Effects of butylated hydroxytoluene on the enzyme activity and ultrastructure of rat hepatocytes

Botham, Christine M.; Conning, D. M.; Hayes, Joanne; Litchfield, M. H.; McElligott, T. F.

doi:10.1016/s0015-6264(70)80217-6

Cited by 52 publications

(2 citation statements)

References 7 publications

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“…Neither enzyme activity nor SER increased at the 0.01% BHT level. Both increased at the 1% level (about 500 mg/kg/day), but they returned to control values after cessation of BHT administration (Botham et al, 1970). Also the phase I1 enzyme activities of the UDP-glucuronosyltransferase isozymes increased in the liver, small intestine and kidney of male rats given 0.5% BHT (about 250 mg/kg/day) in the diet for 2 weeks.…”

Section: Effects After Repeated Exposures In Animalsmentioning

confidence: 90%

Indoor Air Guideline Levels for Phenol and Butylated Hydroxytoluene (BHT)

Nielsen¹,

Hansen²,

Nexø³

et al. 1998

Indoor Air

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Sensory and health effects of phenol and butylated hydroxytoluene (BHT) are evaluated based on published literature, and guideline values for exposure limits in indoor air are proposed. The sensory effects are evaluated from odour thresholds and exposure limits preventing sensory irritation, i.e. irritation of eyes and nose. Health effects are evaluated from two types of effect: firstly lung effects and non‐carcinogenic systemic effects; and secondly genotoxic and carcinogenic effects. Both types of effect were evaluated with a view to setting guideline values.

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Section: Effects After Repeated Exposures In Animalsmentioning

confidence: 90%

Indoor Air Guideline Levels for Phenol and Butylated Hydroxytoluene (BHT)

Nielsen¹,

Hansen²,

Nexø³

et al. 1998

Indoor Air

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show abstract

“…1966). Instead there was marked proliferation of agranular endoplasmic reticulum (Lane & Lieber 1967;Botham et al 1970), and an increase in the drug metabolizing enzymes (Gilbert & Golberg 1965) and an increase in protein synthesis in liver microsomes (Nievel 1969). Therefore, the haemorrhage due to BHT was not caused by necrosis of liver cells as in rats given hepatotoxin.…”

Section: Haemaiological Values Serum Components and Enzyme Activitiementioning

confidence: 99%

Haemorrhagic Toxicosis in Rats Given Butylated Hydroxytoluene

Takahashi

Hiraga

1981

Acta Pharmacologica et Toxicologica

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Vascular permeability, platelet function, blood coagulation and fibrinolytic activity were examined in Sprague-Dawley male rats given 1.20% butylated hydroxytoluene (BHT) in the diet for 1 week. BHT significantly increased the leakage of Evans blue from blood into epididymus. BHT inhibited the ADP-induced platelet aggregation and decreased the platelet factor 3 availability. Plasmaprothrombin, factors IX, X, VII and VIII were decreased in rats given BHT. Fibrinolytic activity was little influenced by BHT-feeding.

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Role of dietary lipids and butylated hydroxy anisol (BHA) administration on albino rats. Part II. Liver and heart unsaturated fatty acids

Abu‐El‐Zahab

Aida

El-Sisi

1993

Nahrung

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Adult male albino rats were supplemented with edible plant oils, corn maize and cotton seed oils and their semihydrogenated forms (Heliopolis and Sultan cooking fat). In general, the supplementation of tested oils produced increasing effect on the levels of total unsaturated fatty acids (UFA), C18:1, C18:2 and C20:4 UFA of liver and heart of rats. Liver content of UFA showed very highly significant increases in the levels of C18:1 and C18:2 in all groups of rats fed with tested oils accompanied with non significant changes in total UFA and C20:4 levels. Heart content of UFA showed increases in the levels of C18:1 and C18:2 and insignificant changes observed in total UFA and C20:4, except, in rats fed with sultan cooking fat, showed a significant increase in the level of total UFA. The level of increase in C18:1 and C18:2 was very highly significant in case of rats fed corn maize oil and Sultan cooking fat, and significant in case of rats fed cotton seed oil and Heliopolis cooking fat. Also, liver and heart UFA contents were significantly increased after antioxidant (Butylated hydroxy anisol, BHA) administration. Addition of BHA to tested diets abolished or minimized fatty infiltration produced by dietary fatty diet in the liver cells.

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Effects of butylated hydroxytoluene on the enzyme activity and ultrastructure of rat hepatocytes

Cited by 52 publications

References 7 publications

Indoor Air Guideline Levels for Phenol and Butylated Hydroxytoluene (BHT)

Indoor Air Guideline Levels for Phenol and Butylated Hydroxytoluene (BHT)

Haemorrhagic Toxicosis in Rats Given Butylated Hydroxytoluene

Role of dietary lipids and butylated hydroxy anisol (BHA) administration on albino rats. Part II. Liver and heart unsaturated fatty acids

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