Effects of Bronchial Intermittent Constrictions on Explosive Flow during Coughing in the Dogs

Hayama, Naoki; Kondo, Tetsuri; Kobayashi, Ichiro; Tazaki, Gen; Eguchi, Katsumi

doi:10.2170/jjphysiol.53.71

Cited by 4 publications

(4 citation statements)

References 18 publications

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“…Additional defense mechanisms associated with cough are bronchoconstriction and mucus secretion [8]. It has been reported [10, 13, 14] that the interplay of cough, bronchoconstriction, and mucus secretion can result in a less-effective expulsive cough phase, particularly when the cause of the pathological condition persists.…”

mentioning

confidence: 99%

“…Furthermore, there are some additional and controversial mechanisms associated with cough that may or may not increase its effectiveness: bronchoconstriction and mucus secretion [8]. Excessive bronchial mucus secretion may cause coughing, but on the other hand, coughing may evoke reflex airway mucus secretion that can interfere with the expulsive phase [10, 14]. In addition, O’ Donnel et al [13] have reported that, in some cases, excessive bronchoconstriction during coughing may reduce its expulsive effect.…”

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confidence: 99%

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A specific laryngeal finding in dogs with bronchial vegetal foreign bodies: a retrospective study of 63 cases

Marchesi

Caivano

Conti

et al. 2019

The Journal of Veterinary Medical Science

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Grass awns commonly cause respiratory disease in dogs; when located in the trachea or bronchi, they cause severe bronchial inflammation and sepsis. The interplay of cough, bronchoconstriction, and mucus secretion can result in a less effective expulsive cough phase, especially when the causal factor persists. The bronchial exudate could consequently become trapped in the upper respiratory tracts of dogs with bronchial vegetal foreign bodies. We retrospectively reviewed endoscopic findings of the upper respiratory tract in dogs that underwent bronchoscopy in our hospital and correlated these findings with the presence of bronchial grass awns. Muco-purulent exudate in the ventral larynx region, between the vocal cords and laryngeal ventricles, was frequently associated with the presence of bronchial grass awns. This laryngeal finding could be secondary to an altered response to grass awn localization in the bronchi. These results should be carefully considered, particularly in countries where grass awns are commonly found.

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confidence: 99%

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confidence: 99%

A specific laryngeal finding in dogs with bronchial vegetal foreign bodies: a retrospective study of 63 cases

Marchesi

Caivano

Conti

et al. 2019

The Journal of Veterinary Medical Science

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“…However we considered this method unsatisfactory for at least two reasons. First, the abrupt opening of the airway shutter in these methods could have provided an explosive initial flow resembling that of a cough [7,8]. PEFR accompanying a cough is always higher than that of a forced expiration [8].…”

Section: Methodsmentioning

confidence: 99%

“…These results suggest that the peak flow in rats was limited by a choke point. Since even in larger animals such as dogs flow limitation can occur at the trachea [7,13], limitation of the peak flow may occur at the trachea in rats.…”

Section: Flow-volume Curvementioning

confidence: 99%

Spirometric and flow-volume curve analysis in rats, and optimal parameters for estimating obstructive impairment

et al. 2010

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We obtained flow-volume (F-V) curves in anesthetized rats by applying positive pressure on the body surface. To obtain the best curve, tracheal intubation with either a 12 or 13 gauge catheter and a surface pressure greater than 56 cmH(2)O was necessary. Peak expiratory flow rate (PEFR) and forced vital capacity (FVC) were shown to be optimal parameters for estimation of bronchoconstriction induced by methacholine inhalation while FEV(0.05) (forced expiratory volume at 0.05 s) and FEV(0.10) were of limited usefulness for this purpose. The descending segment of the F-V curve consisted of two or three phases, with later phases shortened during bronchoconstriction. In conclusion, PEFR and FVC are optimal parameters for estimation of bronchoconstriction in rats. The decreases in PEFR and FVC may reflect constriction in large and smaller airways, respectively.

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Models used in the development of antitussive drugs

Mackenzie

Spina

Page

2004

Drug Discovery Today: Disease Models

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Effects of Bronchial Intermittent Constrictions on Explosive Flow during Coughing in the Dogs

Cited by 4 publications

References 18 publications

A specific laryngeal finding in dogs with bronchial vegetal foreign bodies: a retrospective study of 63 cases

A specific laryngeal finding in dogs with bronchial vegetal foreign bodies: a retrospective study of 63 cases

Spirometric and flow-volume curve analysis in rats, and optimal parameters for estimating obstructive impairment

Models used in the development of antitussive drugs

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