Effects of caatinga propolis from Mimosa tenuiflora and its constituents (santin, sakuranetin and kaempferide) on human immune cells

Sartori, Arthur Alves; Son, Ninh The; da Silva Honorio, Mariana; Ripari, Nicolas; Santiago, Karina Basso; Gomes, Anderson Moreira; Zambuzzi, Willian Fernando; Bastos, Jairo Kenupp; Sforcin, José Maurício

doi:10.1016/j.jep.2023.117297

Cited by 9 publications

(5 citation statements)

References 32 publications

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“…Phytochemical research of the alcoholic extract of M. tenuiflora green propolis led to the isolation of six compounds 1-6 (Figure 1). Their NMR spectroscopic data (Figures S1-S12) match well with previous reports, including two flavones quercetin 3methyl ether (1) and 3,3'-O-dimethylquercetin (2), and four flavanones eriodictyol 5-O-methyl ether (3), 5,4'-dihydroxy-6,7dimethoxyflavanone (4), licoflavanone (5), and macarangaflavanone B (6). [6][7][8][9][10][11] From previous studies, propolis from Asian and European regions contained a significant concentration of flavonoids, while Brazilian propolis was only accompanied by terpenoids and prenylated coumaric acids.…”

Section: Phytochemical Isolation and Chemotaxonomysupporting

confidence: 87%

“…[4] It was documented that chemical constituents from M. tenuiflora green propolis are appropriate for immune response. [5] In this study, we aim to report the chromatographic separation of flavonoid derivatives from Northeast-Brazil Caatinga M. tenuiflora green propolis, and their role in chemotaxonomy. Their pharmacological values in antioxidative, antiinflammatory, anti-bacterial, and mosquito larvicidal studies have also been considered.…”

Section: Introductionmentioning

confidence: 99%

“…The green tint of Caatinga propolis is evidenced by the salivary enzymes that bees utilize to break up shoot apices and mix them with wax to make propolis [4] . It was documented that chemical constituents from M. tenuiflora green propolis are appropriate for immune response [5] . In this study, we aim to report the chromatographic separation of flavonoid derivatives from Northeast‐Brazil Caatinga M. tenuiflora green propolis, and their role in chemotaxonomy.…”

Section: Introductionmentioning

confidence: 99%

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Flavonoids from Mimosa tenuiflora Green Propolis: Chemotaxonomy, Antioxidant, Anti‐Inflammation, Anti‐Bacteria, Mosquito Larvicidal Activity, and In Silico Approach

Luyen,

Hao,

Bastos

et al. 2024

ChemistrySelect

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Phytochemical study of green propolis alcohol extract of Brazilian Caatinga Mimosa tenuiflora (Willd.) Poir resulted in the separation of six flavonoids, including quercetin 3‐methyl ether (1) and 3,3′‐O‐dimethylquercetin (2), and four flavanones eriodictyol 5‐O‐methyl ether (3), 5,4′‐dihydroxy‐6,7‐dimethoxyflavanone (4), licoflavanone (5), and macarangaflavanone B (6). All these metabolites were first isolated from green propolis and the genus Mimosa. Metabolites 3–4 also established chemotaxonomic significance since they had never been observed in the bean family Fabaceae. Flavones 1–2 showed strong antioxidative activity against DPPH (1,1‐diphenyl‐2‐picryl hydrazyl) radicals with IC50 values of 12.40 and 16.23 μg/mL, respectively. All six isolates showed anti‐inflammatory effects against NO (nitric oxide) production in LPS (lipopolysaccharide)‐stimulated Raw 264.7 cells, in which the activity of flavone 1 was better than the standard dexamethasone (IC50 13.35 μg/mL). Flavonoids 1–3 also strongly controlled the growth of the Gram‐positive bacteria Bacillus subtilis ATCC 6051, and Staphylococcus aureus ATCC 29213 with MIC values of 32–64 μg/mL. Six isolated flavonoids exhibited strong or moderate mosquito larvicidal activity against Aedes aegypti and Ae. albopictus fourth instar larvae with the 24 h LC50 values of 29.62–55.89 μg/mL. By in silico approach, compound 1 was a non‐toxic agent with an LD50 value of 5000 mg/kg.

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Section: Phytochemical Isolation and Chemotaxonomysupporting

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Flavonoids from Mimosa tenuiflora Green Propolis: Chemotaxonomy, Antioxidant, Anti‐Inflammation, Anti‐Bacteria, Mosquito Larvicidal Activity, and In Silico Approach

Luyen,

Hao,

Bastos

et al. 2024

ChemistrySelect

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“…In this scenario, Brazilian green propolis is a promising source of vasoactive compounds. Recent works, in fact, demonstrated that isolates from green propolis of the Caatinga Mimosa tenuiflora are either bi-functional vasodilators 9 or provided with anti-inflammatory properties 10 . Therefore, an in-depth analysis of several flavonoids isolated from this natural product has been performed in the search for other effective vasorelaxant agents.…”

Section: Introductionmentioning

confidence: 99%

Vasorelaxant Activity of (2S)-Sakuranetin and Other Flavonoids Isolated from the Green Propolis of the Caatinga Mimosa tenuiflora

Son,

Gianibbi,

Panti

et al. 2024

Planta Med

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Some in vitro and in vivo evidence is consistent with the cardiovascular beneficial activity of propolis. As the single actors responsible for this effect have never been identified, an in-depth investigation of flavonoids isolated from the green propolis of the Caatinga Mimosa tenuiflora was performed and their mechanism of action was described. A comprehensive electrophysiology, functional, and molecular docking approach was applied. Most flavanones and flavones were effective CaV1.2 channel blockers with a potency order of (2S)-sakuranetin > eriodictyol-7,3′-methyl ether > quercetin 3-methyl ether > 5,4′-dihydroxy-6,7-dimethoxyflavanone > santin > axillarin > penduletin > kumatakenin, ermanin and viscosine being weak or modest stimulators. Except for eriodictyol 5-O-methyl ether, all the flavonoids were also effective spasmolytic agents of vascular rings, kumatakenin and viscosine also showing an endothelium-dependent activity. (2S)-Sakuranetin also stimulated KCa1.1 channels both in single myocytes and vascular rings. In silico analysis provided interesting insights into the mode of action of (2S)-sakuranetin within both CaV1.2 and KCa1.1 channels. The green propolis of the Caatinga Mimosa tenuiflora is a valuable source of multi-target vasoactive flavonoids: this evidence reinforces its nutraceutical value in the cardiovascular disease prevention arena.

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“…The main chemicals in propolis are flavonoids, polyphenols and terpenes [17][18][19]. The potential pharmacological activity of propolis is very broad for health with improvement of immune system [20] and there has been a lot of research ranging from in silico, in vitro to clinical studies regarding the effects of propolis on health [21,22]. Apart from that, propolis also has several biological activities, including antioxidant [23], anti-inflammatory [24], antibacterial, antifungal, and antiviral [25].…”

Section: Introductionmentioning

confidence: 99%

New insights of propolis nanoformulation and its therapeutic potential in human diseases

Kustiawan,

Syaifie,

Siregar

et al. 2024

ADMET DMPK

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Background and purpose: Scientific research is crucial to develop therapies for various disease severity levels, as modern drugs cause side effects and are difficult to predict. Researchers are exploring herbal alternatives with fewer side effects, particularly propolis, which has been validated through in vitro, in vivo, and clinical studies. This will focus on scientific evidence and its supporting technology for developing new bioactive compounds for chronic diseases. Nanotechnology can improve the delivery and absorption of herbal medicines, which often have poor bioavailability due to their high molecular weight and solubility in water, particularly in oral medicines. This technology can enhance propolis's effects through multi-target therapy and reduce side effects. Experimental approach: All publications related to each section of this review were discovered using the search engines Google Scholar, Scopus, and Pubmed. This was only available for publication between 2013 and 2023. The selected publications were used as references in this review after being thoroughly studied. Key results: Evaluation of propolis active compounds, the classification of propolis nano formulations, design concepts, and mechanisms of action of propolis nano formulation. Additionally, the challenges and prospects for how these insights can be translated into clinical benefits are discussed. Conclusion: In the last ten years, a list of nanoformulation propolis has been reported. This review concludes the difficulties encountered in developing large-scale nanoformulations. To commercialize them, improvements in nano carrier synthesis, standardized evaluation methodology within the framework of strategy process improvement, and Good Manufacturing Practices would be required.

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Effects of caatinga propolis from Mimosa tenuiflora and its constituents (santin, sakuranetin and kaempferide) on human immune cells

Cited by 9 publications

References 32 publications

Flavonoids from Mimosa tenuiflora Green Propolis: Chemotaxonomy, Antioxidant, Anti‐Inflammation, Anti‐Bacteria, Mosquito Larvicidal Activity, and In Silico Approach

Flavonoids from Mimosa tenuiflora Green Propolis: Chemotaxonomy, Antioxidant, Anti‐Inflammation, Anti‐Bacteria, Mosquito Larvicidal Activity, and In Silico Approach

Vasorelaxant Activity of (2S)-Sakuranetin and Other Flavonoids Isolated from the Green Propolis of the Caatinga Mimosa tenuiflora

New insights of propolis nanoformulation and its therapeutic potential in human diseases

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