Effects of Caffeine on Plasma Renin Activity, Catecholamines and Blood Pressure

Robertson, David; Lich, J. C. Fr; Carr, R. Keith; Watson, J. Throck; Hollifield, John W.; Shand, David G.; Oates, John A.

doi:10.1097/00132586-197812000-00020

Cited by 85 publications

(117 citation statements)

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“…However, other studies have shown that concentrations of caffeine as low as 1 jig ml-' stimulate prostaglandin output from rat blood vessels (Naderali & Poyser, unpublished observations). The average cup of coffee contains about 100 mg caffeine and, after drinking 300 ml of a beverage containing 250 mg caffeine, the plasma concentration obtained 1 h later is between 4.2 and 26 jig ml ' (Robertson et al, 1978). Therefore, there is some evidence that caffeine can release prostaglandin from tissues in concentrations that are obtained after drinking 1 or 2 cups of coffee.…”

Section: Discussionmentioning

confidence: 99%

The effect of caffeine on prostaglandin output from the guinea‐pig uterus

Naderali

Poyser

1994

British J Pharmacology

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1 Caffeine increased the outputs of prostaglandin F2,. (PGF2.a), PGE2 and 6-keto-PGFI, from the guinea-pig uterus on days 7 and 15 of the oestrous cycle. The effect on PGE2 output depended on the age of the animals and was absent in younger guinea-pigs (<4 months). Theophylline also stimulated the outputs of PGF2,. and 6-keto-PGFI6, but not the output of PGE2, from the day 7 guinea-pig uterus. 2 The stimulatory effects of caffeine on the outputs of PGFu, PGE2 and 6-keto-PGFI. from the guinea-pig uterus were not prevented by lack of extracellular calcium, ryanodine or ruthenium red (both inhibitors of calcium release via the ryanodine receptor), although the increase in PGFu. output tended to be slower when extracellular calcium was absent. Also, ryanodine flattened and broadened the peak of increased PGFu. release.3 The calmodulin antagonists, W-7 and trifluoperazine, had no inhibitory effect on the caffeinestimulated increases in uterine prostaglandin output. In fact, W-7 (but not trifluoperazine) greatly potentiated the action of caffeine on uterine PGF2, output, but had little or no potentiating effect on the action of caffeine on uterine PGE2 and 6-keto-PGFIc outputs.4 TMB-8, an intracellular calcium antagonist, inhibited the increase in PGF2,, output produced by caffeine without preventing the increases in outputs of PGE2 and 6-keto-PGF1I. 5 These studies suggest that caffeine stimulates uterine PGF2, synthesis and release by a mechanism dependent upon intracellular calcium, but this mechanism is not mediated by activation of any of the three well-characterized ryanodine receptors or by calmodulin. Furthermore, the increases in the synthesis and release of PGE2 and 6-keto-PGFI. in the guinea-pig uterus induced by caffeine appear to involve mechanism(s) different from that which stimulates PGF2. production.

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Section: Discussionmentioning

confidence: 99%

The effect of caffeine on prostaglandin output from the guinea‐pig uterus

Naderali

Poyser

1994

British J Pharmacology

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“…Furthermore, it has been shown that caffeine ingestion is a potent stimulus of adrenomedullary catecholamine release. 25 Therefore, to prevent false-positive tests, it has been suggested that cigarettes and coffee should be avoided prior to blood sampling. 7 Because some groups observed contaminated chromatograms which were attributed to unidentified interfering substances, it has also been stated that tests should generally be performed on fasted subjects.…”

Section: Influence Of Dietary Constituentsmentioning

confidence: 99%

Influence of various confounding variables and storage conditions on metanephrine and normetanephrine levels in plasma

Deutschbein

Unger

Jaeger

et al. 2010

Clinical Endocrinology

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“…34 None the less, it has been shown that sympathetic activity occurs as a result of water drinking and plasma noradrenalin levels increase after water drinking by a magnitude at least as great as that elicited by smoking two unfiltered cigarettes (97 pg/mL increase) 35 or ingesting 250 mg of caffeine (102 pg/mL increase). 36 This may contribute to the increase in IOP seen in glaucoma patients if such patients have a component of autonomic dysfunction, as has been proposed by some. Abnormal autoregulatory mechanisms in choroidal vasculature may result in alterations in choroidal volume in eyes with glaucoma similar to mechanisms proposed by Quigley 37 as a mechanism for aqueous misdirection.…”

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confidence: 89%

The water‐drinking test: the elegance of simplicity

Danesh‐Meyer

2008

Clinical Exper Ophthalmology

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Effects of Caffeine on Plasma Renin Activity, Catecholamines and Blood Pressure

Cited by 85 publications

References 0 publications

The effect of caffeine on prostaglandin output from the guinea‐pig uterus

The effect of caffeine on prostaglandin output from the guinea‐pig uterus

Influence of various confounding variables and storage conditions on metanephrine and normetanephrine levels in plasma

The water‐drinking test: the elegance of simplicity

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