Effects of caffeine and acetylcholine on glucose-stimulated insulin release from islet transplants in mice

Shi, Chun-Liang

doi:10.1016/s0963-6897(96)00181-9

Cited by 12 publications

(12 citation statements)

References 17 publications

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“…Consistent with this, theophylline and caffeine markedly potentiate glucose-induced insulin secretion (101,102). At high concentrations, caffeine inhibits glucose transport (103) but still stimulates insulin secretion (20,104,105). Stimulation of insulin secretion by caffeine and theophylline is tacitly assumed to be solely due to cAMP.…”

Section: Role Of Ry Receptors In Glucose-stimulated Insulin Secretionmentioning

confidence: 82%

The Ryanodine Receptor Calcium Channel of β-Cells

Islam

2002

Diabetes

112

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Section: Role Of Ry Receptors In Glucose-stimulated Insulin Secretionmentioning

confidence: 82%

The Ryanodine Receptor Calcium Channel of β-Cells

Islam

2002

Diabetes

112

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“…In 1970, it showed that in nondiabetic volunteers coffee consumption over a period of 14 days caused a reduction in plasma levels of fasting glucose. Shi (1997) evaluated the effect of caffeine found in animal models serving as stimulating insulin secretion.…”

Section: Resultsmentioning

confidence: 99%

“…There are also data from animal studies indicating that caffeine (Shi, 1997), but most of chlorogenic acid and derivatives (Arion et al, 1997;Clifford, 2000;Ong et al, 2012;Hunyadi et al, 2012) have hypoglycemic effect by different mechanisms. Likewise, magnesium administration has been associated with reduction of hyperglycemia induced by alloxan (Abayomi et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Anti-diabetic effect of Coffea arabica, in alloxan-induced diabetic rats

Florián

Bardales-Valdivia

Caruajulca-Guevara

et al. 2013

Emir. J. Food Agric

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The coffee bean could provide benefits in cardiovascular and metabolic diseases. The anti-diabetic effect of extracts of Coffea arabica was evaluated in diabetic rats. The aqueous extract of coffee green grain (63 and 93mg/kg) was administered once daily for fifteen days to alloxan-induced diabetic rats. The effect of aqueous extract on fasting blood glucose levels was measured. After 8 and 15 day of treatment, aqueous extract of coffee green grain administration showed significantly lower blood glucose levels compared to the diabetic control group. The findings from this study suggest that extract of coffee can alleviate hyperglycemia of diabetes.

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“…Normal lean mice (BALB/c, Bomholtgård, Ry, Denmark) weighing 20-25 g were starved overnight, and islets were isolated by collagenase digestion and the dextran purification method (25). Islets were then cultured overnight in RPMI 1640 medium containing 10% FBS, 11.2 mM glucose, 60 i.u./ml penicillin, and 60 µg/ml gentamicin, in a water-saturated atmosphere of air and 5% CO 2…”

Section: Islet Preparationmentioning

confidence: 99%

“…The average rate of insulin secretion (ng/min/50 islets) was calculated by integrating individual perifusion profile. Insulin was measured by radioimmunoassay, using crystalline mouse insulin as standard (25).…”

Section: Insulin Release From Isletsmentioning

confidence: 99%

Ryanodine receptors of pancreatic β‐cells mediate a distinct context‐dependent signal for insulin secretion

Bruton¹,

Lemmens²,

Shi³

et al. 2002

FASEB j.

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The ryanodine (RY) receptors in beta-cells amplify signals by Ca2+-induced Ca2+ release (CICR). The role of CICR in insulin secretion remains unclear in spite of the fact that caffeine is known to stimulate secretion. This effect of caffeine is attributed solely to the inhibition of cAMP-phosphodiesterases (cAMP-PDEs). We demonstrate that stimulation of insulin secretion by caffeine is due to a sensitization of the RY receptors. The dose-response relationship of caffeine-induced inhibition of cAMP-PDEs was not correlated with the stimulation of insulin secretion. Sensitization of the RY receptors stimulated insulin secretion in a context-dependent manner, that is, only in the presence of a high concentration of glucose. This effect of caffeine depended on an increase in [Ca2+]i. Confocal images of beta-cells demonstrated an increase in [Ca2+]i induced by caffeine but not by forskolin. 9-Methyl-7-bromoeudistomin D (MBED), which sensitizes RY receptors, did not inhibit cAMP-PDEs, but it stimulated secretion in a glucose-dependent manner. The stimulation of secretion by caffeine and MBED involved both the first and the second phases of secretion. We conclude that the RY receptors of beta-cells mediate a distinct glucose-dependent signal for insulin secretion and may be a target for developing drugs that will stimulate insulin secretion only in a glucose-dependent manner.

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Effects of caffeine and acetylcholine on glucose-stimulated insulin release from islet transplants in mice

Cited by 12 publications

References 17 publications

The Ryanodine Receptor Calcium Channel of β-Cells

The Ryanodine Receptor Calcium Channel of β-Cells

Anti-diabetic effect of Coffea arabica, in alloxan-induced diabetic rats

Ryanodine receptors of pancreatic β‐cells mediate a distinct context‐dependent signal for insulin secretion

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