Effects of brazilin on blood viscosity and erythrocyte deformability in alloxan induced diabetic rats

Brazilin, the main constituent of Caesalpinia sappan, is an antioxidative substance that has catechol moiety in its chemical structure. Considering the antioxidant-activity of brazilin, it was expected to have protective effects on the toxicities of radical generating chemicals. The incubation of rat hepatocytes with BrCCl3 resulted in significant increase in lipid peroxidation, leakage of cytoplasmic enzymes and cytoplasmic glutathione depletion. The BrCCl3-induced toxicities on hepatocytes were reduced by the treatment of brazilin. Brazilin has been also proved to have a protective effect on the BrCCl3-induced depression of microsomal calcium sequestration activity. These results indicate that brazilin plays a protective role in BrCCl3-induced hepatocyte injury of the rat.

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Effects of brazilin on blood viscosity and erythrocyte deformability in alloxan induced diabetic rats

Cited by 3 publications

References 7 publications

Effects of brazilin on glucose metabolism in primary cultured rat hepatocytes

Effects of brazilin on glucose metabolism in primary cultured rat hepatocytes

Effects of brazilin on glucose oxidation, lipogenesis and therein involved enzymes in adipose tissues from diabetic KK-mice

BRAZILIN PROTECTS CULTURED RAT HEPATOCYTES FROM BrCCI₃-INDUCED TOXICITY

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Effects of brazilin on blood viscosity and erythrocyte deformability in alloxan induced diabetic rats

Cited by 3 publications

References 7 publications

Effects of brazilin on glucose metabolism in primary cultured rat hepatocytes

Effects of brazilin on glucose metabolism in primary cultured rat hepatocytes

Effects of brazilin on glucose oxidation, lipogenesis and therein involved enzymes in adipose tissues from diabetic KK-mice

BRAZILIN PROTECTS CULTURED RAT HEPATOCYTES FROM BrCCI3-INDUCED TOXICITY

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Product

Resources

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BRAZILIN PROTECTS CULTURED RAT HEPATOCYTES FROM BrCCI₃-INDUCED TOXICITY