Effects of Breast-Conserving Therapy on Lactation After Pregnancy

Moran, Meena S.; Colasanto, Joseph M.; Haffty, Bruce G.; Wilson, Lynn D.; Lund, M; Higgins, Susan A.

doi:10.1097/00130404-200509000-00007

Cited by 56 publications

(31 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…21 To the best of our knowledge, 1 of the largest series to date is a report of 21 breast cancer patients with 22 irradiated breasts who had undergone breast-conserving therapy and XRT. 25 Approximately 56% of patients were able to lactate, but the volume of milk production was significantly diminished in 80% of the treated breasts. Similarly, Tralins reported on the breastfeeding abilities of 53 women treated for breast cancer with XRT who subsequently became pregnant but had limited success breastfeeding because of decreased milk production.…”

Section: Discussionmentioning

confidence: 98%

“…Existing studies of breastfeeding after cancer treatment are largely confined to breast cancer patients, and are either anecdotal or involve relatively small populations. [19][20][21][22][23][24][25][26] In a 1991 case report and review, Varsos and Yahalom reported on a survivor of unilateral breast cancer and noted full lactation in her untreated breast, but decreased milk production in the irradiated breast. The authors cautioned against breastfeeding from an irradiated breast secondary to an absence of data regarding the milk's safety for the infant.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Breastfeeding in survivors of Hodgkin lymphoma treated with chest radiotherapy

McCullough

Najita

et al. 2010

Cancer

View full text Add to dashboard Cite

BACKGROUND: Female survivors of therapeutic chest radiation often question whether they will have difficulty with breast feeding, given their prior exposure to breast radiation. In the current study, the rates of successful breastfeeding in long-term survivors who received chest radiotherapy (CXRT) as a treatment for Hodgkin lymphoma (HL) were examined. METHODS: A survey study of survivors of HL who were treated at the Joint Center for Radiation Therapy in Boston from 1969 through 1996 was performed. Patients were queried about childbearing and breastfeeding. The authors analyzed self-reported breastfeeding success in women who reported live births after CXRT and compared them with a sibling control group. RESULTS: Overall, 83 female survivors of HL who were treated with CXRT reported at least 1 birth after treatment. There were a total of 141 post-HL pregnancies resulting in births. In these women, the median age at the time of the HL diagnosis was 23 years (range, 14-40 years) and the median radiation dose was 41 grays (Gy) (range, 27-46 Gy). For survivors, 57 of the 94 (61%) breastfeeding attempts were successful, whereas within the control group, 74 of the 94 (79%) attempts were successful (P ¼.044). Accounting for maternal age at first birth and birth era, multivariable analysis suggested that HL survivors treated with CXRT may be less likely to breastfeed successfully than their siblings (odds ratio, 0.42; 95% confidence interval, 0.2-1.0 [P ¼.06]). CONCLUSIONS: The majority of female HL survivors who were treated with CXRT report being able to breastfeed successfully. However, the results of the current study indicate a trend toward less successful breastfeeding in survivors as a previously unreported late effect of radiation. Cancer 2010;116:4866-71.

show abstract

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Breastfeeding in survivors of Hodgkin lymphoma treated with chest radiotherapy

McCullough

Najita

et al. 2010

Cancer

View full text Add to dashboard Cite

show abstract

“…However, lactation from an irradiated breast may not be possible, or may occur only with a diminished capacity. 310,311 The panel recommends that women on an adjuvant aromatase inhibitor or who experience ovarian failure secondary to treatment should have monitoring of bone health, with a bone mineral density determination at baseline and periodically thereafter. The use of estrogen, progesterone, or selective ER modulators to treat osteoporosis or osteopenia in women with breast cancer is discouraged.…”

Section: 294mentioning

confidence: 99%

Breast Cancer Version 3.2014

Gradishar¹,

Anderson²,

Blair³

et al. 2014

J Natl Compr Canc Netw

176

117

View full text Add to dashboard Cite

“…De qualquer forma, o aleitamento na mama irradiada não é recomendado devido ao risco da mulher desenvolver mastite, que, caso ocorra, será de manejo delicado. 27,28 A maioria das drogas (principalmente, os agentes alquilantes) é excretada no leite humano. De forma geral, a lactação deve ser evitada durante a quimioterapia, uso de transtuzumab, lapatinib e terapia endócrina.…”

Section: Lactaçãounclassified

Câncer de mama na gravidez: Diagnóstico e Tratamento

Monteiro

Menezes

Nunes

et al. 2014

Revista Hospital Universitário Pedro Ernesto

View full text Add to dashboard Cite

ResumoO objetivo do estudo é avaliar o diagnóstico e a terapêutica do câncer de mama em gestantes, visto que a gravidez pode potencialmente gerar retardo na abordagem da doença e, consequentemente, pior prognóstico do que na mulher não gestante. Associa-se ainda o baixo índice de suspeição da doença neste período e relutância de médicos e pacientes em realizar testes radiográficos e procedimentos invasivos. O câncer de mama é a neoplasia maligna feminina mais frequente. Sua incidência na gestação é baixa, variando de 1:3000 a 1:10.000 gravidezes, apresentando-se geralmente em estágio avançado durante a gravidez. A condução do caso frequentemente gera dificuldades e angústia para a gestante, sua família e para os profissionais de saúde envolvidos, em função do dilema criado entre a terapia ideal para a mãe e o bem-estar do feto. O diagnóstico baseia-se no teste triplo que consiste em exame clínico, imagem e biópsia, visando avaliar a extensão da doença na mama e nos linfonodos, identificar múltiplos focos ou eventual tumor bilateral, bem como prevenir metástases sistêmicas e controlar localmente a doença. O adiamento da terapêutica, a fim de proteger o concepto, pode comprometer a saúde materna. A mastectomia radical modificada e a radical clássica podem ser utilizadas com segurança. Deve-se realizar o esvaziamento axilar, pois metástases são comumente encontradas na gravidez e o comprometimento linfonodal influencia na escolha da quimioterapia. Evidências sugerem segurança e eficácia do esquema 5-fluorouracil, doxorrubicina (ou epirrubicina) e ciclofosfamida durante o segundo e o terceiro trimestres da gestação. A radioterapia deve ser adiada, sempre que possível, para depois do parto. Este estudo visa ainda incentivar o exame das mamas durante o exame ginecológico de rotina e pré-natal, conscientizando paciente e equipe de saúde de sua importância no ciclo grávido-puerperal. Descritores:Câncer de mama; Gravidez; Diagnóstico; Tratamento. AbstractThe aim of the study is to evaluate diagnosis and treatment of breast cancer in pregnant women, since pregnancy can potentially generate delay in disease approach and consequently worst prognosis than in non-pregnant women. There is also a low index of suspicion of the disease in this period and reluctance of patients and physicians to perform radiographic tests and invasive procedures. Breast cancer is the most common female malignancy. Its incidence in pregnancy is low, ranging from 1:3000 to 1:10,000 pregnancies, usually presenting at an advanced stage during pregnancy. The disease management often generates difficulties and distress for the mother, her family and health professionals involved, depending on the dilemma created between the ideal therapy for the mother and fetus welfare. Diagnostic approach is based on triple test consisting of clinical, imaging and biopsy examination to evaluate disease extension in breast and lymph nodes, identify possible multiple foci or bilateral tumors, and prevent systemic metastasis and manage local disease. Therapy delay in ord...

show abstract

Effects of Breast-Conserving Therapy on Lactation After Pregnancy

Abstract: Patients can experience successful lactation in the contralateral, untreated breast after breast-conserving therapy. In the treated breast, functional lactation is possible but is significantly diminished in the majority of patients.

Cited by 56 publications

References 18 publications

Breastfeeding in survivors of Hodgkin lymphoma treated with chest radiotherapy

Breastfeeding in survivors of Hodgkin lymphoma treated with chest radiotherapy

Breast Cancer Version 3.2014

Câncer de mama na gravidez: Diagnóstico e Tratamento

Contact Info

Product

Resources

About