“…Studies of the treatment effectiveness of maintenance doses of buprenorphine are few compared to those of methadone, and the results are mixed. However, on measures of retention rates and illicit opioid use, buprenorphine has been found to be as effective as, or better than, methadone when prescribed at higher doses (8-16 mg/day) (Foltin and Fischman, 1996;Johnson et al, 1992;Kosten et al, 1988;Ling et al, 1996;Schottenfeld et al, 1997;Strain et al, 1994aStrain et al, , b, 1996, whereas lower dose regimens (2-4 mg/ day) are less effective (Greenwald et al, 2002;Ling et al, 1998;Montoya et al, 2004). Furthermore, there are reports that buprenorphine maintenance reduces craving for cocaine (Foltin and Fischman, 1996) and, to varying degrees, reduces cocaine consumption as measured by urine analysis in human opioid addicts (Johnson et al, 1992;Kosten et al, 1988;Ling et al, 1996;Schottenfeld et al, 1997;Strain et al, 1994aStrain et al, , b, 1996.…”