Effects of branched-chain amino acid supplementation after radiofrequency ablation for hepatocellular carcinoma: A randomized trial

Nojiri, Shunsuke; Fujiwara, Kei; Shinkai, Noboru; Iio, Etsuko; Joh, Takashi

doi:10.1016/j.nut.2016.07.013

Cited by 41 publications

(63 citation statements)

References 44 publications

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“…While BCAA catabolism is upregulated in glioblastoma and NSCLC, leukemia displays increased reverse reaction and generates BCAAs from branchedchain ketoacids (BCKAs) 161 , which supports the disease progression 164 . In liver cancer, BCAA supplementation has been shown to improve patient prognosis [165][166][167] . Understanding how the tissue-of-origin and surrounding environment interact and influence metabolic requirements in cancer will be critical to selecting the appropriate therapeutic regimens for patients.…”

Section: Therapeutic Applications From Amino Acid Metabolismmentioning

confidence: 99%

Amino acids in cancer

et al. 2020

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Over 90 years ago, Otto Warburg's seminal discovery of aerobic glycolysis established metabolic reprogramming as one of the first distinguishing characteristics of cancer 1. The field of cancer metabolism subsequently revealed additional metabolic alterations in cancer by focusing on central carbon metabolism, including the citric acid cycle and pentose phosphate pathway. Recent reports have, however, uncovered substantial non-carbon metabolism contributions to cancer cell viability and growth. Amino acids, nutrients vital to the survival of all cell types, experience reprogrammed metabolism in cancer. This review outlines the diverse roles of amino acids within the tumor and in the tumor microenvironment. Beyond their role in biosynthesis, they serve as energy sources and help maintain redox balance. In addition, amino acid derivatives contribute to epigenetic regulation and immune responses linked to tumorigenesis and metastasis. Furthermore, in discussing the transporters and transaminases that mediate amino acid uptake and synthesis, we identify potential metabolic liabilities as targets for therapeutic intervention.

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Section: Therapeutic Applications From Amino Acid Metabolismmentioning

confidence: 99%

Amino acids in cancer

et al. 2020

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“…Most of the LES were administered between 09:00 pm and 10:00 pm . As displayed in Table , the duration of LES administration was two consecutive weeks in one study, five consecutive weeks in one study, 3 months in two studies, and 12 months in four studies …”

Section: Resultsmentioning

confidence: 99%

“…The most sensitive and representative indicator of recent changes in liver function was PT . Among the six studies that discussed PT, only that of Harima et al . was a short‐term study, which involved 5 weeks of LES administration.…”

Section: Discussionmentioning

confidence: 99%

“…The most sensitive and representative indicator of recent changes in liver function was PT. 24 Among the six studies that discussed PT, 7,14,15,[19][20][21] only that of Harima et al 14 was a short-term study, which involved 5 weeks of LES administration. The effect size of this study was À0.019 (95% CI [À0.843, À0.806], P = 0.965), which was closest to zero of all these six studies, suggesting that short-term LES administration did not improve liver function.…”

Section: Discussionmentioning

confidence: 99%

“…As displayed in Table 2, the duration of LES administration was two consecutive weeks in one study, 18 five consecutive weeks in one study, 14 3 months in two studies, 8,19 and 12 months in four studies. 7,15,20,21 Composition and dosage of the late evening snack. As listed in Table 2, only five studies have examined the effects of LES with branched-chain amino acid (BCAA) nutrients on patients with LC and HCC; the total calories provided in LES were 200-210 kcal in most studies; only one study provided up to 320 kcal.…”

Section: Late Evening Snack Administrationmentioning

confidence: 99%

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Significant effects of late evening snack on liver functions in patients with liver cirrhosis: A meta‐analysis of randomized controlled trials

Chen

Wang

Kuo

et al. 2019

J of Gastro and Hepatol

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Background and Aim Reducing post‐absorptive (fasting) phase by eating late evening snacks (LESs) is a potential intervention to improve substrate utilization and reverse sarcopenia. This study analyzed the results of published randomized controlled trials and controlled clinical trials to evaluate the effects of LES on liver function of patients with cirrhosis. Methods A meta‐analysis was conducted. The search strategy included electronic database searches, and 300 articles were searched. Eight of these articles provided qualified data for pooling and analysis. Outcomes assessments included serum albumin, total bilirubin, alanine aminotransferase, prothrombin time, and aspartate aminotransferase, complications of cirrhosis, severity of liver disease, and blood glucose levels. Results Our analysis included eight studies comprising 341 patients (167 in LES groups and 174 in control groups). The results showed that LES intervention helped to maintain liver reserves. These eight studies demonstrated that LES intervention had significant effects for liver biochemical parameters on albumin, ammonia, and prothrombin time, with respective effect sizes of 0.233, −0.425, and −0.589; liver enzymes include aspartate aminotransferase and alanine aminotransferase, with respective effect sizes of −0.320 and −0.284. Studies on clinical signs of liver dysfunction showed lower occurrence rates of ascites and hepatic encephalopathy than in the control group. LES had no significant effect on Child–Pugh score. Conclusions The overall results of the meta‐analysis indicated that having LES can improve liver function reserve for patients with liver cirrhosis, with or without hepatocellular carcinoma. LES is a promising intervention for reversing anabolic resistance and the sarcopenia of cirrhosis, resulting in an improved quality of life for patients with cirrhosis.

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