Effects of caffeine on glucose tolerance: A placebo-controlled study

Pizziol, Alessandra; Tikhonoff, Valérie; Paleari, C. D.; Russo, Elisa; Mazza, Alberto; Ginocchio, Giuliana; Onesto, Caterina; Pavan, L.; Casíglia, Edoardo; Pessina, A. C.

doi:10.1038/sj.ejcn.1600657

Cited by 62 publications

(37 citation statements)

References 32 publications

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“…It is probably the most widely consumed psychoactive substance, due to its presence in coffee, tea, and medicinal products [2]. The effect of caffeine on glucose tolerance is still controversial, as previous studies have indicated that blood glucose concentrations are found to be, variously, higher, lower, or unchanged following caffeine administration [3,4]. Diabetes mellitus is a common chronic human disease.…”

Section: Introductionmentioning

confidence: 99%

A histological and immunohistochemical study of beta cells in streptozotocin diabetic rats treated with caffeine

Abunasef

Amin

Abdel-Hamid

2014

Folia Histochem Cytobiol.

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Abstract:In this study, the histological, immunohistochemical, morphometric, and biochemical changes to pancreatic beta-cells in STZ-induced diabetes were evaluated in rats treated with different doses of caffeine. Fifty adult male Wistar albino rats were divided into five groups: the nondiabetic control group, the diabetic untreated group, and three diabetic groups treated with different doses of caffeine (10, 50, and 100 mg/kg/day). Blood glucose and serum insulin levels were measured. The pancreata were collected and processed into paraffin sections. They were stained using hematoxylin and eosin (H&E) and Masson trichrome stains. The insulin expression in beta-cells was assessed using immunohistochemistry. Morphometrically, the percentage area of anti-insulin antibody reaction, the percentage of beta-cells per total islet cell number, and the average area of the islets were determined. STZ-induced degenerative changes in beta-cells led to decreases in the number of functioning beta-cells and insulin immunoreactivity and to increases in the number of collagen fibers in the islets. In STZ-treated rats, caffeine significantly decreased blood glucose concentration while increasing blood insulin levels at the highest applied dose. It also induced a significant increase in the number of immunoreactive beta-cells. In conclusion, caffeine may have a protective role in the biochemical and microscopic changes in pancreatic beta-cells in diabetes induced in rats through STZ administration.

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Section: Introductionmentioning

confidence: 99%

A histological and immunohistochemical study of beta cells in streptozotocin diabetic rats treated with caffeine

Abunasef

Amin

Abdel-Hamid

2014

Folia Histochem Cytobiol.

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“…Roasting of coffee can transform some of the chlorogenic acid into quinides, which have been shown to enhance insulin action in rats [17]. Caffeine acutely lowered insulin sensitivity [18,19,20,21,22] and increased glucose concentrations [23,24,25,26,27] in short-term metabolic studies in humans. However, these effects may not persist during chronic coffee consumption [19], and beneficial effects of caffeine on insulin sensitivity [28] and glucose-induced insulin secretion [29] have also been suggested.…”

Section: Introductionmentioning

confidence: 99%

Coffee consumption and incidence of impaired fasting glucose, impaired glucose tolerance, and type 2 diabetes: the Hoorn Study

Dam¹,

et al. 2004

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Aims/hypothesis. Coffee contains several substances that may affect glucose metabolism. The aim of this study was to evaluate the relationship between habitual coffee consumption and the incidence of IFG, IGT and type 2 diabetes. Methods. We used cross-sectional and prospective data from the population-based Hoorn Study, which included Dutch men and women aged 50-74 years. An OGTT was performed at baseline and after a mean follow-up period of 6.4 years. Associations were adjusted for potential confounders including BMI, cigarette smoking, physical activity, alcohol consumption and dietary factors. Results. At baseline, a 5 cup per day higher coffee consumption was significantly associated with lower fasting insulin concentrations (−5.6%, 95% CI −9.3 to −1.6%) and 2-h glucose concentrations (−8.8%, 95% CI −11.8 to −5.6%), but was not associated with lower fasting glucose concentrations (−0.8%, 95% CI −2.1 to 0.6%). In the prospective analyses, the odds ratio (OR) for IGT was 0.59 (95% CI 0.36-0.97) for 3-4 cups per day, 0.46 (95% CI 0.26-0.81) for 5-6 cups per day, and 0.37 (95% CI 0.16-0.84) for 7 or more cups per day, as compared with the corresponding values for the consumption of 2 or fewer cups of coffee per day (p=0.001 for trend). Higher coffee consumption also tended to be associated with a lower incidence of type 2 diabetes (OR 0.69, CI 0.31-1.51 for ≥7 vs ≤2 cups per day, p=0.09 for trend), but was not associated with the incidence of IFG (OR 1.35, CI 0.80-2.27 for ≥7 vs ≤2 cups per day, p=0.49 for trend). Conclusions/interpretation. Our findings indicate that habitual coffee consumption can reduce the risk of IGT, and affects post-load rather than fasting glucose metabolism.

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“…More recent investigations have also produced conflicting results. Pizziol et al (18) reported an increase in glucose concentration with no effect on insulin levels after the ingestion of caffeinated coffee during the administration of an oral glucose tolerance test. This contrasts a report by Battram et al (19), who observed a significant increase in insulin and no difference in blood glucose levels after the ingestion of an oral glucose load in the caffeine trial compared with the placebo trial.…”

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confidence: 99%

“…Once again, inadequate study design could be a reason for these conflicting results. Pizziol et al (18) used coffee as their administration vehicle, the majority of subjects were women and were not monitored for their menstrual status, and the caffeine content of coffee was not indexed for body weight.…”

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confidence: 99%

Caffeine Ingestion Decreases Glucose Disposal During a Hyperinsulinemic-Euglycemic Clamp in Sedentary Humans

et al. 2001

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The purpose of this investigation was to examine the effect of caffeine (an adenosine receptor antagonist) on whole-body insulin-mediated glucose disposal in resting humans. We hypothesized that glucose disposal would be lower after the administration of caffeine compared with placebo. Healthy, lean, sedentary (n ‫؍‬ 9) men underwent two trial sessions, one after caffeine administration (5 mg/kg body wt) and one after placebo administration (dextrose) in a double-blind randomized design. Glucose disposal was assessed using a hyperinsulinemic-euglycemic clamp. Before the clamp, there were no differences in circulating levels of methylxanthines, catecholamines, or glucose. Euglycemia was maintained throughout the clamp with no difference in plasma glucose concentrations between trials. The insulin concentrations were also similar in the caffeine and placebo trials. After caffeine administration, glucose disposal was 6.38 ؎ 0.76 mg/kg body wt compared with 8.42 ؎ 0.63 mg/kg body wt after the placebo trial. This represents a significant (P < 0.05) decrease (24%) in glucose disposal after caffeine ingestion. In addition, carbohydrate storage was 35% lower (P < 0.05) in the caffeine trial than in the placebo trial. Furthermore, even when the difference in glucose disposal was normalized between the trials, there was a 23% difference in the amount of carbohydrate stored after caffeine administration compared with placebo administration. Caffeine ingestion also resulted in higher plasma epinephrine levels than placebo ingestion (P < 0.05). These data support our hypothesis that caffeine ingestion decreases glucose disposal and suggests that adenosine plays a role in regulating glucose disposal in resting humans.

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Effects of caffeine on glucose tolerance: A placebo-controlled study

Cited by 62 publications

References 32 publications

A histological and immunohistochemical study of beta cells in streptozotocin diabetic rats treated with caffeine

A histological and immunohistochemical study of beta cells in streptozotocin diabetic rats treated with caffeine

Coffee consumption and incidence of impaired fasting glucose, impaired glucose tolerance, and type 2 diabetes: the Hoorn Study

Caffeine Ingestion Decreases Glucose Disposal During a Hyperinsulinemic-Euglycemic Clamp in Sedentary Humans

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