Effects of cadmium and calcium on the fluidity of plasma membranes

Sorensen, Elsie M. B.; Acosta, Daniel; Nealon, D.G.

doi:10.1016/0378-4274(85)90214-0

Cited by 33 publications

(11 citation statements)

References 30 publications

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“…In addition, Tokushige et al [1984] showed that cadmium was a potent NAf-K+ ATPase inhibitor, and toxic effects of cadmium on cell membrane structure and function were well documented by Sorensen et al [1985] and Kunimoto et al [1986]. These characteristics of cadmium and lead are probably responsible for inducing cytogenetic toxicities.…”

Section: Discussionmentioning

confidence: 96%

Studies on cytotoxic and genotoxic effects of cadmium nitrate and lead nitrate in chinese hamster ovary cells

Lin

Lee

Chen

et al. 1994

Environ and Mol Mutagen

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Cadmium nitrate decreased the viability of Chinese hamster ovary (CHO) cells in a concentration-dependent manner; 50% inhibition (IC50) was achieved at 0.015 mM. In contrast, lead nitrate appeared to be less toxic. Neither cadmium nitrate nor lead nitrate significantly increased frequencies of binucleated CHO cells with micronuclei (MN). However, both cadmium nitrate and lead nitrate could augment sister chromatid exchanges (SCEs). Cadmium nitrate induced SCEs with a potency approximately equal to that of mitomycin C and more than 10 times higher than lead nitrate. Cadmium nitrate also increased chromosome aberrations (CAs), which included breaks, acentrics, interchanges, and dicentrics of chromosomes. In addition, cadmium nitrate induced a decrease in the mitotic index (MI), but lead nitrate increased it. In summary, it appears that both of these two heavy metal salts have cytogenetic toxicities with different degrees of effects on the cytotoxicity, MN, CAs, and SCEs in CHO cells. However, SCE was the most sensitive endpoint for indicating mutagenetic effects of cadmium and lead in the present study.

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Section: Discussionmentioning

confidence: 96%

Studies on cytotoxic and genotoxic effects of cadmium nitrate and lead nitrate in chinese hamster ovary cells

Lin

Lee

Chen

et al. 1994

Environ and Mol Mutagen

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“…In rainbow trout copper inhibited sodium uptake via the gills McDonald, 1985, 1987) while in our laboratory cadmium was found to inhibit calcium uptake in tilapia gills (Verbost et al, 1987). In addition, cadmium is known to cause changes in the ionic permeability of plasma membranes (Plishkcr, 1984;Sorensen et al, 1985). Therefore, as a result of gill damage, homeostatic imbalance is likely to occur.…”

Section: Discussionmentioning

confidence: 96%

Effects of water-borne cadmium on plasma cortisol and glucose in the cichlid fish Oreochromis mossambicus

Pratap¹,

Bonga²

1990

Comparative Biochemistry and Physiology Part C: Comparative Pha

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Abstract-1. Freshwater cichlids Oreochromis mossambicus (tilapia) were exposed to 10 ng Cd/1 in ambient water for 2, 4, 14 and 35 days. Plasma cortisol and glucose levels were determined to evaluate if cadmium induced a typical stress response in these fish.2. Exposure to cadmium for 2, 4 and 14 days elicited a significant elevation of plasma cortisol levels. 3. A significant hyperglycemia occurred on days 2 and 4 in cadmium-exposed fish. 4. During long-term exposure to cadmium (35 days), the plasma cortisol and glucose levels returned to control values. This recovery after 35 days indicates the ability of tilapia to adapt to low cadmium concentrations in the ambient water.

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“…High Cd concentrations are known to increase the ionic permeability of the plasma m em brane of the blood cells (Plishker 1984;S0rensen et al 1985). For plasma sodium, con flicting results on the effects of cadmium have been reported for different freshwater and marine teleosts.…”

Section: Water-borne Cadmiummentioning

confidence: 99%

Effect of waterborne and dietary cadmium on plasma ions of the teleostOreochromis mossambicus in relation to water calcium levels

Pratap

Lock

et al. 1989

Arch. Environ. Contam. Toxicol.

101

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Please be advised that this information was generated on 2018-05-08 and may be subject to change.Arch. Environ. Contam. Toxicol. 18, 568-575 (1989) Abstract. The effects of cadmium administered via ambient water or food on plasma ions of the Af rican freshwater cichlid Oreochromis mossambicus were studied for 2, 4, 14, and 35 days, in low cal cium (0.2 mM) and high calcium (0.8 mM) water. In low calcium water, an environmentally relevant concentration of 10 fig/L water-borne cadmium in duced a significant and dramatic hypocalcemia on days 2 and 4. Recovery of plasma calcium was ob served on days 14 and 35. Hypermagnesemia was observed on day 2, but normal levels were already found on day 4. In high calcium water adapted fish, the extent of hypocalcemia and hypermagnesemia was less pronounced than in fish from low calcium water. Water-borne cadmium caused no significant changes in plasma phosphate, sodium, potassium, or osmolality. On days 2 and 4, dietary cadmium (averaging 10 fxg Cd/fish/day) caused hypermagne semia and hypocalcemia in low calcium wateradapted fish. Recovery was observed on days 4 and 14, respectively. In fish from high calcium water, dietary cadmium caused a significant reduction in plasma calcium on day 4 only; plasma magnesium was unaffected. Hyperphosphatemia was apparent on day 14, irrespective of the water calcium con centration. No changes in plasma sodium, potas sium, or osmolality were found.^V r c h i v e a oThe results show that sublethal concentrations of cadmium, administered via the water as well as via the food, affect calcium and magnesium metabo lism in tilapia. High water calcium ameliorates the

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Effects of cadmium and calcium on the fluidity of plasma membranes

Cited by 33 publications

References 30 publications

Studies on cytotoxic and genotoxic effects of cadmium nitrate and lead nitrate in chinese hamster ovary cells

Studies on cytotoxic and genotoxic effects of cadmium nitrate and lead nitrate in chinese hamster ovary cells

Effects of water-borne cadmium on plasma cortisol and glucose in the cichlid fish Oreochromis mossambicus

Effect of waterborne and dietary cadmium on plasma ions of the teleostOreochromis mossambicus in relation to water calcium levels

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