Effects of breed and adipose depot location on responsiveness and sensitivity to adrenergic stimulation in ovine adipose tissue

Gilson, T.L.; Kennedy, A. D.; Rampersand, T.

doi:10.1016/s0742-8413(96)00070-9

Cited by 3 publications

(7 citation statements)

References 22 publications

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“…The lipolytic sensitivity of different AT to ISO or adrenaline addition in vitro was ten times greater in the fat-tailed Karakul breed than in thin-tailed Outaouais ewes (Gilson et al 1996). This factor could allow the control of fat mobilization by small changes in the secretion of catecholamines, and possibly facilitate the adaptation to seasonal underfeeding in fat-tail ewes.…”

Section: Regulation By Catecholaminesmentioning

confidence: 89%

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Adipose tissue metabolism and its role in adaptations to undernutrition in ruminants

et al. 2000

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Changes in the amount and metabolism of adipose tissue (AT) occur in underfed ruminants, and are amplified during lactation, or in fat animals. The fat depot of the tail of some ovine breeds seems to play a particular role in adaptation to undernutrition; this role could be linked to its smaller adipocytes and high sensitivity to the lipolytic effect of catecholamines. Glucocorticoids and growth hormone probably interact to induce teleophoretic changes in the AT responses to adenosine and catecholamines during lactation. Fat mobilization in dry ewes is related both to body fatness and to energy balance. The in vivo β-adrenergic lipolytic potential is primarily related to energy balance, whereas basal postprandial plasma non-esterified fatty acids (NEFA) are related to body fatness, and preprandial plasma NEFA is the best predictor of the actual body lipid loss. Several mechanisms seem to be aimed at avoiding excessive fat mobilization and/or insuring a return to the body fatness homeostatic set point. As well as providing the underfed animal with fatty acids as oxidative fuels, AT acts as an endocrine gland. The yield of leptin by ruminant AT is positively related to body fatness, decreased by underfeeding, β-adrenergic stimulation and short day length, and increased by insulin and glucocorticoids. This finding suggests that the leptin chronic (or acute) decrease in lean (or underfed respectively) ruminants is, as in rodents, a signal for endocrine, metabolic and behavioural adaptations aimed at restoring homeostasis.

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Section: Regulation By Catecholaminesmentioning

confidence: 89%

“…It is noteworthy that in the Karakul ewe the fat-tail depot has smaller adipocytes and is less responsive in vitro to ISO or adrenaline than other fat depots (Gilson et al 1996). This factor may be involved in the moderate rate of mobilization (Atti & Bocquier, 1999) of this particular fat depot.…”

Section: Relationship With Adipose Cell Size or Body Fatnessmentioning

confidence: 96%

Adipose tissue metabolism and its role in adaptations to undernutrition in ruminants

et al. 2000

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“…Inconsistent with the present research, Gruber et al (2007) did not observe an interaction of various biological cattle types and RAC supplementation. Reason for inconsistencies between studies is unclear, but could involve direct (e.g., tissue specific) and indirect (e.g., endocrine) changes associated with fat and muscle metabolism (Gilson et al, 1996). Although, both alpha and beta-adrenergic receptors are present in ovine adipose tissue (Watt et al, 1991), variations in the sensitivity and responsiveness of individual adipose depots to cathecholamines stimulation have been demonstrated in lambs.…”

Section: Discussionmentioning

confidence: 99%

“…Variations in the sensitivity of RAC on specific lamb breed could be due to differences of adiposities characteristics and basal lipolysis (Zamiri and Izadifard, 1995). Thus, the elevated sensitivity of wool lambs to RAC could be indicative of greater beta-adrenergic receptor affinity and higher number of receptor than hair lambs (Gilson et al, 1996).…”

Section: Discussionmentioning

confidence: 99%

“…Also, these recommendations are based on trials using only hair lambs. An elevated sensitivity of wool lambs to RAC could be indicative of greater beta-adrenergic receptor affinity and higher number of receptor than hair lambs (Gilson et al, 1996) then we hypothesized that RAC effect might be different in wool and hair lambs. Therefore, the objective of this study was to determine the best dose level of RAC in diet for growth performance and carcass traits on wool and hair lambs.…”

Section: Introductionmentioning

confidence: 99%

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Effects of Ractopamine Hydrochloride on Growth Performance and Carcass Characteristics in Wool and Hair Lambs

Romero-Maya¹,

Herrera-Haro²,

Pinos-Rodríguez³

et al. 2013

Italian Journal of Animal Science

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This study aimed at evaluating the effects of ractopamine hydrochloride (RAC) on growth performance and carcass characteristics of wool and hair lambs. For this purpose, 48 lambs averaging 31.3 kg body weight, of which twenty were wool (Ramboullet x Suffolk) and twenty eight were hair (Tabasco) lambs, and four levels of RAC (0, 10, 20, and 30 mg/kg diet, dry matter basis) were used. Wool lambs fed 20 and 30 mg RAC had higher (P<0.05) total gain weight and lower feed conversion than 0 and 10 mg RAC. Wool lambs fed 20 mg RAC had the highest carcass weight, dressing, legs weight and longissimus area as compared to 0, 10 and 30 mg RAC. In hair lambs there were not effect of RAC on growth performance and carcass characteristics. It was concluded that addition of RAC to finishing diets offered the best growth performance and carcass traits in wool lambs as compared to hair lambs.

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Responses of body fat mobilization to isoproterenol or epinephrine challenge in adult cows: influence of energy level, breed, and body fatness

Ferlay

Chilliard

2018

Journal of Animal Science

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The sustainability of livestock production systems facing climatic or economic changes is linked in part to the potential of the female ruminants to adapt to feeding constraints through metabolic and hormonal regulation, notably responses of body fat mobilization, depending on adipose tissue (AT) lipolysis. Our hypothesis was that these responses could change according to genotype (breed) and body fatness. Six fat, nonpregnant, nonlactating Charolais cows, six fat Holstein cows, and six lean Holstein cows were used in a 2 × 2 crossover design with two treatments (underfeeding or overfeeding, at 62% [low] or 128% [high] of maintenance energy requirements [MER], respectively) and two periods. Isoproterenol (ISO, a nonselective β-adrenergic agonist) or epinephrine (EPI, a β- and α2-adrenergic agonist) was injected (6 nmol/kg of lean mass). Blood samples were collected regularly from -20 to 75 min after the injection and then were analyzed for NEFA, glycerol, glucose, and L-lactate. Underfeeding greatly increased (P < 0.001) basal plasma NEFA concentrations (+467%, +264%, and +600% for fat Charolais, fat Holstein, and lean Holstein cows, respectively). For each drug, underfed cows had higher NEFA or glycerol responses to adrenergic challenges than overfed cows. Fat Charolais cows had higher basal plasma NEFA (P < 0.05) concentrations (+64.9%) than fat Holstein cows. The plasma NEFA or glycerol response at 5 min (P < 0.05) was higher for fat Charolais than for fat Holstein cows, whatever the injected drug. Basal plasma lactate concentration and lactate response to ISO or EPI were higher (P < 0.05) for fat Charolais cows than for fat Holstein cows. Fat Holstein cows had higher (P < 0.01) basal glycerol (+18.4%) than lean Holstein cows. This increase could be linked to the increased AT mass. ISO increased more lipolytic responses in fat than in lean Holstein cows, whereas EPI increased more these responses in lean than in fat Holstein cows (drug × fatness interaction), suggesting an increased antilipolytic effect due to α2-AR stimulation in fat cows. Breed had a significant effect on basal and stimulated fat mobilization as well as lactate concentrations, suggesting that the Charolais breed could be more sensitive to stress.

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Effects of breed and adipose depot location on responsiveness and sensitivity to adrenergic stimulation in ovine adipose tissue

Cited by 3 publications

References 22 publications

Adipose tissue metabolism and its role in adaptations to undernutrition in ruminants

Adipose tissue metabolism and its role in adaptations to undernutrition in ruminants

Effects of Ractopamine Hydrochloride on Growth Performance and Carcass Characteristics in Wool and Hair Lambs

Responses of body fat mobilization to isoproterenol or epinephrine challenge in adult cows: influence of energy level, breed, and body fatness

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