Effects of cadmium and dietary selenium on cytoplasmic and mitochondrial antioxidant defense systems in the heart of rats fed high dietary copper*1

Jamall, Ijaz S.; Sprowls, John J.

doi:10.1016/0041-008x(87)90088-3

Cited by 47 publications

(16 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A decrease in dietary manganese was found to decrease Mn-SOD level in rat heart and kidney without a decrease in GSH-px level [38]. Dietary cadmium reduced activities of cytosolic Se-GSH-px and total SOD in rat heart [39]. Hepatic manganese concentration is homeostatically controlled, and en-Environ.…”

Section: Cd-mn-se-hg-as Clustermentioning

confidence: 96%

“…Surf scoters that feed from the estuarine sediment could be exposed to significant dietary loads. Manganese feeding trials with male chicks have demonstrated a linear relationship between dietary and liver tissue manganese concentrations [39]. The liver Mn levels found for scoters in the northern bays would reflect dietary levels of greater than 3,000 mg/kg, an amount substantially greater than the total Mn (about 500 mg/kg) found in the sediment.…”

Section: Bioaccumulationmentioning

confidence: 98%

See 1 more Smart Citation

Biogeochemical interactions affecting hepatic trace element levels in aquatic birds

Möller

1996

Enviro Toxic and Chemistry

View full text Add to dashboard Cite

Abstract-Knowledge of elemental interactions is important to the toxicological assessment of wildlife in the geochemical environment. This study determines the concentrations of Al, As, B, Ba, Be, Cd, Cr, Cu, Fe, Pb, Li, Mg, Mn, Hg, Mo, Ni, Se, Ag, V, and Zn in aquatic bird liver, fish liver, whole bivalves, insects, and waters in several aquatic ecosystems in northern California. There is evidence of strong in vivo and environmental interactions, including the observation of manganese as a possible cofactor or indicator in selenium bioaccumulation. The nearest neighbor selenium correlation in aquatic bird liver tissue that results from this work is Cd-Mn-Se-HgAs. The correlation of liver selenium to manganese in vivo and the result that the majority of the variance in liver selenium concentration is contained in the manganese term of the regression model relating Se to Cd, Mn, and Hg is new knowledge in the study of aquatic birds. A linear relationship between liver selenium and environmental manganese (water and sediment) is found in the data, suggesting a water chemistry compartmentalization or activation of toxicants. Alternatively, the hepatic concentrations of selenium, manganese, and iron suggest induction of enzymes in response to oxidative stress.

show abstract

Section: Cd-mn-se-hg-as Clustermentioning

confidence: 96%

Section: Bioaccumulationmentioning

confidence: 98%

Biogeochemical interactions affecting hepatic trace element levels in aquatic birds

Möller

1996

Enviro Toxic and Chemistry

View full text Add to dashboard Cite

show abstract

“…This is in accordance with the findings of previous studies. Studies by some authors have shown that Cd inhibits the activity of the majority of enzymes involved in AOS [24,25], inducing an increased production of free radicals, lipid peroxidation Fig. 2 Effect of herbal extract and cadmium exposure on ovarian catalase in developing female rats.…”

Section: Discussionmentioning

confidence: 99%

Effect of Herbal Preparation on Heavy Metal (Cadmium) Induced Antioxidant System in Female Wistar Rats

Roopha¹,

Padmalatha²

2011

J. Med. Toxicol.

View full text Add to dashboard Cite

Cadmium is one of the elements found to damage antioxidant systems in mammals. To ameliorate cadmium toxicity and to prevent oxidative stress, natural products may be useful. In Indian ethnobotanical practice, a mixture of 17 herbal products is used to fortify the reproductive system of women after parturition and to reverse ovarian oxidative stress. Oral administration of this extract to rats exposed to cadmium was useful in reversing oxidative stress. Two different doses of cadmium (50 ppm and 200 ppm) were given to Wistar rats aged 45 and 65 days. An herbal extract derived from 17 plants was administered orally every day at a dose level of 200 mg/kg of body weight to the rats exposed to cadmium. A battery of enzymes involved in antioxidant activity in the ovary, including superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx) and glutathione-s-transferase (GST) were measured in the control, cadmium-exposed rats without treatment and in the cadmium-exposed rats treated with herbal extract. The reduction in SOD, catalase, GPx and GST activity after cadmium exposure improved significantly in the rats treated with the herbal extract (p<0.05). The decrease of antioxidant enzymes due to cadmium exposure was reversed significantly with herbal extract administration. The synergistic effect of each bioactive compound in different herbal extracts requires further study.

show abstract

“…Our results showed that CAT activity was decreased in the liver and kidney, even if this decrease was only significant in the liver, and increased in the heart; no modification of GPX activity was observed. Previous studies have reported a decrease in CAT and GPX activities in rat liver and kidney (Stajn et al, 1997;Laszczyca et al, 1996;Ognjanovic et al, 1995) and an increase in the heart (Jamall and Sprowls, 1987) after chronic administration of Cd. Zikic et al (1998) also showed that another antioxidant enzyme, superoxide dismutase activity could be increased in rat heart by chronic Cd administration, whereas in general it was decreased in other tissues such as the liver (Ossola and Tomaro, 1995), the kidney (Stajn et al, 1997) or in the erythrocytes (Sarkar et al, 1998).…”

Section: Discussionmentioning

confidence: 92%

Metallothionein induction in the liver, kidney, heart and aorta of cadmium and isoproterenol treated rats

Bobillier-Chaumont¹,

Maupoil²,

Berthelot³

2005

J. Appl. Toxicol.

View full text Add to dashboard Cite

Metallothionein (MT), induced in different organs in response to heavy metals and oxidative conditions, exerts antioxidant properties and thus could be implicated in cardiovascular physiopathology. The aim of this study was to investigate the capacity of cadmium (Cd) and isoproterenol to induce in vivo MT not only in rat liver and kidneys but also in heart and aorta. Tissue MT levels, catalase (CAT) and glutathione peroxidase (GPX) activities were assayed at different times after Cd or isoproterenol injection. Cd induced a dose-dependent induction of MT with a higher response in the liver than in the kidney, aorta and heart. The hepatic increase was early (12 h) and maintained (72 h), whereas the elevation was maximal around 48 h for the other organs. Isoproterenol induced a transient (12 h) hepatic and a biphasic (12 and 36 h) renal and cardiac increase. CAT activity was decreased in the liver and increased in the heart with the higher Cd doses. Isoproterenol increased the cardiac GPX activity. In conclusion, the results demonstrate that MT can be induced in rat liver and kidneys but also in heart after a Cd or isoproterenol injection. This enhancement of cardiac and vascular MT levels could be used to study the potential protective effect of MT in cardiovascular diseases.

show abstract

Effects of cadmium and dietary selenium on cytoplasmic and mitochondrial antioxidant defense systems in the heart of rats fed high dietary copper*1

Cited by 47 publications

References 31 publications

Biogeochemical interactions affecting hepatic trace element levels in aquatic birds

Biogeochemical interactions affecting hepatic trace element levels in aquatic birds

Effect of Herbal Preparation on Heavy Metal (Cadmium) Induced Antioxidant System in Female Wistar Rats

Metallothionein induction in the liver, kidney, heart and aorta of cadmium and isoproterenol treated rats

Contact Info

Product

Resources

About