Effects of brown alga, Ecklonia cava on glucose and lipid metabolism in C57BL/KsJ-db/db mice, a model of type 2 diabetes mellitus

Lee, Seung‐Hong; Min, Kweon Sik; Han, Ji-Sook; Lee, Dae-Ho; Park, Deok-Bae; Jung, Won‐Kyo; Park, Pyo-Jam; Jeon, Byong-Tae; Kim, Se‐Kwon; Jeon, You‐Jin

doi:10.1016/j.fct.2011.12.032

Cited by 91 publications

(66 citation statements)

References 47 publications

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“…However, the level of HDL cholesterol was shown to be slightly increased in the groups treated with high-doses of SN and DK (Table 2). These results were also observed in Lee's study, which used a dieckol-rich extract [5]. In many studies, body weight and lipid parameters such as, total cholesterol, LDL cholesterol, and triacylglycerol was shown to be increased in diabetes [14].…”

Section: Plasma and Hepatic Lipid Profilessupporting

confidence: 68%

“…In addition, the food efficiency ratio (FER, total weight gain/total food intake) was significantly decreased in the SN and DK groups supplementation; SNHD reduced the FER by 49%, whereas DKLD and DKHD decreased the FER by 54% and 67%, respectively ( Table 1). The decrease in water intake in the Rosi and SN/DK groups was also observed in Lee's study [5]. However, the SN/DK-mediated decrease in the final body weight in db/db mice was shown to be different from that of the study performed by Lee et al, which did not show a significant difference with the supplementation of the dieckol-rich extract of Ecklonia cava.…”

Section: Food and Water Intake And Body Weightcontrasting

confidence: 48%

“…They have been known to exert various biological effects including anti-inflammatory and anti-oxidant effects [3,4]. A previous study demonstrated that the dieckol-rich extract of Ecklonia cava has an anti-diabetic effect against type 2 diabetes by improving glucose/lipid metabolism and the activity of antioxidant enzymes [5]. However, the mechanism of action underlying the antidiabetic effect of the major Ecklonia cava-derived compound has yet to be investigated.…”

Section: Introductionmentioning

confidence: 99%

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Seapolynol and Dieckol Improve Insulin Sensitivity through the Regulation of the PI3K Pathway in C57BL/KsJ-db/db Mice

Jeon¹,

Yoon²,

Koh³

et al. 2015

JFNR

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Ecklonia cava, a brown alga native to the seas of Korea and Japan, contains biologically active polyphenols. Seapolynol (SN) is a polyphenol mixture derived from Ecklonia cava, and dieckol (DK) is a major compound of SN. Both Ecklonia cava-derived polyphenols exert an anti-diabetic effect in C57BL/KsJ-db/db mice. SN and DK supplementation significantly reduced bodyweight, water intake, fasting blood glucose, and plasma insulin levels compared with db/db mice. In addition, C-peptide, a biomarker of insulin secretion, was significantly decreased by SN and DK treatment, whereas plasma adiponectin levels, which are associated with insulin sensitivity, was increased by two-fold compared with the db/db group. Regarding plasma lipid profiles, triacylglycerol, total cholesterol, and low-density lipoprotein (LDL) cholesterol, were effectively reduced in the SN-and DK-treated groups. Moreover, the administration of SN and DK activated the insulin signaling pathway, as indicated by the levels of receptor substrate-1 (IRS-1), phosphoinositide 3-kinase (PI3K), serine-threonine specific protein kinase (Akt), and glucose transporter type 4 (GLUT4) in diabetic mice. This result showed that SN and DK regulate blood glucose levels by improving insulin sensitivity in the diabetic condition. Our data suggest that SN and DK may be anti-diabetic agents.

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Section: Plasma and Hepatic Lipid Profilessupporting

confidence: 68%

Section: Food and Water Intake And Body Weightcontrasting

confidence: 48%

Section: Introductionmentioning

confidence: 99%

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Seapolynol and Dieckol Improve Insulin Sensitivity through the Regulation of the PI3K Pathway in C57BL/KsJ-db/db Mice

Jeon¹,

Yoon²,

Koh³

et al. 2015

JFNR

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“…These algae are rich in vitamins, minerals, dietary fibers, essential fatty acids, enzymes, polysaccharides, and various functional polyphenols. Almost all the algae species had good ability to scavenge free radicals [8].…”

Section: Introductionmentioning

confidence: 99%

Investigation of the Antiasthmatic Properties of Ethanol Extract of <i>Callophyllis japonica</i> in Mice

Park¹,

Lee²,

Chun³

et al. 2014

Trop. J. Pharm Res

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“…Fucosterol lessened lipid contents in a concentration-dependent manner without showing any cytotoxicity. It was found that Fucosterol treatment effected the expression of several adipocyte marker proteins such as peroxisome proliferator-activated receptor γ (PPARγ) and CCAAT/enhancer-binding protein α (C/EBPα) by decreasing their levels 36 .…”

Section: Fucosterols From Turbinaria Speciesmentioning

confidence: 99%

Manifestation of Metabolic Syndrome by Turbinaria Species: A Review

Mishra¹,

Kumar²,

Juyal³

et al. 2017

Int. Res. J. Pharm.

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Metabolic disorder refers to a cluster of metabolic abnormalities (i.e., insulin resistance, hypertension, dyslipidemia, obesity, high cholesterol and high blood pressure). The metabolic disorder is fast becoming a global emergency. Drugs presently available in the market help in curing the disorder only up to some extent and providing symptomatic relief, in lieu of an array of side effects, hence it is the need of the hour to look for alternative strategy for prevention and treatment of metabolic syndrome. Marine natural products are a source of antihypertensive, antihyperglycemic, antioxidative, and anticancer agents possibly useful in the treatment or in the prevention of metabolic disorders. Through this review we have made an effort to throw some light on potential uses of the marine sea weed, a genus of brown algae Turbinaria (Phaeophyceae) as a potential agent for the treatment and amelioration of metabolic syndrome and related disorder, we have briefed about various chemical constituents found in the different species of Turbinaria and the role they can play in achieving the above said goal.

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Effects of brown alga, Ecklonia cava on glucose and lipid metabolism in C57BL/KsJ-db/db mice, a model of type 2 diabetes mellitus

Cited by 91 publications

References 47 publications

Seapolynol and Dieckol Improve Insulin Sensitivity through the Regulation of the PI3K Pathway in C57BL/KsJ-db/db Mice

Seapolynol and Dieckol Improve Insulin Sensitivity through the Regulation of the PI3K Pathway in C57BL/KsJ-db/db Mice

Investigation of the Antiasthmatic Properties of Ethanol Extract of <i>Callophyllis japonica</i> in Mice

Manifestation of Metabolic Syndrome by Turbinaria Species: A Review

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