Effects of cachaça, a typical Brazilian alcoholic beverage, on submandibular glands of rats: a histomorphometric and biochemical study

Prá, Ketelin Juliane Dal; Silva, Aneliza de Fatima Moraes da; Chaves‐Neto, Antônio Hernandes; Soubhia, Ana Maria Pires

doi:10.1007/s00784-020-03290-9

Cited by 5 publications

(5 citation statements)

References 29 publications

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“…Some reports associates their sensitivity in media exposed to the toxic chemical compounds. [66,67] In addition, phosphatases are markers of programmed cell death in salivary systems of various types of insects. [68,69] In the present study, the ACP and ALP activities of the VA group were increased in all parts of the salivary glands as compared to the control group.…”

Section: Resultsmentioning

confidence: 99%

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Reversal of Valproate‐Induced Major Salivary Gland Changes By Moringa Oleifera Extract in Rats

Cergel,

Tuzuner,

Turkyilmaz

et al. 2024

Chemistry & Biodiversity

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This study aimed to explore the potential protective impacts of Moringa oleifera extract on major alteration in salivary glands of rats exposed to sodium valproate (VA). Groups were defined as control, control + moringa extract, sodium valproate, and sodium valproate + moringa extract. Antioxidant and oxidant status, activities of digestive and metabolic enzymes were examined. VA treatment led to various biochemical changes in the salivary glands, including decreased levels of antioxidants like glutathione, glutathione‐S‐transferase, and superoxide dismutase (except for sublingual superoxide dismutase). Conversely, a decrease in alpha‐amylase, alkaline and acid phosphatase, lactate dehydrogenase, protease, and maltase activities were observed. The study also demonstrated that VA induces oxidative stress, increases lipid peroxidation, sialic acid, and nitric oxide levels in the salivary glands. Total oxidant capacity was raised in all glands except in the sublingual gland. The electrophoretic patterns of proteins were similar. Moringa oleifera extract exhibited protective properties, reversing these VA‐induced biochemical changes due to its antioxidant and therapeutic attributes. This research suggests that moringa extract might serve as an alternative treatment approach for individuals using VA and experiencing salivary gland issues, although further research is necessary to confirm these findings in human subjects.

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Section: Resultsmentioning

confidence: 99%

“…Their altered activities are associated with many toxicities. Some reports associates their sensitivity in media exposed to the toxic chemical compounds [66,67] . In addition, phosphatases are markers of programmed cell death in salivary systems of various types of insects [68,69] .…”

Section: Resultsmentioning

confidence: 99%

Reversal of Valproate‐Induced Major Salivary Gland Changes By Moringa Oleifera Extract in Rats

Cergel,

Tuzuner,

Turkyilmaz

et al. 2024

Chemistry & Biodiversity

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“…Another study evaluated the impact of ethanol consumption on the salivary glands through saliva analysis, and also observed alterations in the functional biochemical system in response to the toxic effect of ethanol through assessment of the enzymatic activity of total acid phosphatase (TAP) and tartrate-resistant acid phosphatase (TRAP). The researchers noticed a progressive reduction in both activities in the submandibular glands of rats exposed to chronic consumption of cachaça for 75-105 days, in addition to reduced mucin levels in the exposed group [12]. The metabolization of ethanol produces acetaldehyde, which is linked to greater production of ROS.…”

Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

“…Thus, alcohol use disorders are associated with the risk of alcoholic liver disease, cardiovascular diseases, pancreatitis, cancers, malnutrition problems, brain damage, and fetal alcohol spectrum disorders[3,8,9]. Interestingly, salivary glands are susceptible to biochemical, morphological, and functional damage through different forms of alcohol exposure, both in chronic and binge-like models[12][13][14].Physical activity is defined as any skeletal muscle-driven movement that requires more energy expenditure than usual. For example, it includes tasks related to everyday life, recreation, employment, sports, and active transportation[15,16].…”

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confidence: 99%

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Physical Exercise Mitigates Salivary Gland and Saliva Damages in Rats Exposed to Binge-like Ethanol Pattern

et al. 2023

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Heavy episodic ethanol (EtOH) consumption is a typical pattern, especially among younger people. The therapeutic effect of exercise on EtOH damage has not yet been fully elucidated. Therefore, this study aims to investigate whether moderate exercise can reduce the damage generated by ethanol consumption in salivary glands and saliva. Thus, 32 male Wistar rats were divided into four groups: control (sedentary animals treated with water); training (trained animals treated with EtOH); EtOH (sedentary animals treated with EtOH); and EtOH + training (trained animals treated with ethanol). EtOH was administered to the animals at a dose of 3 g/kg/day at a concentration of 20% w/v for three consecutive days per week via intragastric gavage. The training was performed on a treadmill for five successive days. At the end of the 4-week experimental protocol, the animals were euthanized, and salivary glands and saliva were collected for oxidative biochemistry analysis. Our results showed that EtOH consumption generated changes in the oxidative biochemistry of the salivary glands and saliva. Thus, it was possible to conclude that moderate physical exercise can significantly recover antioxidant activity, reducing the damage generated by EtOH.

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Assessment of redox state and biochemical parameters of salivary glands in rats treated with anti-obesity drug sibutramine hydrochloride

et al. 2022

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Effects of cachaça, a typical Brazilian alcoholic beverage, on submandibular glands of rats: a histomorphometric and biochemical study

Cited by 5 publications

References 29 publications

Reversal of Valproate‐Induced Major Salivary Gland Changes By Moringa Oleifera Extract in Rats

Reversal of Valproate‐Induced Major Salivary Gland Changes By Moringa Oleifera Extract in Rats

Physical Exercise Mitigates Salivary Gland and Saliva Damages in Rats Exposed to Binge-like Ethanol Pattern

Assessment of redox state and biochemical parameters of salivary glands in rats treated with anti-obesity drug sibutramine hydrochloride

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