Effects of brazilin on glucose metabolism in isolated soleus muscles from streptozotocin induced diabetic rats

In vitro anti-diabetic effect of flavonoids and pheophytins from Allophylus cominia Sw . on the glucose uptake assays by HepG2, L6, 3T3-L1 and fat accumulation in 3T3-L1 adipocytes

“…Flavonoids seemed to work differently than TNF-α. It has been reported (Moon et al, 1990;Lee et al, 1994;Khil et al, 1999) that the hypo-glycaemic action of compounds may be due to the stimulation of glucose transport and metabolism in insulin target organs, such as 3T3-L1 adipocytes. The translocation of GLUT4 transporters is mediated by the fusion of the plasma membrane and vesicles containing GLUT4 proteins, in which the intracellular calcium causes conformational changes in the membrane compartment to facilitate the translocation process (Muller et al, 2014).…”

“…Troglitazone has been used in studies for enhancing adipocyte differentiation in vitro (Khil et al, 1999). It has been suggested that the decrease in lipid accumulation in 3T3-L1 cells may be associated with the expression of GLUT4 transporters translocation in the cell membrane (Moon et al, 1990).…”

Effects of brazilin on the production of fructose-2,6-bisphosphate in rat hepatocytes

“…In addition, we reported that brazilin exhibited hypoglycemic effects in streptozotocin-induced diabetic rats and KK-mice without any changes in plasma insulin levels. The effects are primarily caused by improving peripheral glucose metabolism, including glucose transport, glycogen synthesis and insulin binding in adipose tissues, liver and muscle (Moon et al, 1990(Moon et al, , 1993. We also found that brazilin decreases gluconeogenesis in normal and diabetic hepatocytes (Won et al, 2004).…”