Effects of Caffeine on Colon: A Potential Clinical Use of Coffee in Surgical Patients

Mattioli, Anna Vittoria; Nasi, Milena; Farinetti, Alberto; Gelmini, Roberta

doi:10.1159/000499198

Cited by 1 publication

(1 citation statement)

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“…The factors may be caffeine and other substances in coffee, mainly phenolic antioxidants of chlorogenic acid [36]. Caffeine acts positively on inflammation, activating ryanodinesensitive Ca 2+ channels by releasing Ca 2+ from the sarcoplasmic reticulum and inhibiting cyclic guanosine monophosphate degradation, thereby promoting nitric oxide synthesis in the endothelium and enhancing caffeine-induced endothelium-dependent vasodilation [37][38][39]. Caffeine promotes postoperative recovery of gastrointestinal function through vasodilation [32,40].…”

Section: Discussionmentioning

confidence: 99%

Effect of Postoperative Coffee Consumption on Postoperative Ileus after Abdominal Surgery: An Updated Systematic Review and Meta-Analysis

et al. 2021

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Background: Previous systematic reviews have not clarified the effect of postoperative coffee consumption on the incidence of postoperative ileus (POI) and the length of hospital stay (LOS). We aimed to assess its effect on these postoperative outcomes. Methods: Studies evaluating postoperative coffee consumption were searched using electronic databases until September 2021 to perform random-effect meta-analysis. The quality of evidence was assessed using the Cochrane risk-of-bias tool. Caffeinated and decaffeinated coffee were also compared. Results: Thirteen trials (1246 patients) and nine ongoing trials were included. Of the 13 trials, 6 were on colorectal surgery, 5 on caesarean section, and 2 on gynecological surgery. Coffee reduced the time to first defecation (mean difference (MD) −10.1 min; 95% confidence interval (CI) = −14.5 to −5.6), POI (risk ratio 0.42; 95% CI = 0.26 to 0.69); and LOS (MD −1.5; 95% CI = −2.7 to −0.3). This trend was similar in colorectal and gynecological surgeries. Coffee had no adverse effects. There was no difference in POI or LOS between caffeinated and decaffeinated coffee (p > 0.05). The certainty of evidence was low to moderate. Conclusion: This review showed that postoperative coffee consumption, regardless of caffeine content, likely reduces POI and LOS after colorectal and gynecological surgery.

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