Effects of BT-11 on memory in healthy humans

Lee, Jun-Young; Kim, Ka Young; Shin, Ki Young; Won, Beom Young; Jung, Hee Yeon; Suh, Yoo‐Hun

doi:10.1016/j.neulet.2009.03.024

Cited by 44 publications

(30 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…PRP has been reported to possess sedative activity [8]. RP shows repairing effects on the memory and behavioral deficits in rats [9], exhibits neuroprotective effects [10], [11], enhances cognition and memory in elderly adults [12], [13]. This study was to assess the efficacy of SS against AD.…”

Section: Introductionmentioning

confidence: 99%

Smart Soup, a Traditional Chinese Medicine Formula, Ameliorates Amyloid Pathology and Related Cognitive Deficits

Wang

Zhao

et al. 2014

PLoS ONE

View full text Add to dashboard Cite

Alzheimer’s disease (AD) is a progressive neurodegenerative disease that causes substantial public health care burdens. Intensive efforts have been made to find effective and safe disease-modifying treatment and symptomatic intervention alternatives against AD. Smart Soup (SS), a Chinese medicine formula composed of Rhizoma Acori Tatarinowii (AT), Poria cum Radix Pini (PRP) and Radix Polygalae (RP), is a typical prescription against memory deficits. Here, we assessed the efficacy of SS against AD. Oral administration of SS ameliorated the cognitive impairment of AD transgenic mice, with reduced Aβ levels, retarded Aβ amyloidosis and reduced Aβ-induced gliosis and neuronal loss in the brains of AD mice. Consistently, SS treatment reduced amyloid-related locomotor dysfunctions and premature death of AD transgenic Drosophila. Mechanistic studies showed that RP reduced Aβ generation, whereas AT and PRP exerted neuroprotective effects against Aβ. Taken together, our study indicates that SS could be effective against AD, providing a practical therapeutic strategy against the disease.

show abstract

Section: Introductionmentioning

confidence: 99%

Smart Soup, a Traditional Chinese Medicine Formula, Ameliorates Amyloid Pathology and Related Cognitive Deficits

Wang

Zhao

et al. 2014

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…Modern pharmacological studies have already demonstrated that Polygalae Radix extract exhibits a wide variety of effects, such as hypotensive [7] , anti-inflammatory [8] , anti-depressive [9] , anti-oxidative and antiapoptotic [10] effects, cognitive improvements and cerebral protection [11] . The Polygalae Radix extract BT-11 has been shown to have memory-enhancing effects in rats with scopolamineinduced amnesia [12] and cognition-improving effects in two randomized, double-blind, placebo-controlled comparison studies, one in healthy adults and one in elderly humans [13,14] . However, the biologically active components of Polygalae Radix extract remains unclear, and additional preclinical studies are necessary to develop more effective monomers from Polygalae Radix extracts.…”

Section: Introductionmentioning

confidence: 99%

Polygalasaponin XXXII, a triterpenoid saponin from Polygalae Radix, attenuates scopolamine-induced cognitive impairments in mice

et al. 2016

View full text Add to dashboard Cite

Aim: Recent studies show that the extract of a Chinese herb Polygalae Radix exerts cognition-enhancing actions in rats and humans. The aim of this study was to characterize the pharmacological profiles of active compounds extracted from Polygalae Radix. Methods: Two fractions P3 and P6 and two compounds PTM-15 and polygalasaponin XXXII (PGS32) were prepared. Neuroprotective effects were evaluated in primary cortical neurons exposed to high concentration glutamate, serum deficiency or H 2 O 2 . Anti-dementia actions were assessed in scopolamine-induced amnesia in mice using step-through avoidance tests and channel water maze tests. After conducting the channel water maze tests, TrkB phosphorylation in mouse hippocampus was detected using Western blotting. Long-term potentiation (LTP) was induced in the dentate gyrus in adult rats; PGS32 (5 μL 400 μmol/L) was injected into the lateral cerebral ventricle 20 min after high frequency stimulation (HFS). Results: Compared to the fraction P6, the fraction P3 showed more prominent neuroprotective effects in vitro and cognitionenhancing effects in scopolamine-induced amnesia in mice. One active compound PGS32 in the fraction P3 exerted potent cognitionenhancing action: oral administration of PGS32 (0.125 mg· kg -1 ·d -1 ) for 19 days abolished scopolamine-induced memory impairment in mice. Furthermore, PGS32 (0.5 and 2 mg· kg -1 ·d -1 ) significantly stimulated the phosphorylation of TrkB in the hippocampus. Intracerebroventricular injection of PGS32 significantly enhanced HFS-induced LTP in the dentate gyrus of rats. Conclusion: PGS32 attenuates scopolamine-induced cognitive impairments in mice, suggesting that it has a potential for the treatment of cognitive dysfunction and dementia.

show abstract

“…An ethanolic extract from the Polygala tenuifolia root BT-11 improved scopolamine and stress induced amnesia in rats and has memory-enhancing effects in healthy adults [44,45,141] …”

Section: Bt-11mentioning

confidence: 99%

Traditional Korean East Asian Medicines and Herbal Formulations for Cognitive Impairment

Kumar

Song

et al. 2013

Molecules

View full text Add to dashboard Cite

Abstract:Hanbang, the Traditional Korean Medicine (TKM), is an inseparable component of Korean culture both within the country, and further afield. Korean traditional herbs have been used medicinally to treat sickness and injury for thousands of years. Oriental medicine reflects our ancestor's wisdom and experience, and as the elderly population in Korea is rapidly increasing, so is the importance of their health problems. The proportion of the population who are over 65 years of age is expected to increase to 24.3% by 2031. Cognitive impairment is common with increasing age, and efforts are made to retain and restore the cognition ability of the elderly. Herbal materials have been considered for this purpose because of their low adverse effects and their cognitive-enhancing or anti-dementia activities. Herbal materials are reported to contain several active compounds that have effects on cognitive function. Here, we enumerate evidence linking TKMs which have shown benefits in memory improvements. Moreover, we have also listed Korean herbal formulations which have been the subject of scientific reports relating to memory improvement.

show abstract

Effects of BT-11 on memory in healthy humans

Cited by 44 publications

References 16 publications

Smart Soup, a Traditional Chinese Medicine Formula, Ameliorates Amyloid Pathology and Related Cognitive Deficits

Smart Soup, a Traditional Chinese Medicine Formula, Ameliorates Amyloid Pathology and Related Cognitive Deficits

Polygalasaponin XXXII, a triterpenoid saponin from Polygalae Radix, attenuates scopolamine-induced cognitive impairments in mice

Traditional Korean East Asian Medicines and Herbal Formulations for Cognitive Impairment

Contact Info

Product

Resources

About