Effects of cadmium and high-fat diet on essential metal concentration in the mouse testis

Zhou, Bin; Gentry, Adrienne; Xu, Qiwu; Young, Jamie L.; Yan, Xin; Pagidas, Kelly; Yang, Yu; Watson, Walter H.; Kong, Maiying; Cai, Lu; Freedman, Jonathan H.

doi:10.1016/j.toxrep.2021.03.016

Cited by 7 publications

(3 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…K + , and Ca 2+ [ 50 , 51 ]. Increasing evidence also indicates that a variety of risk factors such as aging [ 71 ], malnutrition [ 72 ], obesity [ 73 , 74 , 75 ], and diabetes [ 27 , 76 ] can further superimpose on cadmium renal toxicity and aggravate cadmium-induced renal dysfunction.…”

Section: Cadmium-induced Animal Models Of Kidney Injurymentioning

confidence: 99%

Cadmium-Induced Kidney Injury: Oxidative Damage as a Unifying Mechanism

Allen

2021

Biomolecules

130

View full text Add to dashboard Cite

Cadmium is a nonessential metal that has heavily polluted the environment due to human activities. It can be absorbed into the human body via the gastrointestinal tract, respiratory tract, and the skin, and can cause chronic damage to the kidneys. The main site where cadmium accumulates and causes damage within the nephrons is the proximal tubule. This accumulation can induce dysfunction of the mitochondrial electron transport chain, leading to electron leakage and production of reactive oxygen species (ROS). Cadmium may also impair the function of NADPH oxidase, resulting in another source of ROS. These ROS together can cause oxidative damage to DNA, proteins, and lipids, triggering epithelial cell death and a decline in kidney function. In this article, we also reviewed evidence that the antioxidant power of plant extracts, herbal medicines, and pharmacological agents could ameliorate cadmium-induced kidney injury. Finally, a model of cadmium-induced kidney injury, centering on the notion that oxidative damage is a unifying mechanism of cadmium renal toxicity, is also presented. Given that cadmium exposure is inevitable, further studies using animal models are warranted for a detailed understanding of the mechanism underlying cadmium induced ROS production, and for the identification of more therapeutic targets.

show abstract

Section: Cadmium-induced Animal Models Of Kidney Injurymentioning

confidence: 99%

Cadmium-Induced Kidney Injury: Oxidative Damage as a Unifying Mechanism

Allen

2021

Biomolecules

130

View full text Add to dashboard Cite

show abstract

“…These results demonstrate the need for limiting Cd exposure to protect male fertility and reproductive health. Additionally, studies have demonstrated that Pb and Cd, either separately or together, have a detrimental effect on the process of testicular steroidogenesis [63,69,70]. Male reproductive health has been observed to decline as a result of exposure to Cd in numerous studies.…”

Section: Discussionmentioning

confidence: 99%

Impact of Cadmium and Lead Exposure on Camel Testicular Function: Environmental Contamination and Reproductive Health

Ullah

Ennab

Wei

et al. 2023

Animals

View full text Add to dashboard Cite

The free grazing habits of camels from various sources may cause heavy metals to bioaccumulate in their tissues and organs, possibly resulting in higher amounts of these toxic substances in their bodies over time. The aim of this study was to assess the exposure impact of lead (Pb) and cadmium (Cd) on bull camels of the Lassi breed, aged 7 to 8 years, at a site near the industrial area and another two non-industrial sites, to analyze the presence of heavy metals. Samples from three sites were collected from thirty camels (n = 10/each), soil and water (n = 30), and five different plants (n = 15/each) for analysis. Testes were collected for atomic absorption spectrometry (AAS), and hematoxylin-eosin (HE) staining. Serum samples were obtained to measure testosterone levels by radioimmunoassay (RIA). Samples were obtained from plants, soil, water, blood, serum and urine for AAS. According to the results, the testes’ weight, length, width, and volume significantly decreased at the industrial site compared with the other two sites as a result of exposure to Cd and Pb. Additionally, blood testosterone concentrations were considerably lower at the industrial site, indicating a detrimental impact on testicular steroidogenesis. The histological investigation of the industrial site indicated structural disturbances, including seminiferous tubule degeneration and shedding, cellular debris in seminiferous tubules, lining epithelium depletion, and vacuolation. Elevated amounts of Cd and Pb were found at the industrial site when analyzed using water, soil, plants, testes, serum, and urine. These findings demonstrate the adverse effects of Pb and Cd exposure on camel testicular function, including decreased weight and altered steroidogenesis. These findings are essential for understanding the impact of exposure to Pb and Cd on camel reproductive function and for developing successful prevention and management plans for these exposures in this species.

show abstract

“…0118U004201» Вступ. Кадмій (Cd) -токсичний метал, який широко присутній в багатьох матрицях навколишнього середовища і викликає серйозні несприятливі ефекти в різних органах і тканинах [1]. Прогнози показують, що забруднення навколишнього середовища Cd і, отже, вплив на населення в цілому буде збільшуватися.…”

Section: вплив кадмію на здоров'я дітей в пренатальний та постнатальний періоди розвиткуunclassified

Effect of Cadmium on Children's Health in Prenatal and Postnatal Periods of Development

Ostrovska¹,

Myasoid²,

Kovtunenko³

et al. 2021

Ukr. ž. med. bìol. sportu

View full text Add to dashboard Cite

The purpose of the study was to analyze on the basis of foreign literature the effects of the toxic action of cadmium on the process of embryonic and postnatal development of the child, which remain insufficiently studied. The consequences of cadmium effect on children remain insufficiently studied, although cadmium is a documented developmental toxicant. The studies show that the placenta is an important target tissue for cadmium toxic effects during pregnancy. The result of the accumulation of cadmium in the placenta is as follows: a decrease in the utero-placental circulation, changes in the integrity of cells of trophoblast and cell migration, a decrease in the synthesis and metabolism of placental hormones, disorder of the placental epigenetic regulation of cell growth, as well as immune and inflammatory signal transmission. The high level of cadmium in the placenta and umbilical cord blood can be a risk factor for deterioration of infants’ state and impact on the development of a child in the future. So far, only some aspects of the toxicokinetics of the placental cadmium and its adverse effect on intrauterine growth and development are known. The level of cadmium in the mother's serum during pregnancy is associated with the risk of premature birth. There are increasing evidence on connection between the effect of cadmium and unfavorable consequences of childbirth, as well as disorders of anthropometric indicators that differ in children of different gender. In the fetus of the female gender body weight at birth tends to decrease, the chest circumference had a tendency to decrease and these indicators corresponded to an increase in the level of cadmium in the mother’s blood. Cadmium acts as an immunotoxic agent from the very early age, even very low levels of cadmium exposure during pregnancy can lead to long-term detrimental consequences for the immune system of offspring and these effects, as well as others depend on the gender. Models to study the effect of cadmium at an early age on the development of diseases in more mature age are developed. The models in mice show that the effect of cadmium on the body leads to an increase in heart mass at birth and programs hypertension development in females in adulthood. Poisoning, which occurs at an early age (in utero and in early childhood), may have a strong influence on the risk of obesity and metabolic syndrome throughout life. The chronic prenatal effect of cadmium is associated with the late development of IQ in children, while prenatal influence of passive smoking has an increased risk of delaying cognitive development of infants aged 6 months. Early mortality from various diseases, including cancer, cardiovascular, respiratory, renal and neurological problems, correlated with intrauterine or early post-natal impact of metal. Conclusion. Cadmium is classified as a potential neurotoxicant, it reaches the brain in the early stages of the development of the fetus and is associated with behavioral and cognitive dysfunction, including bad learning memory in children of early and late childhood. The adverse consequences of the prenatal effect of cadmium for the development of the fetus and subsequent health of children have discovered a number of non-solved problems, the gender should be considered as a risk factor, since cadmium causes specific results that are veiled in mixed on gender investigations

show abstract

Effects of cadmium and high-fat diet on essential metal concentration in the mouse testis

Abstract: Graphical abstract

Cited by 7 publications

References 27 publications

Cadmium-Induced Kidney Injury: Oxidative Damage as a Unifying Mechanism

Cadmium-Induced Kidney Injury: Oxidative Damage as a Unifying Mechanism

Impact of Cadmium and Lead Exposure on Camel Testicular Function: Environmental Contamination and Reproductive Health

Effect of Cadmium on Children's Health in Prenatal and Postnatal Periods of Development

Contact Info

Product

Resources

About