Effects of bromantan on offspring maturation and development of reflexes

Iezhitsa, Igor Nikolayevich; Спасов, А. А.; Бугаева, Л. И.

doi:10.1016/s0892-0362(01)00119-2

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2006

2024

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Cited by 23 publications

(9 citation statements)

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“…This phenomenon may be explained as a toxic effect of benzene, similar to that found for other agents applied during prenatal life (Dorman et al, 2000;Iezhitsa et al, 2001;Kleven et al, 2004).…”

Section: Discussionsupporting

confidence: 69%

Long-lasting neurotoxicity of prenatal benzene acute exposure in rats

et al. 2006

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Section: Discussionsupporting

confidence: 69%

Long-lasting neurotoxicity of prenatal benzene acute exposure in rats

et al. 2006

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“…This is indicative of a delay in maturational development as a result of exposure to xenobiotics. The changes in their development and expression could represent a predictive factor for other behavioural modifications in adulthood [27].…”

Section: Discussionmentioning

confidence: 99%

Neurobehavioural effects of exposure to fluoride in the earliest stages of rat development

Bartos

Gumilar

Bras

et al. 2015

Physiology & Behavior

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“…Mid-air righting normally develops in mice around postnatal day 14 and reflects the development of dynamic postural adjustments mediated by the cerebellum (Iezhitsa et al, 2001; Petrosini et al, 1990). As with surface righting, mice of both genotypes were successful in mid-air righting prior to treatment with valproic acid.…”

Section: Discussionmentioning

confidence: 99%

Altered behavioral development in Nrf2 knockout mice following early postnatal exposure to valproic acid

Furnari

Saw

Kong

et al. 2014

Brain Research Bulletin

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Early exposure to valproic acid results in autism-like neural and behavioral deficits in humans and other animals through oxidative stress-induced neural damage. In the present study, valproic acid was administered to genetically altered mice lacking the Nrf2 (nuclear factor-erythroid 2 related factor 2) gene on postnatal day 14 (P14). Nrf2 is a transcription factor that induces genes that protect against oxidative stress. It was found that valproic acid-treated Nrf2 knockout mice were less active in open field activity chambers, less successful on the rotorod, and had deficits in learning and memory in the Morris water maze compared to the valproic acid-treated wild type mice. Given these results, it appears that Nrf2 knockout mice were more sensitive to the neural damage caused by valproic acid administered during early development.

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Effects of bromantan on offspring maturation and development of reflexes

Cited by 23 publications

References 2 publications

Long-lasting neurotoxicity of prenatal benzene acute exposure in rats

Long-lasting neurotoxicity of prenatal benzene acute exposure in rats

Neurobehavioural effects of exposure to fluoride in the earliest stages of rat development

Altered behavioral development in Nrf2 knockout mice following early postnatal exposure to valproic acid

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