Effects of caffeic acid phenethyl ester and alpha‐tocopherol on reperfusion injury in rat brain

Irmak, M. Kemal; Fadıllıoğlu, Ersin; Söğüt, Sadık; Erdoğan, Hasan; Güleç, Mukaddes; Özer, Mustafa; Yagmurca, Murat; Gözükara, M. Engin

doi:10.1002/cbf.1024

Cited by 114 publications

(77 citation statements)

References 43 publications

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“…In the present study, levels of MDA, antioxidant enzymes (SOD and GSH-Px) and GSH of blood and some organs were found similar in the groups. It can be speculated that there was no correlation of antioxidant enzyme activities between tissues (Irmak et al 2003). Similarly, Okutan et al (2005) reported that there is no consensus in the level of antioxidant enzymes of many organs in diabetic rats.…”

Section: Discussionmentioning

confidence: 99%

Effects of Propolis on Selected Blood Indicators and Antioxidant Enzyme Activities in Broilers under Heat Stress

et al. 2009

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In this study, we investigated the antioxidant activity of ethanol extracts of propolis (EEP) and vitamin C on biochemical indicators and antioxidant enzyme activities of broilers exposed to heat stress (at 34 °C). The experimental groups were as follows: group I (positive control) and group II (control) were fed a basal diet, group III (vitamin C) was fed a basal diet supplemented with 250 mg vitamin C as ascorbic acid/kg, group IV (EEP-0.5) was fed a basal diet supplemented with 0.5 g EEP/kg, group V (EEP-1) was fed a basal diet supplemented with 1 g EEP/kg, group VI (EEP-3) was fed a basal diet supplemented with 3 g EEP/kg. Plasma superoxide dismutase levels of positive control, control, vitamin C, EEP-0.5, EEP-1 and EEP-3 groups were found as 0.34, 1.23, 0.50, 0.90, 0.30 and 0.41 μkat/ml, respectively (p < 0.01). Aspartate transaminase (except for EEP-0.5 and EEP-1 groups) and alkaline phosphatase in the control group were significantly higher than those of positive control, vitamin-C and EEP-3 groups. Malondialdehyde level in plasma, liver and muscle tissues of control group were found significantly (p < 0.05) higher than those of positive control and EEP-3 groups. Catalase activities of blood, liver, kidney and heart were the highest in the control group. Reduced glutathione activities of plasma and liver of all groups were not significantly different from each other, whereas those of muscle, kidney and heart were significantly higher in the control group. Significantly lower levels of glutathione peroxidase were found in blood, liver and kidney tissues of the control group (p < 0.05), whereas those of muscle and heart were similar in all groups. The results of the present study suggest that EEP and specially EEP at the supplemented dose of 3 mg/kg diet might be considered to prevent oxidative stress in the broilers exposed to heat stress.

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Section: Discussionmentioning

confidence: 99%

Effects of Propolis on Selected Blood Indicators and Antioxidant Enzyme Activities in Broilers under Heat Stress

et al. 2009

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“…It has been demonstrated to be a specific inhibitor of activation of nuclear transcript factor NF-B (2,3). Previous studies have shown that this compound could protect the spinal cord and brain from ischemia reperfusion injury (4,5) and prevent neurotoxic events caused by excessive inflammatory reaction in brain (6). Several lines of evidence also indicate that CAPE may modify the redox state in transformed fibroblast cells and in leukemic HL-60 cells (7)(8)(9).…”

Section: Caffeic Acid Phenethyl Ester (Cape)mentioning

confidence: 99%

Stimulatory Actions of Caffeic Acid Phenethyl Ester, a Known Inhibitor of NF-κB Activation, on Ca2+-activated K+ Current in Pituitary GH3 Cells

Lin

Yang

Huang

et al. 2004

Journal of Biological Chemistry

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Caffeic acid phenethyl ester (CAPE), a phenolic antioxidant derived from the propolis of honeybee hives, is known to be an inhibitor of activation of nuclear transcript factor NF-B. Its effects on ion currents have been investigated in pituitary GH 3 cells. This compound increased Ca 2؉ -activated K ؉ current (I K(Ca) ) in a concentration-dependent manner with an EC 50 value of 14 ؎ 2 M. However, the magnitude of CAPEinduced stimulation of I K(Ca) was attenuated in GH 3 cells preincubated with 2,2-azo-bis-(2-amidinopropane) hydrochloride (100 M) or t-butyl hydroperoxide (1 mM). CAPE (50 M) slightly suppressed voltage-dependent L-type Ca 2؉ current. In inside-out configuration, CAPE (20 M) applied to the intracellular face of the detached patch enhanced the activity of large conductance Ca 2؉ -activated K ؉ (BK Ca ) channels with no modification in single-channel conductance. After BK Ca channel activity was increased by CAPE (20 M), subsequent application of nordihydroguaiaretic acid (20 M) did not further increase the channel activity. CAPE-stimulated channel activity was dependent on membrane potential. CAPE could also increase Ca 2؉ sensitivity of BK Ca channels in these cells. Its increase in the open probability could primarily involve a decrease in the mean closed time. In current-clamp conditions, CAPE hyperpolarized the membrane potential and reduced the firing of action potentials. The stimulatory effects on these channels may partly contribute to the underlying mechanisms through which this compound influences the functional activities of neurons or neuroendocrine cells. Caution has to be used in attributing its response in the activation of NF-B.

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“…ROS involve free radicals that contain one or more unpaired electrons. ROS-induced oxidative stress has been implicated in variously pathological conditions: cancer, diabetes, ischemia/reperfusion, aging and neuropsychiatric disorders (Lohr, 1991;Sayre et al, 2001;Irmak et al, 2003;Jenner, 2003;Dalle-Donne et al, 2006). Accumulation of ROS induces oxidative damage, which involves cellular proteins, lipids, nucleic acids and DNA after an ischemic insult, which leads to neuronal death (Radi et al, 1993;Giulivi et al, 1995).…”

Section: Introductionmentioning

confidence: 99%

Neuroprotective effects ofAlpinia katsumadaiagainst experimental ischemic damage via control of oxidative stress

Park

Lee

et al. 2012

Pharmaceutical Biology

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Effects of caffeic acid phenethyl ester and alpha‐tocopherol on reperfusion injury in rat brain

Cited by 114 publications

References 43 publications

Effects of Propolis on Selected Blood Indicators and Antioxidant Enzyme Activities in Broilers under Heat Stress

Effects of Propolis on Selected Blood Indicators and Antioxidant Enzyme Activities in Broilers under Heat Stress

Stimulatory Actions of Caffeic Acid Phenethyl Ester, a Known Inhibitor of NF-κB Activation, on Ca2+-activated K+ Current in Pituitary GH3 Cells

Neuroprotective effects ofAlpinia katsumadaiagainst experimental ischemic damage via control of oxidative stress

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