Effects of cadmium on the female reproductive axis of a Neotropical fish

Vicentini, Maiara; Fernandes, Letícia da Silva Pereira; Marques, Antônio Ernesto Meister Luz; Osório, Flávio Henrique Tincani; Baika, Loana Mara; Risso, Wagner Ezequiel; Martinez, Cláudia Bueno dos Reis; Grassi, Marco Tadeu; Fávaro, Luiz Fernando; Prodocimo, Maritana Mela; Cestari, Marta Margarete; Assis, Helena Cristina Silva de

doi:10.1016/j.chemosphere.2021.131639

Cited by 18 publications

(11 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Based on this finding, they recommended the use of this approach for biomonitoring the contamination of aquatic environments, such as that found in the lower Amazon River. It is important to note that the liver is also an organ that contributes to reproductive activity in female fish, mainly from the production of vitellogenin, which is essential for the normal development of embryos (Wolf & Wheeler, 2018, Vicentini et al, 2022. Thus, studies conducted in natural environments can provide a more realistic picture of the health status of fish exposed to metals present in aquatic environments.…”

Section: Bioaccumulation Of Metals In Different Tissues Of C Asellusmentioning

confidence: 99%

“…All these factors contribute to the transport of waste contaminated with mixtures of toxicants, including metals, into the waters of the Amazon River. Vicentini et al (2022) highlighted that some metals, especially Cd, are considered endocrine disruptors in different fish species, which can affect their reproductive parameters. Therefore, assessment of the damage caused by inorganic contaminants in female fish is essential since these toxicants can be transferred to offspring or even affect the early stage of embryos (Bila & Dezotti, 2007, Vicentini et al, 2022.…”

Section: Bioaccumulation Of Metals In Different Tissues Of C Asellusmentioning

confidence: 99%

“…Vicentini et al (2022) highlighted that some metals, especially Cd, are considered endocrine disruptors in different fish species, which can affect their reproductive parameters. Therefore, assessment of the damage caused by inorganic contaminants in female fish is essential since these toxicants can be transferred to offspring or even affect the early stage of embryos (Bila & Dezotti, 2007, Vicentini et al, 2022. Vicentini et al (2022) also reported that environmentally relevant concentrations of Cd (0.1 and 100 μg/L) could alter the reproductive aspects of the native fish species Rhamdia quelen.…”

Section: Bioaccumulation Of Metals In Different Tissues Of C Asellusmentioning

confidence: 99%

“…The comparison also revealed higher genotoxicity index for C. asellus. It should be noted that various metals can bind to plasma proteins in fish blood and induce nuclear changes in erythrocytes (Vicentini et al, 2022).…”

Section: Genotoxicity Biomarkersmentioning

confidence: 99%

See 3 more Smart Citations

Bioaccumulation of metals and genotoxic effects in females of Colomesus asellus collected in an Amazon River estuary, Amapá, Brazil

Viana¹,

Souza²,

Silva³

et al. 2023

Limnetica

View full text Add to dashboard Cite

Colomesus asellus (Amazonian Puffer) is endemic to the Amazon Basin. It uses channels and streams to reproduce, spawn and feed. In areas close to urban centers, these fish may be exposed to anthropogenic residues containing mixtures of metals that can be bioaccumulated, resulting in genetic alterations. Therefore, we aimed to determine the extent of nuclear alterations in erythrocytes of female C. asellus resulting from the bioaccumulation of metals in tissues and organs. Metal concentrations were analyzed by atomic absorption spectrophotometry. Tissue metal concentrations decreased in the following order: Fe > Zn > Cu > Mn > Hg > Pb > Ni > Cd > Cr. In fish tissues/organs, the concentration of metals followed, in decreasing order, liver > skin > gonads > musculature > bones. The most frequent nuclear alterations were nuclear invagination, nuclear budding and lobulated nucleus. Metal concentrations and resultant nuclear alterations observed can damage C. asellus, thus compromising the conservation of this species at the mouth of the Amazon River.

show abstract

Section: Bioaccumulation Of Metals In Different Tissues Of C Asellusmentioning

confidence: 99%

Section: Bioaccumulation Of Metals In Different Tissues Of C Asellusmentioning

confidence: 99%

Section: Bioaccumulation Of Metals In Different Tissues Of C Asellusmentioning

confidence: 99%

Section: Genotoxicity Biomarkersmentioning

confidence: 99%

See 2 more Smart Citations

Bioaccumulation of metals and genotoxic effects in females of Colomesus asellus collected in an Amazon River estuary, Amapá, Brazil

Viana¹,

Souza²,

Silva³

et al. 2023

Limnetica

View full text Add to dashboard Cite

show abstract

“…It may reach 2 mg/L in contaminated water [ 3 ]. Cd accumulates rapidly in the organs and tissues of rainbow trout Onchorhynshus mykiss [ 4 ] and tilapia Oreochromis niloticus [ 5 ] and may diminish growth; affect behavior, plasma ion balance, and respiration of O. mykiss [ 6 ], O. niloticus [ 7 ], and carp Cyprinus carpio [ 8 ]; suppress hormone activity of Prussian carp Carassius auratus gibelio [ 9 ] and Neotropical fish Rhamdia quelen [ 10 ]; inhibit reproduction of red tilapia Oreochromis sp [ 11 ] and neotropical fish Prochilodus magdalenae [ 12 ]; lower hematological, biochemical parameters; and disrupt enzyme function of O. niloticus [ 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

Sublethal Effects of Cadmium on the Osmoregulatory and Acid-Base Parameters of Tilapia (Oreochromis niloticus) at Various Times

Soegianto

Yulianto

Payus

et al. 2023

Journal of Toxicology

View full text Add to dashboard Cite

Background. Cadmium (Cd) can contaminate aquatic environments as a result of anthropogenic activity. Cd accumulates quickly in the tissues of fish and has the potential to affect their physiology, including osmoregulation and acid-base balance. Therefore, the purpose of this study was to examine the sublethal effects of Cd on the osmoregulation and acid-base balance of tilapia Oreochromis niloticus at different times. Methods. Fish were exposed to sublethal concentrations of Cd (1 and 2 mg/L) for 4 and 15 days. At the end of the experiment, fish were collected from each treatment to examine the levels of Cd and carbonic anhydrase (CA) in the gills, plasma osmolality, ions, blood pH, pCO2, pO2, and hematological parameters. Results. Cd concentrations in gills rose with increasing Cd concentrations in the medium and exposure time. Cd inhibited respiration by generating metabolic acidosis, decreasing gill CA, reducing pO2, plasma osmolality, Cl−, and K+, particularly at 2 mg/L for 4 days and 1 and 2 mg/L for 15 days. Red blood cell (RBC), hemoglobin (Hb), and hematocrit (Ht) levels decreased as Cd levels in water and exposure duration increased. Conclusion. Cd inhibits respiration, lowers RCB, Hb, and Ht levels and decreases ionic and osmotic regulation. All of these impairments can limit a fish’s ability to provide appropriate oxygen to its cells, hence diminishing its physical activity and productivity.

show abstract

Cadmium aggravates liver injury by activating ferroptosis and neutrophil extracellular traps formation in Nile tilapia (Oreochromis niloticus)

Wang,

Chen,

Wang

et al. 2024

Environmental Toxicology

View full text Add to dashboard Cite

Cadmium (Cd) is a pervasive environmental contaminant and a significant risk factor for liver injury. The present study was undertaken to evaluate the involvement of ferroptosis and neutrophil extracellular traps (NETs) in Cd‐induced liver injury in Nile tilapia (Oreochromis niloticus), and to explore its underlying mechanism. Cd‐induced liver injury was associated with increased total iron, malondialdehyde (MDA), and Acyl‐CoA synthetase long‐chain family member 4 (ACSL4), together with reduced levels of glutathione, glutathione peroxidase‐4a (Gpx4a), and solute carrier family 7 member 11 (SLC7A11), which are all hallmarks of ferroptosis. Moreover, liver hyperemia, neutrophil infiltration, increased inflammatory factors and myeloperoxidase, as well as elevated serum DNA content in Cd‐stimulated Nile tilapia suggested that a considerable number of neutrophils were recruited to the liver. Furtherly, in vitro experiments demonstrated that Cd induced the formation of NETs, and the possible mechanism was related to the generation of reactive oxygen species and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, along with the P38 and extracellular regulated protein kinase (ERK) signaling pathways. We concluded that ferroptosis and NETs are the critical mechanisms contributing to Cd‐induced liver injury in Nile tilapia. These findings will contribute to Cd toxicological studies in aquatic animals.

show abstract

Effects of cadmium on the female reproductive axis of a Neotropical fish

Cited by 18 publications

References 60 publications

Bioaccumulation of metals and genotoxic effects in females of Colomesus asellus collected in an Amazon River estuary, Amapá, Brazil

Bioaccumulation of metals and genotoxic effects in females of Colomesus asellus collected in an Amazon River estuary, Amapá, Brazil

Sublethal Effects of Cadmium on the Osmoregulatory and Acid-Base Parameters of Tilapia (Oreochromis niloticus) at Various Times

Cadmium aggravates liver injury by activating ferroptosis and neutrophil extracellular traps formation in Nile tilapia (Oreochromis niloticus)

Contact Info

Product

Resources

About