Effects of buprenorphine, carprofen and saline on thermal and mechanical nociceptive thresholds in cats

Steagall, Paulo V.; Taylor, Polly; Brondani, Juliana Tabarelli; Luna, Stélio Pacca Loureiro; Dixon, Mike J.; Ferreira, Tiago

doi:10.1111/j.1467-2995.2006.00331.x

Cited by 52 publications

(85 citation statements)

References 34 publications

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“…Despite the wide use of SC drugs in dogs, the efficacy of SC tramadol for pain control after surgery is not well documented. Although previous studies have investigated the SC administration of tramadol in red-eared sliders [20], chicks [21], and cats [22], none have assessed its efficacy in dogs. This study aimed to compare tramadol's efficacy when administered SC versus IV as a postoperative analgesic agent in dogs undergoing routine ovariohysterectomy (OHE).…”

Section: Introductionmentioning

confidence: 99%

Subcutaneous Administration of Tramadol after Elective Surgery Is as Effective as Intravenous Administration in Relieving Acute Pain and Inflammation in Dogs

Salisu

Hashim

Goh

et al. 2012

The Scientific World Journal

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Subcutaneous (SC) administration of tramadol was compared with intravenous (IV) administration to evaluate analgesia following canine ovariohysterectomy (OHE). Healthy female dogs (n = 12) between 1 and 3 years of age (1.95 ± 0.65 years), weighing between 10.5 and 17.1 kg (13.12 ± 1.95 kg), were used. Pain was assessed at baseline before surgery and then hourly for 8 hr after surgery. Tramadol was administered both SC and IV at a dose of 3 mg/kg and provided significant postoperative analgesia, as indicated by analgesiometry, β-endorphin levels, and interleukin 6 (IL-6) levels. The respiratory rates and rectal temperatures remained normal and were not significantly different between or within the groups. A significant increase in heart rate was observed at 4 hr for dogs in both groups relative to the baseline, but there was no significant difference in heart rates between the groups at any time point. A significant decrease in mechanical pain threshold was observed within each group after surgery, but both groups responded similarly, suggesting that SC administration of tramadol is as effective as IV administration. Increased serum levels of both IL-6 and β-endorphin 3 hr postoperatively further indicate that both routes of administration achieve similar pain control. Thus, the relative analgesic efficacy of SC tramadol is comparable to that of IV administration and can be used to achieve similar effects for postsurgical pain management in dogs undergoing OHE.

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Section: Introductionmentioning

confidence: 99%

Subcutaneous Administration of Tramadol after Elective Surgery Is as Effective as Intravenous Administration in Relieving Acute Pain and Inflammation in Dogs

Salisu

Hashim

Goh

et al. 2012

The Scientific World Journal

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“…cattle: Veissier et al, 2000) and may be particularly useful as they are able to predict subsequent behaviours. Measurement of reflex responses may therefore avoid the need to assess more overt behavioural responses, such as jumping or biting at the device, used in other thermal assessments of nociception and pain in cats (Slingsby et al, 2010;Steagall et al, 2007Steagall et al, , 2008.…”

Section: Introductionmentioning

confidence: 99%

Body weight affects behavioural indication of thermal nociceptive threshold in adult domestic cats (Felis catus)

Farnworth

Barrett

Adams

et al. 2013

Applied Animal Behaviour Science

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a b s t r a c tCarbon dioxide (CO 2 ) thermal lasers have previously been validated for the assessment of nociception in cats. This experiment sought to assess the potential impact of factors associated with age, sex, body weight and sterilisation upon nociceptive threshold as measured by latency to display a behavioural response. Cats (N = 113) were exposed to a CO2 thermal laser three times during a 45-60 min test period depending upon the interval between tests. A minimum of 15 min elapsed between consecutive tests on any one individual. Time to display either a skin twitch or withdrawal was measured. Intra-class correlations showed the three measurements to be repeatable across tests for any given cat (ICC = 0.482; P < 0.001). Males had a significantly longer mean latency to respond than females (14.83 s and 12.59 s respectively; P = 0.028). Analyses of co-variance established that the body weight of females significantly affected response threshold (P = 0.013) but for males this effect was marginal (P = 0.058). All other factors included in the analyses were non-significant. A post hoc ttest for males and females with overlapping body weights found no significant differences between the sexes (P = 0.721). The precise reason for the effect of body weight on latency to respond is unknown and further exploration is needed particularly as it relates to subcutaneous fat deposition and skin temperature. It is concluded that, for cats, the body weight of the subject should be standardised or included in any analyses for assessment of nociception. Inclusion of body weight data in analyses may also prove useful when using a CO2 laser protocol in other species.

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“…O analgesiômetro utilizado no presente estudo foi validado e desenvolvido para detectar o limiar nociceptivo mecânico em gatos, representando um papel importante no estudo da analgesia nessa espécie (STEAGALL et al, 2007). No presente estudo, em nenhum caso, foi necessário o acionamento do sistema de segurança para prevenir lesão tecidual, visto que todos os animais responderam ao estímulo na pressão máxima de 401mmHg.…”

Section: Discussionunclassified

“…Trabalhos empregando o analgesiômetro demonstraram efeito antinociceptivo com a utilização de diversos opioides, como a buprenorfina, a metadona, o butorfanol e a morfina; e outros agentes, como o tramadol e a acepromazina (STEAGALL et al, 2006;DIXON et al, 2007;STEAGALL et al, 2007;2009). Entretanto, contrariando esses resultados, a administração isolada da buprenorfina e da acepromazina no presente estudo não promoveu elevação significativa do limiar nociceptivo mecânico.…”

Section: Discussionunclassified

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Efeitos antinociceptivos e sedativos da buprenorfina, da acepromazina ou da associação buprenorfina e acepromazina em gatos

Santana

Luna

Steagall³

et al. 2010

Cienc. Rural

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O efeito antinociceptivo da buprenorfina tem sido relatado em cães e gatos. No presente estudo, avaliou-se o limiar nociceptivo mecânico em felinos tratados com buprenorfina, acepromazina ou ambas associadas e foram comparados os efeitos antinociceptivos e sedativos da associação em relação ao uso isolado desses fármacos determinados pelo mesmo observador, por meio de analgesiômetro e da escala analógica visual dinâmica interativa (DIVAS), respectivamente. Os oito animais empregados no estudo foram previamente familiarizados com os procedimentos utilizados. Após quatro mensurações basais, foram administrados, por via intramuscular, 0,02mg kg-1 de buprenorfina, 0,06mg kg-1 de acepromazina ou 0,01mg kg-1 de buprenorfina associada a 0,03mg kg-1 de acepromazina, em um estudo cego, com delineamento em quadrado latino e tratamento semanal. Os efeitos antinociceptivos e sedativos foram avaliados aos 15, 30, 45 minutos e uma, duas, três, quatro, seis, oito e 12 horas após a administração do tratamento. O limiar nociceptivo mecânico se elevou significativamente apenas no grupo tratado com a associação buprenorfina-acepromazina (entre 45 minutos e uma hora). Em relação à sedação, nos grupos tratados com acepromazina e com a associação, os valores da DIVAS foram significativamente maiores, respectivamente, de 15 minutos até quatro horas e de 15 minutos até três horas pós-tratamento, não apresentando elevação desses valores com a buprenorfina. Concluiu-se que não foi possível verificar a superioridade da neuroleptoanalgesia em relação ao uso dos fármacos isoladamente.

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Effects of buprenorphine, carprofen and saline on thermal and mechanical nociceptive thresholds in cats

Cited by 52 publications

References 34 publications

Subcutaneous Administration of Tramadol after Elective Surgery Is as Effective as Intravenous Administration in Relieving Acute Pain and Inflammation in Dogs

Subcutaneous Administration of Tramadol after Elective Surgery Is as Effective as Intravenous Administration in Relieving Acute Pain and Inflammation in Dogs

Body weight affects behavioural indication of thermal nociceptive threshold in adult domestic cats (Felis catus)

Efeitos antinociceptivos e sedativos da buprenorfina, da acepromazina ou da associação buprenorfina e acepromazina em gatos

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