebrafish

Yang, Qian; Yang, Xianhai; Liu, Jining; Ren, Wenjuan; Chen, Yingwen; Shen, Shubao

doi:10.1007/s11356-017-9773-z

Cited by 61 publications

(32 citation statements)

References 48 publications

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“…For example, expression of reproductive/neuroendocrine related genes such as kiss1 , kiss1r , gnrh3 and lhbeta was significantly increased at both 24 hpf and 120 hpf upon low level (0.045–0.45 μmol L ‐1 ) BPA or BPS exposure 46 . Additional work investigating gene expression patterns in juvenile and/or adult animals in the hypothalamic region and/or the hypothalamic‐pituitary‐gonadal axis confirmed an effect of bisphenols in adult fish 46,95,96 and juvenile rodent 97 …”

Section: Discussionmentioning

confidence: 82%

Impacts of bisphenol A analogues on zebrafish post‐embryonic brain

Coumailleau

Trempont

Pellegrini

et al. 2020

J Neuroendocrinology

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Bisphenol A (BPA) is a widely studied and well‐recognised endocrine‐disrupting chemical, and one of the current issues is its safe replacement by various analogues. Using larva zebrafish as a model, the present study reveals that moderate and chronic exposure to BPA analogues such as bisphenol S, bisphenol F and bisphenol AF may also affect vertebrate neurodevelopment and locomotor activity. Several parameters of embryo‐larval development were investigated, such as mortality, hatching, number of mitotically active cell, as defined by 5‐bromo‐2'‐deoxyuridine incorporation and proliferative cell nuclear antigen labelling, aromatase B protein expression in radial glial cell and locomotor activity. Our results show that exposure to several bisphenol analogues induced an acceleration of embryo hatching rate. At the level of the developing brain, a strong up‐regulation of the oestrogen‐sensitive Aromatase B was also detected in the hypothalamic region. This up‐regulation was not associated with effects on the numbers of mitotically active progenitors nor differentiated neurones in the preoptic area and in the nuclear recessus posterior of the hypothalamus zebrafish larvae. Furthermore, using a high‐throughput video tracking system to monitor locomotor activity in zebrafish larvae, we show that some bisphenol analogues, such as bisphenol AF, significantly reduced locomotor activity following 6 days of exposure. Taken together, our study provides evidence that BPA analogues can also affect the neurobehavioural development of zebrafish.

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Section: Discussionmentioning

confidence: 82%

Impacts of bisphenol A analogues on zebrafish post‐embryonic brain

Coumailleau

Trempont

Pellegrini

et al. 2020

J Neuroendocrinology

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“…A previous study suggested that BPA might act as an estrogenic agonist in males who have low endogenous estrogen levels, and conversely act as an antagonist in females who have higher endogenous estrogen levels [36]. Sex differences in estrogenic activity were also observed for BPF in an animal study [25]. Further investigation is warranted to clarify the health effects of BPA and BPF for each sex.…”

Section: Discussionmentioning

confidence: 97%

“…BPF was also found to interfere with hormonal regulation by deregulating messenger RNA/long non-coding RNA and micro RNA in a human primary adipocyte model [24]. Moreover, BPF exhibited adverse effects on the hypothalamic-pituitary-gonadal axis, which is crucial for energy storage and consumption [2526]. Second, BPF could promote differentiation of preadipocytes and increase lipid accumulation by affecting the peroxisome proliferator-activated receptor gamma signaling pathway [1227].…”

Section: Discussionmentioning

confidence: 99%

Association of Bisphenol A and Its Substitutes, Bisphenol F and Bisphenol S, with Obesity in United States Children and Adolescents

et al. 2019

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Background Bisphenol F (BPF) and bisphenol S (BPS) are increasingly used as substitutes for bisphenol A (BPA), an environmental obesogen. However, health effects of BPF and BPS remain unclear. In this study, we evaluated the associations of BPA, BPF, and BPS with obesity in children and adolescents. Methods We used data from the U.S. National Health and Nutrition Examination Survey 2013 to 2014, a nationally representative study. We included 745 participants aged 6 to 17 years old. General obesity was defined based on the 2000 Centers for Disease Control and Prevention body mass index-for-age growth charts for the United States. Abdominal obesity was defined as waist-to-height ratio ≥0.5. Results After adjustment for demographic, socioeconomic and lifestyle factors, and urinary creatinine levels, the odds ratio of general obesity comparing the highest with lowest quartile of urinary bisphenol levels was 1.74 (95% confidence interval [CI], 0.92 to 3.31) for BPA, 1.54 (95% CI, 1.02 to 2.32) for BPF, and 1.36 (95% CI, 0.53 to 3.51) for BPS. Moreover, the associations were stronger in boys than in girls for BPA and BPF. Similar results were observed for abdominal obesity. Conclusion This study for the first time showed that exposure to BPF, a commonly used substitute for BPA, was positively associated with higher risk of obesity in children and adolescents. The association of BPA and BPF with general and abdominal obesity was primarily observed in boys, suggesting a possible sex difference. Further investigations on the underlying mechanisms are needed.

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“…Considering the structural similarity to BPA, the analogs (BPS, BPF, BPAF) may have similar endocrine-disrupting effects to those of BPA (23, 27, 28). Studies in zebrafish have reported the disrupting effects on steroid hormones of BPS (29), BPF (30), and BPAF (31). However, the potential harmful effects on glucose homeostasis of these BPA substitutes, which were used more and more widely and frequently in our daily life, are still unknown.…”

Section: Introductionmentioning

confidence: 99%

Exposure to Bisphenol a Substitutes and Gestational Diabetes Mellitus: A Prospective Cohort Study in China

et al. 2019

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Background: The association of bisphenol A (BPA) and gestational diabetes mellitus (GDM) has been investigated in only a small number of studies, and research on the associations between BPA substitutes and GDM is scarce. Objective: We aimed to investigate the associations of four bisphenols [bisphenol A (BPA), bisphenol S (BPS), bisphenol F (BPF), and bisphenol AF (BPAF)] levels in urine sample with the risk of gestational diabetes mellitus (GDM) and plasma glucose levels. Methods: A total of 1,841 pregnant women from a cohort study were recruited at their first prenatal examination between 2013 and 2015 in Wuhan, China. Concentrations of four bisphenols (BPA, BPS, BPF, BPAF) were measured in first-trimester urine samples using Ultra-high performance liquid chromatography system coupled to a Triple Quadrupole mass spectrometer (UHPLC-TQMS). An oral glucose tolerance test (OGTT) was performed at 24–28 gestational weeks and GDM was diagnosed post hoc using International Association of Diabetes and Pregnancy Study Groups criteria. We used multivariable logistic regression models to examine the associations of urinary bisphenols with the risk of GDM, and multiple linear regression models to determine the associations between bisphenols exposure and plasma glucose levels. Results: Urinary BPAF was associated with increased odds of GDM among women with normal pre-pregnancy BMI [adjusted odds ratio (aOR) = 1.70 (95% CI: 1.08, 2.67) for the highest group compared to the lowest group], and the association remained significant after additional adjustment for other bisphenols [aOR = 1.68 (95% CI: 1.03, 2.72)]. No significant associations were observed for other bisphenols and GDM. Consistent with the result of GDM, women in the highest BPAF category had a mean of 0.05 mmol/L (95% CI: 0.01, 0.09) higher fasting plasma glucose (FPG) levels than women in the lowest category. For BPA and plasma glucose, non-linear associations were observed between urinary BPA and FPG and the sum of the PG z -score among women who were overweight ( p for non-linear association < 0.05). We also found that the per-unit increase in natural log transformed specific gravity adjusted BPS [ln (SG-adj BPS)] was associated with a 0.03 mmol/L (95% CI: 0.01, 0.04) increase in FPG levels and the associations might be modified by fetal sex ( p for interaction < 0.05). Among women with female fetus, a per-unit increase in ln (SG-adj BPS) was associated with a 0.04 mmol/L (95% CI: 0.02, 0.06) increase in FPG, a 0.11 mmol/L (95% CI: 0.04, 0.17) increase in 1 h-PG and a 0.19 mmol/L (95% CI: 0.08, 0.30) increase in the sum of PG z -score. Conclusions: Our results provide evidence that BPAF and BPS might be potential risk factors of GDM, which require to be studied further.

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Effects of BPF on steroid hormone homeostasis and gene expression in the hypothalamic–pituitary–gonadal axis of zebrafish

Cited by 61 publications

References 48 publications

Impacts of bisphenol A analogues on zebrafish post‐embryonic brain

Impacts of bisphenol A analogues on zebrafish post‐embryonic brain

Association of Bisphenol A and Its Substitutes, Bisphenol F and Bisphenol S, with Obesity in United States Children and Adolescents

Exposure to Bisphenol a Substitutes and Gestational Diabetes Mellitus: A Prospective Cohort Study in China

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