Effects of buspirone on plasma prolactin and cortisol levels in major depressed and normal subjects

Meltzer, Herbert Y.; Maes, Michaël

doi:10.1016/0006-3223(94)90035-3

Cited by 71 publications

(30 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, in agreement with previous studies [7,13,14], we found no differences in baseline PRL levels between control subjects and depressed patients without hypercortisolemia. Treatment with sertraline for 4 or 24 weeks did not affect PRL values in our study.…”

Section: Discussionsupporting

confidence: 82%

See 1 more Smart Citation

Effects of Sertraline Treatment on Plasma Cortisol, Prolactin and Thyroid Hormones in Female Depressed Patients

et al. 2002

View full text Add to dashboard Cite

The aim of the study was to evaluate the effects of 4 and 24 weeks of sertraline treatment (average dose 42.5 mg/day) on plasma hormone levels in 15 female patients with major depression. Baseline levels of triiodothyronine (T₃) were lower, while cortisol, prolactin (PRL), thyroid-stimulating hormone (TSH), and thyroxin (T₄) levels did not differ from the values in 16 female controls. There was a positive correlation between the scores on the Montgomery-Asperg Depression Rating Scale and baseline cortisol levels. Treatment with sertraline for 4 weeks increased plasma cortisol levels, while 24 weeks of sertraline treatment increased plasma T₃ levels in depressed patients. Neither 4, nor 24 weeks of sertraline treatment affected PRL, T₄ and TSH levels in depressed patients. The data show different and time-dependent effects of sertraline treatment on plasma cortisol, PRL and thyroid hormones in female depressed patients.

show abstract

Section: Discussionsupporting

confidence: 82%

“…Serotonergic precursors, releasing agents and direct agonists increase [11], and 5-HT antagonists decrease [12] plasma PRL levels. In depressed patients, plasma PRL levels have been shown to be decreased [13] or unchanged [7,14] compared with control subjects.…”

Section: Introductionmentioning

confidence: 99%

Effects of Sertraline Treatment on Plasma Cortisol, Prolactin and Thyroid Hormones in Female Depressed Patients

et al. 2002

View full text Add to dashboard Cite

show abstract

“…Evidence in support of this hypothesis comes from the fact that previous positive studies have in general involved inpatients or melancholic patients [9][10][11][12]25] while negative studies have comprised outpatients or nonmelancholic patients (table 2) [14,15]. This was further supported by the observation that there was a significant positive correlation between the HAMD scores and the hypothermic response to ipsapirone but not with other variables such as age, sex, BMI, dose of ipsapirone, Shiah/Yatham/Lam/Tam/Zis and medication, etc.…”

Section: Discussionmentioning

confidence: 85%

“…Furthermore, a subsensitivity of postsynaptic 5-HT 1A receptors in depression has also been suggested by the studies that showed a reduction in prolactin response to buspirone [11], and a reduction in cortisol response to ipsapirone [12,13] in patients with major depression compared to normal controls. Some other investigators, however, were unable to find such a significant reduction in the hypothermic [14] or hormonal responses [9,14,15] to 5-HT 1A receptor agonists in patients with major depression compared to normal controls.…”

Section: Introductionmentioning

confidence: 97%

Cortisol, Hypothermic, and Behavioral Responses to Ipsapirone in Patients with Bipolar Depression and Normal Controls

Shiah

Yatham²,

Lam³

et al. 1998

Neuropsychobiology

View full text Add to dashboard Cite

To examine if 5-HT_1A receptor function is involved in the pathophysiology of bipolar depression, we measured the cortisol, hypothermic and behavioral responses to ipsapirone, a 5-HT_1A receptor agonist, in 8 patients with bipolar depression and 26 normal controls. After obtaining blood samples for baseline cortisol levels and measuring baseline body temperature, a single dose of 0.3 mg/kg of ipsapirone was administered orally to all the subjects, and further blood and temperature readings were obtained every 30 min for 3 h. The results showed that the administration of ipsapirone led to a significant increase in cortisol release and a significant decrease in body temperature both in bipolar depressed patients and normal controls. There was no significant difference in the cortisol or hypothermic responses to ipsapirone between groups. However, there was a significant positive correlation between the Hamilton Depression Rating (HAMD) scores and the hypothermic response in the depressed patients, while the HAMD scores were not significantly correlated with the cortisol response. Comparing our findings with those of previous studies, we suggest that the alterations in 5-HT_1A receptor sensitivity in depressed patients may be related to the severity of depression, and they may only occur in more severely depressed patients.

show abstract

“…However, two recent studies reported no buspirone-induced neuroendocrine changes, Le. PRL and cortisol, in depressed patients (Meltzer and Maes, 1994;Cowen et al 1994). Despite the controversy, the bulk of the accumulated evidencc support the hypothesis that 5-HT1A postsysnaptic responses are attenuated in major depression.…”

mentioning

confidence: 99%

Serotonin1A Receptor Activation by Flesinoxan in Humans Body Temperature and Neuroendocrine Responses

Seletti

Benkelfat

Blier

et al. 1995

Neuropsychopharmacology

View full text Add to dashboard Cite

Effects of buspirone on plasma prolactin and cortisol levels in major depressed and normal subjects

Cited by 71 publications

References 47 publications

Effects of Sertraline Treatment on Plasma Cortisol, Prolactin and Thyroid Hormones in Female Depressed Patients

Effects of Sertraline Treatment on Plasma Cortisol, Prolactin and Thyroid Hormones in Female Depressed Patients

Cortisol, Hypothermic, and Behavioral Responses to Ipsapirone in Patients with Bipolar Depression and Normal Controls

Serotonin1A Receptor Activation by Flesinoxan in Humans Body Temperature and Neuroendocrine Responses

Contact Info

Product

Resources

About