Effects of butylated hydroxyanisole on the development and functions of reproductive system in rats

Jeong, Sang‐Hee; Kim, Byung-Yong; Kang, Hae‐Eun; Ku, Hyun-Ok; Cho, Joon-Hyoung

doi:10.1016/j.tox.2004.11.014

Cited by 71 publications

(57 citation statements)

References 38 publications

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“…Excessively high concentrations of BHA could also induce the production of ROS and lead to subsequent membrane damage. Jeong et al (2005) reported that BHA could enhance the activities of hepatic phase II enzymes such as glutathione s-transferase and UDP-glucuronyltransferase in mice, both involved in the elimination of reactive oxygen species (ROS). Similar results were noted in the present study through the increase of GST and CAT activity in S. obliquus, especially for CAT.…”

Section: Discussionmentioning

confidence: 99%

Effects of norfloxacin and butylated hydroxyanisole on the freshwater microalga Scenedesmus obliquus

Nie

et al. 2009

Ecotoxicology

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The toxic effects of norfloxacin (NOR) and butylated hydroxyanisole (BHA) on the microalga Scenedesmus obliquus were assessed in terms of growth rate, concentration of chlorophyll a, activities of 7-ethoxyresorufin-o-dealkylases (EROD), glutathione s-transferase (GST), catalase (CAT) and total malondialdehyde content (MDA). The 96 h EC(50) was 38.49 and 11.12 mg/l for NOR and BHA, respectively. Growth of S. obliquus was affected slightly under low concentrations of BHA (<4 mg/l) and NOR (<15 mg/l) over the 96 h exposure period. With the increasing concentrations of these two compounds, growth of S. oblique decreased significantly. Growth inhibition was 82.4% at 60.0 mg/l for NOR and 60.6% at 16.0 mg/l for BHA after 96 h. A similar trend was also observed for chlorophyll alpha. NOR and BHA affected Phase I and Phase II enzyme activities differently. Upon exposure to NOR, EROD was induced at concentration <15.0 mg/l and depressed at concentrations >30 mg/l significantly. CAT and GST exhibited similar trends during the exposure period. Compared to controls, MDA content only showed high induction at high concentrations of NOR (>30 mg/l). However, EROD activity did not display any change compared to control responses during BHA exposure, whereas GST showed significant induction for all concentrations over the exposure period. CAT activity showed induction at low concentration and depression at high concentration. MDA content increased with the rise of BHA during the exposure period. These types of assays, revealing toxic effects of NOR and BHA to phototrophs, could be employed to assess the potential risks of these xenobiotics to aquatic ecological systems.

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Section: Discussionmentioning

confidence: 99%

Effects of norfloxacin and butylated hydroxyanisole on the freshwater microalga Scenedesmus obliquus

Nie

et al. 2009

Ecotoxicology

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“…In order to inhibit lipid oxidation and bacterial growth in foods, many synthetic food preservatives are widely used in raw and processed food (Frankel, 1993). However, some synthetic food preservatives, such as butylated hydroxyanisole (BHA), have been reported to have side effects and may be harmful to human health (Jeong, Kim, Kang, Ku, & Cho, 2005;Maeura & Williams, 1984). In addition, there are growing concerns among people about the safety of foods containing synthetic chemicals.…”

Section: Introductionmentioning

confidence: 99%

Pigmented edible bean coats as natural sources of polyphenols with antioxidant and antibacterial effects

Gan

Deng

Yan

et al. 2016

LWT

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“…BHA is one of the most common stable synthetic phenolic antioxidants, and previous studies have demonstrated that BHA has protective capacity in preventing cell death induced by Shikonin (Park et al, 2013) and that BHA plays a role in the oxidative processes in rats (Jeong et al, 2005;Sanchez-Gallego et al, 2011). Wattenberg LW found the protective effect of BHA on chemical carcinogenesis and the change of the chemical carcinogens' metabolism (Wattenberg, 1986(Wattenberg, , 1975.…”

Section: Figmentioning

confidence: 99%

Adverse effect of sub-chronic exposure to benzo(a)pyrene and protective effect of butylated hydroxyanisole on learning and memory ability in male Sprague-Dawley rat

et al. 2014

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-Previous studies demonstrate that benzo(a)pyrene (B(a)P) can affect hippocampal function and cause spatial cognition impairment. However, the mechanism is incomplete. Some evidence implies that B(a)P may cause an oxidative damage linking to the function of the hippocampus and antioxidant can prevent the oxidative damage in rats, but the ATPase and Ca 2+ in the hippocampus and the protective effect of butylated hydroxyanisole (BHA) have not been studied. This study aimed to investigate the damage of toxicity further induced by B(a)P in hippocampus and the protective effect of BHA. Ninety-six male Sprague-Dawley (SD) rats were randomly divided into four groups (solvent control group, BHA-group, B(a)P-exposed group and B(a)P-BHA-combination group), with daily administration for 90 days. Morris water maze (MWM) was employed to evaluate the learning and memory ability. The levels of malonaldehyde (MDA) content, superoxide dismutase (SOD) activity, Na + -K + -ATPase and Ca 2+ -Mg 2+ -ATPase activity in hippocampus were measured by commercial kits. The concentration of Ca 2+ in rat hippocampus was detected by fluorescent labeling. In behavior test it showed that there was an adverse effect on rats in the B(a)P -group. The levels of MDA content and Ca 2+ content were significantly increased in the B(a)P group, while the activities of SOD and ATPase were significantly decreased. In the B(a)P-BHA group, the change of each index diminished significantly. The results suggested that the neurobehavioral toxicity of B(a)P might have a close relationship with oxidative damage, resulted in decreasing of ATPase activities and increasing of Ca 2+ concentration in the hippocampus. Furthermore, BHA can prevent these damages.

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Effects of butylated hydroxyanisole on the development and functions of reproductive system in rats

Cited by 71 publications

References 38 publications

Effects of norfloxacin and butylated hydroxyanisole on the freshwater microalga Scenedesmus obliquus

Effects of norfloxacin and butylated hydroxyanisole on the freshwater microalga Scenedesmus obliquus

Pigmented edible bean coats as natural sources of polyphenols with antioxidant and antibacterial effects

Adverse effect of sub-chronic exposure to benzo(a)pyrene and protective effect of butylated hydroxyanisole on learning and memory ability in male Sprague-Dawley rat

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