2003
DOI: 10.1016/s0021-9290(02)00245-2
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Effects of broad frequency vibration on cultured osteoblasts

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Cited by 164 publications
(111 citation statements)
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“…For example, accelerations may generate drag forces that perturb osteocytic processes in the pericellular matrix, 41 providing a strong amplification mechanism for even very small mechanical events. 42 However, cells might respond to vibrations even in absence of their native environment in vitro, 43,44 perhaps modulated by oscillations of the nucleus in the cytoplasm. 45 Nevertheless, a generic cell response to vibrations is inconsistent with the sitespecific responses observed here, and mechanical factors could interact with physiological (e.g., altered blood flow [46][47][48] ) and cellular (e.g., cell communication 49 ) factors to define the tissue-level response.…”
Section: Discussionmentioning
confidence: 99%
“…For example, accelerations may generate drag forces that perturb osteocytic processes in the pericellular matrix, 41 providing a strong amplification mechanism for even very small mechanical events. 42 However, cells might respond to vibrations even in absence of their native environment in vitro, 43,44 perhaps modulated by oscillations of the nucleus in the cytoplasm. 45 Nevertheless, a generic cell response to vibrations is inconsistent with the sitespecific responses observed here, and mechanical factors could interact with physiological (e.g., altered blood flow [46][47][48] ) and cellular (e.g., cell communication 49 ) factors to define the tissue-level response.…”
Section: Discussionmentioning
confidence: 99%
“…Alternatively, cells grown on a porous but stiff substrate can be exposed to a transmembrane pressure, an elevated pressure on the apical surface relative to that in the region beneath the cells (67). To simulate certain physiological conditions, cells can be embedded in gels or tissues and subjected to compression with the use of pistons linked to motors or actuators (78). Alternatively, excised vessels can be internally pressurized with media, producing simultaneous vessel wall strain and hydrostatic pressure (52).…”
Section: Techniques For Mechanically Probing Cellsmentioning
confidence: 99%
“…Yet only very limited data are available on the interaction between mechanical loading and MMPs or TIMPs in osteoblasts. Tanaka et al 15 found MMP-9 mRNA was elevated 1.3-fold after 7 days of vibration with sinusoidal strain on mouse osteoblasts in collagen gels. Recently, Yang et al 16 reported induction of MMP-13 mRNA (2.8-fold) and MMP-13 activity (twofold) after uniaxial mechanical strain in mouse osteoblastic cell line MC3T3-E1.…”
Section: Introductionmentioning
confidence: 99%